Natalie Leys

Research output

Research output per year 2005 2009 2010 2012 2013 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024

• 108 Article
• 10 Chapter
• 10 Professional Bachelor's thesis
• 8 ER - External report
• 25 More
  • 7 Third partyreport
  • 4 Literature review
  • 4 Master's thesis
  • 2 In-proceedings paper
  • 2 Special issue
  • 2 Review article
  • 2 Doctoral thesis
  • 1 Book of abstracts
  • 1 Academic Bachelor's thesis

Research output per year

Research output per year

Search results

• 2024

  Benchmarking short-, long- and hybrid-read assemblers for metagenome sequencing of complex microbial communities

  Goussarov, G., Ahmed, M. M., Cleenwerck, I., Claesen, J., Leys, N., Vandamme, P. & Van Houdt, R., 2024, In: Microbiology. 170, 6, 13 p., 001469.

  Research output › peer-review

  Open Access

• Physiological and genomic analysis of Limnospira sp. AlgLouSa11 isolated from Tamanrasset, Algeria

  Lounici, S., Boutekrabt, L., Doumandji, A., Salhi, S., Van Houdt, R. & Leys, N., Jul 2024, In: Algal Research. 81, 9 p., 103569.

  Research output › peer-review

• Radiotolerance of N-cycle bacteria and their transcriptomic response to low-dose space-analogue ionizing irradiation

  Verbeelen, T., Fernandez, C. A., Nguyen, T. H., Gupta, S., Leroy, B., Wattiez, R., Vlaeminck, S. E., Leys, N., Ganigué, R. & Mastroleo, F., May 2024, In: iScience. 27, 5, 19 p., 109596.

  Research output › peer-review

  Open Access

• Whole transcriptome analysis highlights nutrient limitation of nitrogen cycle bacteria in simulated microgravity

  Verbeelen, T., Alvarez Hernandez, C., Nguyen, T. H., Gupta, S., Aarts, R., Tabury, K., Leroy, B., Wattiez, R., Vlaeminck, S. E., Leys, N., Ganigué, R. & Mastroleo, F., Dec 2024, In: npj Microgravity. 10, 1, 19 p., 3.

  Research output › peer-review

  Open Access
• 2023

  Assessment of batch culture conditions for cyanobacterial propagation for a bioreactor in space

  Fahrion, J., Dussap, C.-G. & Leys, N., Apr 2023, In: Frontiers in Astronomy and Space Sciences. 10, 15 p., 1178332.

  Research output › peer-review

  Open Access

• Enhancing European capabilities for application of multi-omics studies in biology and biomedicine space research

  Manzano, A., Weging, S., Bezdan, D., Borg, J., Cahill, T., Carnero-Diaz, E., Cope, H., Deane, C. S., Etheridge, T., Giacomello, S., Hardiman, G., Leys, N., Madrigal, P., Mastroleo, F., Medina, F. J., Mieczkowski, J., Fernandez-Rojo, M. A., Siew, K., Szewczyk, N. J. & Walsh, S. B. & 2 others, Silveira, W. A. D. & Herranz, R., 15 Sep 2023, In: iScience. 26, 9, 107289.

  Research output › peer-review

  Open Access

• Future space experiment platforms for astrobiology and astrochemistry research

  Elsaesser, A., Burr, D. J., Mabey, P., Urso, R. G., Billi, D., Cockell, C., Cottin, H., Kish, A., Leys, N., van Loon, J. J. W. A., Mateo-Marti, E., Moissl-Eichinger, C., Onofri, S., Quinn, R. C., Rabbow, E., Rettberg, P., de la Torre Noetzel, R., Slenzka, K., Ricco, A. J. & de Vera, J. P. & 1 others, Westall, F., Dec 2023, In: npj Microgravity. 9, 1, 9 p., 43.

  Research output › peer-review

  Open Access
  1 Scopus citations

• Human intestinal organoids and microphysiological systems for modeling radiotoxicity and assessing radioprotective agents

  Bouges, E., Segers, C., Leys, N., Lebeer, S., Zhang, J. & Mastroleo, F., 15 Dec 2023, In: Cancers. 15, 24, 20 p., 5859.

  Research output › peer-review

  Open Access

• Limnospira indica PCC8005 and lacticaseibacillus rhamnosus GG mixed dietary combination reduces pelvic irradiation-induced symptoms in mice

  Gholam, S.-R., Segers, C., Ahmed, M. M., Coolkens, A., Baatout, S., Leys, N. & Mastroleo, F., 11 May 2023, In: Applied Microbiology. 3, 2, p. 448-464 17 p.

  Research output › peer-review

  Open Access

• Limnospira indica PCC 8005 supplementation prevents pelvic irradiation-induced dysbiosis but not acute inflammation in mice

  Segers, C., Ahmed, M. M., Coolkens, A., Wouters, S., Baatout, S., Leys, N., Lebeer, S., Verslegers, M. & Mastroleo, F., Mar 2023, In: Antioxidants. 12, 3, 18 p., 572.

  Research output › peer-review

  Open Access

• Photosynthetic microorganisms, an overview of their biostimulant effects on plants and perspectives for space agriculture

  Renaud, C., Leys, N. & Wattiez, R., Aug 2023, In: Journal of Plant Interactions. 18, 1, 17 p., 2242697.

  Research output › peer-review

  Open Access

• Plant and microbial science and technology as cornerstones to Bioregenerative Life Support Systems in space

  De Micco, V., Amitrano, C., Mastroleo, F., Aronne, G., Battistelli, A., Carnero-Diaz, E., De Pascale, S., Detrell, G., Dussap, C. G., Ganigué, R., Jakobsen, Ø. M., Poulet, L., Van Houdt, R., Verseux, C., Vlaeminck, S. E., Willaert, R. & Leys, N., Dec 2023, In: npj Microgravity. 9, 1, 12 p., 69.

  Research output › peer-review

  Open Access

• PrsQ2, a small periplasmic protein involved in increased uranium resistance in the bacterium Cupriavidus metallidurans

  Mijnendonckx, K., Rogiers, T., Giménez, F. J., Merroun, M., Williamson, A., Ali, M. M., Charlier, D., Leys, N., Boon, N. & Van Houdt, R., 15 Feb 2023, In: Journal of Hazardous Materials. 444, p. 1-9 9 p., 130410.

  Research output › peer-review

  Open Access

• RNA extraction protocol from low-biomass bacterial Nitrosomonas europaea and Nitrobacter winogradskyi cultures for whole transcriptome studies

  Verbeelen, T., Houdt, R. V., Leys, N., Ganigué, R. & Mastroleo, F., 15 Sep 2023, In: STAR Protocols. 4, 3, 9 p., 102358.

  Research output › peer-review

  Open Access

• The waterbodies of the halo-volcanic Dallol complex: earth analogs to guide us, where to look for life in the universe

  Moors, H., De Craen, M., Smolders, C., Provoost, A. & Leys, N., 14 Jul 2023, In: Frontiers in Microbiology. 14, 15 p., 1134760.

  Research output › peer-review

  Open Access
• 2022

  Cupriavidus metallidurans NA4 actively forms polyhydroxybutyrate-associated uranium-phosphate precipitates

  Rogiers, T., Merroun, M. L., Williamson, A., Leys, N., Van Houdt, R., Boon, N. & Mijnendonckx, K., 5 Jan 2022, In: Journal of Hazardous Materials. 421, p. 1-10 10 p., 126737.

  Research output › peer-review

  Open Access

• Limnospira indica PCC 8005 or Lacticaseibacillus rhamnosus GG Dietary Supplementation Modulate the Gut Microbiome in Mice

  Segers, C., Ahmed, M., Coolkens, A., Baatout, S., Leys, N., Lebeer, S., Verslegers, M. & Mastroleo, F., 31 Aug 2022, In: Applied Microbiology. 2, 3, p. 636-650 15 p., 1030049.

  Research output › peer-review

  Open Access

  File
  44 Downloads (Pure)

• Metaproteomics, heterotrophic growth, and distribution of nitrosomonas europaea and nitrobacter winogradskyi after long-term operation of an autotrophic nitrifying biofilm reactor

  Mastroleo, F., Arnau, C., Verbeelen, T., Ahmed, M., Gòdia, F., Leys, N. & Van Houdt, R., 9 Mar 2022, In: Applied Microbiology. 2, 1, p. 272-287 16 p., 201002.

  Research output › peer-review

  Open Access

  File
  128 Downloads (Pure)

• Molecular Mechanisms Underlying Bacterial Uranium Resistance

  Rogiers, T., Van Houdt, R., Williamson, A., Leys, N., Boon, N. & Mijnendonckx, K., 10 Mar 2022, In: Frontiers in Microbiology. 13, p. 1-19 19 p., 822197.

  Research output › peer-review

  Open Access

• Optimization of RNA extraction for bacterial whole transcriptome studies of low-biomass samples

  Verbeelen, T., Van Houdt, R., Leys, N., Ganigué, R. & Mastroleo, F., 9 Oct 2022, (Accepted/In press) In: iScience. 25, p. 1-20 20 p., 105311.

  Research output › peer-review

• pH and microbial community determine the denitrifying activity in the presence of nitrate-containing radioactive waste

  Mijnendonckx, K., Bleyen, N., Van Gompel, A., Coninx, I. & Leys, N., 21 Oct 2022, In: Frontiers in Microbiology. p. 1-17 17 p., 968220.

  Research output › peer-review

  Open Access

  File
  65 Downloads (Pure)

• Space omics research in Europe - Contributions, geographical distribution and ESA member state funding schemes

  Deane, C. S., Mastroleo, F., Leys, N., da Silveira, W. A. & Herranz, R., 18 Mar 2022, In: iScience. 25, 3, p. 1-18 18 p., 103920.

  Research output › peer-review

  Open Access
• 2021

  Accurate prediction of metagenome‑assembled genome completeness by MAGISTA, a random forest model built on alignment‑free intra‑bin statistics

  Goussarov, G., Claesen, J., Ahmed, M., Leys, N., Vandamme, P. & Van Houdt, R., 5 Mar 2021, In: Environmental Microbiome. 17, 9, p. 1-13 13 p.

  Research output › peer-review

  Open Access

  File
  26 Downloads (Pure)

• Adaptation of Cupriavidus metallidurans CH34 to Toxic Zinc Concentrations Involves an Uncharacterized ABC-Type Transporter

  Van Houdt, R., Vandecraen, J., Leys, N., Monsieurs, P. & Aertsen, A., 2 Feb 2021, In: Microorganisms. 9, 2, p. 1-14 14 p., 9020309.

  Research output › peer-review

  Open Access

• Cyclical patterns affect microbial dynamics in the water basin of a nuclear research reactor

  Van Eesbeeck, V., Props, R., Ahmed, M. M., Petit, P., Rivasseau, C., Armengaud, J., Monsieur, P., Mahillon, J. & Leys, N., 15 Oct 2021, In: Frontiers in Microbiology. p. 1-11 11 p., 744115.

  Research output › peer-review

  Open Access

• Genetic Responses of Metabolically Active Limnospira indica Strain PCC 8005 Exposed to gamma-Radiation during Its Lifecycle

  Yadav, A., Maertens, L., Meese, T., Van Nieuwerburgh, F., Ahmed, M., Leys, N., Cuypers, A. & Janssen, P., 30 Jul 2021, In: Microorganisms. 9, 8, p. 1-32 32 p., 1626.

  Research output › peer-review

  Open Access

• Intestinal mucositis precedes dysbiosis in a mouse model for pelvic irradiation

  Segers, C., Ahmed, M., Claesen, J., Baatout, S., Leys, N., Lebeer, S., Verslegers, M. & Mastroleo, F., 10 Jun 2021, In: ISME Communications. 1, p. 1-10 10 p., 24.

  Research output › peer-review

  Open Access

• Microbially-Enhanced Vanadium Mining and Bioremediation Under Micro- and Mars Gravity on the International Space Station

  Cockell, C. S., Santomartino, R., Finster, K., Waajen, A. C., Nicholson, N., Loudon, C.-M., Eades, L. J., Moeller, R., Rettberg, P., Fuchs, F., Van Houdt, R., Leys, N., Coninx, I., Hatton, J., Parmitano, L., Krause, J., Koehler, A., Caplin, N., Zuijderduijn, L. & Mariani, A. & 15 others, Pellari, S. S., Carubia, F., Luciani, G., Balsamo, M., Zolesi, V., Zolesi, V., Ochoa, J., Sen, P., Watt, J. A. J., Doswald-Winkler, J., Herova, M., Rattenbacher, B., Wadsworth, J., Everroad, C. R. & Demets, R., 1 Apr 2021, In: Frontiers in Microbiology. p. 1-15 15 p.

  Research output › peer-review

  Open Access

• Phenotypic and Genetic Characterization of Temperature-Induced Mutagenesis and Mortality in Cupriavidus metallidurans

  Van Houdt, R., Vandecraen, J., Heylen, W., Leys, N., Monsieurs, P., Provoost, A. & Aertsen, A., 9 Jul 2021, In: Frontiers in Microbiology. 12, p. 1-9 9 p., 698330.

  Research output › peer-review

  Open Access

• Photobioreactor Limnospira indica Growth Model: Application From the MELiSSA Plant Pilot Scale to ISS Flight Experiment

  Poughon, L., Creuly, C., Gòdia, F., Leys, N. & Dussap, C.-G., 25 Aug 2021, In: Frontiers in Astronomy and Space Sciences. 8, p. 1-11 11 p., 700277.

  Research output › peer-review

  Open Access

• Soil microbial community structure and functionality changes in response to long-term metal and radionuclide pollution

  Rogiers, T., Claesen, J., Van Gompel, A., Vanhoudt, N., Ahmed, M., Williamson, A., Leys, N., Van Houdt, R., Boon, N. & Mijnendonckx, K., 1 Mar 2021, In: Environmental Microbiology. 23, 3, p. 1670-1683 14 p.

  Research output › peer-review

  Open Access
• 2020

  Copper resistance mediates long-term survival of Cupriavidus metallidurans in wet contact with metallic copper

  Maertens, L., Coninx, I., Claesen, J., Leys, N., Matroule, J.-Y. & Van Houdt, R., 3 Jun 2020, In: Frontiers in Microbiology. p. 1-11 11 p.

  Research output › peer-review

  Open Access

• Growth of Lactobacillus reuteri DSM17938 Under Two Simulated Microgravity Systems: Changes in Reuterin Production, Gastrointestinal Passage Resistance, and Stress Genes Expression Response

  Senatore, G., Mastroleo, F., Leys, N. & Mauriello, G., 1 Jan 2020, In: Astrobiology. 20, 1, p. 1-14 14 p.

  Research output › peer-review

  Open Access

• Limnospira indica PCC8005 growth in photobioreactor: model and simulation of the ISS and ground experiments

  Poughon, L., Laroche, C., Creuly, C., Paillé, C., Lasseur, C., Monsieurs, P., Heylen, W., Coninx, I., Mastroleo, F. & Leys, N., 1 May 2020, In: Life Sciences in Space Research. 25, p. 53-65 13 p.

  Research output › peer-review

  Open Access

• No Effect of Microgravity and Simulated Mars Gravity on Final Bacterial Cell Concentrations on the International Space Station: Applications to Space Bioproduction

  Santomartino, R., Waajen, A. C., de Wit, W., Parmitano, L., Loudon, C.-M., Moeller, R., Rettberg, P., Fuchs, F., Van Houdt, R., Finster, K., Coninx, I., Krause, J., Koehler, A., Caplin, N., Zuijderduijn, L., Zolesi, V., Balsamo, M., Mariani, A., Pellari, S. S. & Carubia, F. & 9 others, Luciani, G., Leys, N., Doswald-Winkler, J., Herova, M., Wadsworth, J., Everroad, C. R., Rattenbacher, B., Demets, R. & Cockell, C. S., 14 Oct 2020, In: Frontiers in Microbiology. p. 1-15 15 p., 579156.

  Research output › peer-review

  Open Access

• PaSiT: a novel approach based on short-oligonucleotide frequencies for efficient bacterial identification and typing

  Goussarov, G., Cleenwerck, I., Ahmed, M., Leys, N., Monsieurs, P., Tahon, G., Carlier, A., Vandamme, P. & Van Houdt, R., 3 Jan 2020, In: Bioinformatics. p. 1-8 8 p., 964.

  Research output › peer-review

  Open Access

• Space station biomining experiment demonstrates rare earth element extraction in microgravity and Mars gravity

  Cockell, C. S., Santomartino, R., Finster, K., Waajen, A. C., Eades, L. J., Moeller, R., Rettberg, P., Fuchs, F., Van Houdt, R., Leys, N., Coninx, I., Hatton, J., Parmitano, L., Krause, J., Koehler, A., Caplin, N., Zuijderduijn, L., Demets, R., Mariani, A. & Pellari, S. S. & 9 others, Carubia, F., Luciani, G., Balsamo, M., Zolesi, V., Doswald-Winkler, J., Herova, M., Rattenbacher, B., Wadsworth, J. & Everroad, C. R., 10 Nov 2020, In: Nature Communications. 11, p. 1-11 11 p., 5523.

  Research output › peer-review

  Open Access

• The transcriptomic landscape of Cupriavidus metallidurans CH34 acutely exposed to copper

  Maertens, L., Leys, N., Matroule, J.-Y. & Van Houdt, R., 4 Sep 2020, In: Genes. 11, 9, p. 1-24 24 p., 1049.

  Research output › peer-review

  Open Access

• Water-soluble bitumen degradation products can fuel nitrate reduction from non-radioactive bituminized waste

  Mijnendonckx, K., Van Gompel, A., Coninx, I., Bleyen, N. & Leys, N., 11 Jan 2020, In: Applied Geochemistry. 114, p. 1-11 11 p., 104525.

  Research output › peer-review

  Open Access
• 2019

  An active microbial community in Boom Clay pore water collected from piezometers impedes validating predictive modelling of ongoing geochemical processes

  Mijnendonckx, K., Honty, M., Wang, L., Jacops, E., Provoost, A., Ahmed, M. M., Wouters, K., De Craen, M. & Leys, N., 17 May 2019, In: Applied Geochemistry. 106, p. 149-160

  Research output › peer-review

  Open Access

• Fungi and Mycotoxins in Space - A Review

  De Middeleer, G., Leys, N., Sas, B. & De Saeger, S., 11 Apr 2019, In: Astrobiology. 19, 7, p. 1-12 12 p.

  Research output › peer-review

  Open Access

• Gene expansion and positive selection as bacterial adaptations to oligotrophic conditions

  Props, R., Monsieurs, P., Vandamme, P., Leys, N., Denef, V. J. & Boon, N., 6 Feb 2019, In: mSphere. 4, 1, 16 p., e00011-19 + Correction: e01143-20.

  Research output › peer-review

  Open Access

• Genomic and Transcriptomic Changes that Mediate Increased Platinum Resistance in Cupriavidus metallidurans

  Ali, M. M., Provoost, A., Maertens, L., Leys, N., Monsieurs, P., Charlier, D. & Van Houdt, R., 18 Jan 2019, In: Genes. 10, p. 1-22 22 p., 10010063.

  Research output › peer-review

• Helical and linear morphotypes of Arthrospira sp. PCC 8005 display genomic differences and respond differently to 60Co gamma irradiation

  Yadav, A., Monsieurs, P., Misztak, A., Waleron, K., Leys, N., Cuypers, A. & Janssen, P., 21 Nov 2019, In: European Journal of Phycology. p. 1-18 18 p.

  Research output › peer-review

  Open Access

• Reactivation of Microbial Strains and Synthetic Communities After a Spaceflight to the International Space Station: Corroborating the Feasibility of Essential Conversions in the MELiSSA Loop

  Ilgrande, C., Mastroleo, F., Christiaens, M. E. R., Lindeboom, R. E. F., Prat, D., Van Hoey, O., Ambrozova, I., Coninx, I., Heylen, W., Pommerening-Roser, A., Spieck, E., Boon, N., Vlaeminck, S. E., Leys, N. & Clauwaert, P., 4 Jun 2019, In: Astrobiology. 19, 9, 10 p.

  Research output › peer-review

  Open Access

• Spontaneous mutation in the AgrRS two-component regulatory system of Cupriavidus metallidurans results in enhanced silver resistance

  Mijnendonckx, K., Ali, M. M., Provoost, A., Janssen, P., Mergeay, M., Leys, N., Charlier, D., Monsieurs, P. & Van Houdt, R., 14 Oct 2019, In: Metallomics. p. 1912-1924 13 p.

  Research output › peer-review

  Open Access
• 2018

  BioRock: new experiments and hardware to investigate microbe–mineral interactions in space

  Loudon, C.-M., Nicholson, N., Finster, K., Leys, N., Byloos, B., Van Houdt, R., Rettberg, P., Moeller, R., Fuchs, F., Demets, R., Krause, J., Vukich, M., Mariani, A. & Cockell, C., 1 Oct 2018, In: International Journal of Astrobiology. 17, 4, p. 303-313 11 p.

  Research output › peer-review

• Characterization of the bacterial communities on recent Icelandic volcanic deposits of different ages

  Byloos, B., Monsieurs, P., Ahmed, M., Leys, N., Boon, N. & Van Houdt, R., 24 Sep 2018, In: BMC Microbiology. 11 p., 18:122.

  Research output › peer-review

  Open Access

• Cupriavidus metallidurans strains with different mobilomes and from distinct environments have comparable phenomes

  Van Houdt, R., Provoost, A., Van Assche, A., Leys, N., Lievens, B., Mijnendonckx, K. & Monsieurs, P., 18 Oct 2018, In: Genes. 9, 10, 23 p., 507.

  Research output › peer-review

  Open Access

• Effect of microgravity & space radiation on microbes

  Senatore, G., Mastroleo, F., Leys, N. & Mauriello, G., 10 May 2018, In: Future Microbiology. 13, 7, p. 831–847 18 p.

  Research output › peer-review