A dose rate independent 2D Ce-doped YAG scintillating dosimetry system for time resolved beam monitoring in ultra-high dose rate electron “FLASH” radiation therapy

Verdi Vanreusel, Sophie Heinrich, Thomas De Kerf, Paul Leblans, Dirk Vandenbroucke, Steve Vanlanduit, Dirk Verellen, Alessia Gasparini, Luana de Freitas Nascimento

Research outputpeer-review

Abstract

Preclinical studies have shown that radiotherapy treatments benefit from ultra-high dose rate (UHDR) irradiations. These trigger the FLASH-effect, resulting in a strong decrease in normal tissue toxicity with conserved tumor control probability, compared with conventional irradiations. However, the beam parameters to trigger the FLASH-effect and the radiobiological mechanisms behind it remain to be elucidated. A limiting factor in many studies is the lack of accurate real time dosimetry. In this work an innovative solution for 2D real time dosimetry in UHDR electron beams is presented and characterized. The in-house developed ImageDosis system consists of a scientific camera, with high temporal resolution, and a coating, containing 12% of Y3Al5O12:Ce3+ as scintillating material. Reference dosimetry was performed by means of radiochromic film, and a (C38H34P2)MnBr4 point scintillator was used to validate the pulse discrimination properties of the ImageDosis system. Irradiations were performed in two centers (Antwerp and Orsay), with an ElectronFlash accelerator. The ImageDosis system was tested with varying number of pulses, pulse length, pulse repetition frequency (PRF) and energy. In addition, its temporal resolution and 2D properties were investigated. The ImageDosis system showed negligible dose, dose rate and energy dependence for doses up to 13 Gy and average dose rates up to 140 Gy/s, with a dose per pulse up to 2 Gy and a PRF up to 300 Hz. The system is capable of discriminating and measuring the dose of individual pulses and shows promising 2D characteristics that need further optimization.

Original languageEnglish
Article number115313
Number of pages10
JournalSensors and Actuators A: Physical
Volume371
DOIs
StatePublished - 1 Jun 2024

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering

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