A dose rate independent 2D Ce-doped YAG scintillating dosimetry system for time resolved beam monitoring in ultra-high dose rate electron “FLASH” radiation therapy

Verdi Vanreusel; Sophie Heinrich; Thomas De Kerf; Paul Leblans; Dirk Vandenbroucke; Steve Vanlanduit; Dirk Verellen; Alessia Gasparini; Luana de Freitas Nascimento

doi:10.1016/j.sna.2024.115313

A dose rate independent 2D Ce-doped YAG scintillating dosimetry system for time resolved beam monitoring in ultra-high dose rate electron “FLASH” radiation therapy

Verdi Vanreusel, Sophie Heinrich, Thomas De Kerf, Paul Leblans, Dirk Vandenbroucke, Steve Vanlanduit, Dirk Verellen, Alessia Gasparini, Luana de Freitas Nascimento

Research output › peer-review

Abstract

Preclinical studies have shown that radiotherapy treatments benefit from ultra-high dose rate (UHDR) irradiations. These trigger the FLASH-effect, resulting in a strong decrease in normal tissue toxicity with conserved tumor control probability, compared with conventional irradiations. However, the beam parameters to trigger the FLASH-effect and the radiobiological mechanisms behind it remain to be elucidated. A limiting factor in many studies is the lack of accurate real time dosimetry. In this work an innovative solution for 2D real time dosimetry in UHDR electron beams is presented and characterized. The in-house developed ImageDosis system consists of a scientific camera, with high temporal resolution, and a coating, containing 12% of Y₃Al₅O₁₂:Ce³⁺ as scintillating material. Reference dosimetry was performed by means of radiochromic film, and a (C₃₈H₃₄P₂)MnBr₄ point scintillator was used to validate the pulse discrimination properties of the ImageDosis system. Irradiations were performed in two centers (Antwerp and Orsay), with an ElectronFlash accelerator. The ImageDosis system was tested with varying number of pulses, pulse length, pulse repetition frequency (PRF) and energy. In addition, its temporal resolution and 2D properties were investigated. The ImageDosis system showed negligible dose, dose rate and energy dependence for doses up to 13 Gy and average dose rates up to 140 Gy/s, with a dose per pulse up to 2 Gy and a PRF up to 300 Hz. The system is capable of discriminating and measuring the dose of individual pulses and shows promising 2D characteristics that need further optimization.

Original language	English
Article number	115313
Number of pages	10
Journal	Sensors and Actuators A: Physical
Volume	371
DOIs	https://doi.org/10.1016/j.sna.2024.115313
State	Published - 1 Jun 2024

Funding

The authors wish to acknowledge the university hospital of Antwerp (UZA), Belgium for providing the infrastructure needed to perform this work. In addition, this work was supported by VLAIO via the Flanders.HealthTech call, Belgium [HBC.2021.0946] and by FWO via the Tournesol, Belgium grant [VS00823N]. SCK CEN and Iridium Network are also non-funded collaborators to the 18HLT04 UHDpulse project which received funding from the EMPIR programme. The authors wish to acknowledge the university hospital of Antwerp (UZA) for providing the infrastructure needed to perform this work. In addition, this work was supported by VLAIO via the Flanders.HealthTech call [ HBC.2021.0946 ] and by FWO via the Tournesol grant [ VS00823N ]. SCK CEN and Iridium Network are also non-funded collaborators to the 18HLT04 UHDpulse project which received funding from the EMPIR programme.

Funders	Funder number
EMPIR - European Metrology Programme for Innovation and Research
Fonds Wetenschappelijk Onderzoek	VS00823N

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering

Access to Document

10.1016/j.sna.2024.115313

Cite this

Vanreusel, V., Heinrich, S., De Kerf, T., Leblans, P., Vandenbroucke, D., Vanlanduit, S., Verellen, D., Gasparini, A., & de Freitas Nascimento, L. (2024). A dose rate independent 2D Ce-doped YAG scintillating dosimetry system for time resolved beam monitoring in ultra-high dose rate electron “FLASH” radiation therapy. Sensors and Actuators A: Physical, 371, Article 115313. https://doi.org/10.1016/j.sna.2024.115313

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abstract = "Preclinical studies have shown that radiotherapy treatments benefit from ultra-high dose rate (UHDR) irradiations. These trigger the FLASH-effect, resulting in a strong decrease in normal tissue toxicity with conserved tumor control probability, compared with conventional irradiations. However, the beam parameters to trigger the FLASH-effect and the radiobiological mechanisms behind it remain to be elucidated. A limiting factor in many studies is the lack of accurate real time dosimetry. In this work an innovative solution for 2D real time dosimetry in UHDR electron beams is presented and characterized. The in-house developed ImageDosis system consists of a scientific camera, with high temporal resolution, and a coating, containing 12% of Y3Al5O12:Ce3+ as scintillating material. Reference dosimetry was performed by means of radiochromic film, and a (C38H34P2)MnBr4 point scintillator was used to validate the pulse discrimination properties of the ImageDosis system. Irradiations were performed in two centers (Antwerp and Orsay), with an ElectronFlash accelerator. The ImageDosis system was tested with varying number of pulses, pulse length, pulse repetition frequency (PRF) and energy. In addition, its temporal resolution and 2D properties were investigated. The ImageDosis system showed negligible dose, dose rate and energy dependence for doses up to 13 Gy and average dose rates up to 140 Gy/s, with a dose per pulse up to 2 Gy and a PRF up to 300 Hz. The system is capable of discriminating and measuring the dose of individual pulses and shows promising 2D characteristics that need further optimization.",

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Vanreusel, V, Heinrich, S, De Kerf, T, Leblans, P, Vandenbroucke, D, Vanlanduit, S, Verellen, D, Gasparini, A & de Freitas Nascimento, L 2024, 'A dose rate independent 2D Ce-doped YAG scintillating dosimetry system for time resolved beam monitoring in ultra-high dose rate electron “FLASH” radiation therapy', Sensors and Actuators A: Physical, vol. 371, 115313. https://doi.org/10.1016/j.sna.2024.115313

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AU - Leblans, Paul

AU - Vandenbroucke, Dirk

AU - Vanlanduit, Steve

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