161Tb Purification by High Performance Ion Chromatography (HPIC) from Irradiated 160Gd

Maarten Ooms; Bernard Ponsard; Andrew Burgoyne; Dennis Elema; Thomas Cardinaels

doi:10.1007/s00259-019-04486-2

161Tb Purification by High Performance Ion Chromatography (HPIC) from Irradiated 160Gd

Maarten Ooms, Bernard Ponsard, Andrew Burgoyne, Dennis Elema, Thomas Cardinaels

Radiochemistry

Research output › peer-review

Abstract

161Tb has many attractive properties (halflife of 6.9 d, β- decay energy of 593 keV, conversion and Auger electron emission) for targeted radionuclide therapy with peptides and antibodies [1]. 161Tb can be produced via neutron irradiation of 160Gd in a nuclear reactor, such as BR2 (flux of circa 1014 neutrons cm-2 s-1) at SCK•CEN. The aim of this project was to develop a fast and easy method to purify small amounts (circa 250 MBq) of n.c.a. 161Tb with high specific activity, for radiolabeling studies and in-house chelator design.

Original language	English
Title of host publication	Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain
Pages	S40
Number of pages	1
Volume	46
DOIs	https://doi.org/10.1007/s00259-019-04486-2
State	Published - 31 Dec 2019
Event	2019 - EANM: European Association of Nuclear Medicine - Barcelona, Barcelona Duration: 12 Oct 2019 → 16 Oct 2019 https://eanm19.eanm.org/ https://eanm19.eanm.org https://www.efomp.org/index.php?r=events/view&id=83

Publication series

Name	European Journal of Nuclear Medicine and Molecular Imaging
Publisher	Springer
ISSN (Print)	1619-7070

Conference

Conference	2019 - EANM
Abbreviated title	EANM
Country/Territory	Spain
City	Barcelona
Period	2019-10-12 → 2019-10-16
Internet address	https://eanm19.eanm.org/ https://eanm19.eanm.org https://www.efomp.org/index.php?r=events/view&id=83

Access to Document

10.1007/s00259-019-04486-2License: Unspecified

Cite this

Ooms, M., Ponsard, B., Burgoyne, A., Elema, D., & Cardinaels, T. (2019). 161Tb Purification by High Performance Ion Chromatography (HPIC) from Irradiated 160Gd. In Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain (Vol. 46, pp. S40). (European Journal of Nuclear Medicine and Molecular Imaging). https://doi.org/10.1007/s00259-019-04486-2

@inproceedings{b88f334b4eeb4d50ba60f5ec6e51247a,

title = "161Tb Purification by High Performance Ion Chromatography (HPIC) from Irradiated 160Gd",

abstract = "161Tb has many attractive properties (halflife of 6.9 d, β- decay energy of 593 keV, conversion and Auger electron emission) for targeted radionuclide therapy with peptides and antibodies [1]. 161Tb can be produced via neutron irradiation of 160Gd in a nuclear reactor, such as BR2 (flux of circa 1014 neutrons cm-2 s-1) at SCK•CEN. The aim of this project was to develop a fast and easy method to purify small amounts (circa 250 MBq) of n.c.a. 161Tb with high specific activity, for radiolabeling studies and in-house chelator design.",

keywords = "Chromatography, 161Tb, Radionuclide therapy",

author = "Maarten Ooms and Bernard Ponsard and Andrew Burgoyne and Dennis Elema and Thomas Cardinaels",

note = "Score=5; 2019 - EANM : European Association of Nuclear Medicine, EANM ; Conference date: 12-10-2019 Through 16-10-2019",

year = "2019",

month = dec,

day = "31",

doi = "10.1007/s00259-019-04486-2",

language = "English",

volume = "46",

series = "European Journal of Nuclear Medicine and Molecular Imaging",

publisher = "Springer",

pages = "S40",

booktitle = "Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain",

url = "https://eanm19.eanm.org/, https://eanm19.eanm.org, https://www.efomp.org/index.php?r=events/view&id=83",

}

Ooms, M , Ponsard, B, Burgoyne, A, Elema, D & Cardinaels, T 2019, 161Tb Purification by High Performance Ion Chromatography (HPIC) from Irradiated 160Gd. in Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain. vol. 46, European Journal of Nuclear Medicine and Molecular Imaging, pp. S40, 2019 - EANM, Barcelona, Spain, 2019-10-12. https://doi.org/10.1007/s00259-019-04486-2

TY - GEN

T1 - 161Tb Purification by High Performance Ion Chromatography (HPIC) from Irradiated 160Gd

AU - Ooms, Maarten

AU - Ponsard, Bernard

AU - Burgoyne, Andrew

AU - Elema, Dennis

AU - Cardinaels, Thomas

N1 - Score=5

PY - 2019/12/31

Y1 - 2019/12/31

N2 - 161Tb has many attractive properties (halflife of 6.9 d, β- decay energy of 593 keV, conversion and Auger electron emission) for targeted radionuclide therapy with peptides and antibodies [1]. 161Tb can be produced via neutron irradiation of 160Gd in a nuclear reactor, such as BR2 (flux of circa 1014 neutrons cm-2 s-1) at SCK•CEN. The aim of this project was to develop a fast and easy method to purify small amounts (circa 250 MBq) of n.c.a. 161Tb with high specific activity, for radiolabeling studies and in-house chelator design.

AB - 161Tb has many attractive properties (halflife of 6.9 d, β- decay energy of 593 keV, conversion and Auger electron emission) for targeted radionuclide therapy with peptides and antibodies [1]. 161Tb can be produced via neutron irradiation of 160Gd in a nuclear reactor, such as BR2 (flux of circa 1014 neutrons cm-2 s-1) at SCK•CEN. The aim of this project was to develop a fast and easy method to purify small amounts (circa 250 MBq) of n.c.a. 161Tb with high specific activity, for radiolabeling studies and in-house chelator design.

KW - Chromatography

KW - 161Tb

KW - Radionuclide therapy

UR - https://ecm.sckcen.be/OTCS/llisapi.dll/open/38089858

U2 - 10.1007/s00259-019-04486-2

DO - 10.1007/s00259-019-04486-2

M3 - In-proceedings paper

VL - 46

T3 - European Journal of Nuclear Medicine and Molecular Imaging

SP - S40

BT - Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain

T2 - 2019 - EANM

Y2 - 12 October 2019 through 16 October 2019

ER -