A historical perspective and cellular regulation of megakaryocytopoiesis

    Research outputpeer-review

    Abstract

    With the recent accumulation of information about megakaryocyte biochemistry and function, our understanding of the regulatory system controlling megakaryocytopoiesis is becoming more clear. The cloning and the expression of thrombopoietin, the regulator of megakaryocytopoiesis, has been a major breakthrough. This review will discuss megakaryocyte ontogeny, cell-cell interactions between megakaryocytes and the other stromal cells and the signal transduction in megakaryocytes.

    Original languageEnglish
    Pages (from-to)67-79
    Number of pages13
    JournalHaematologia
    Volume29
    Issue number2
    StatePublished - 1998

    ASJC Scopus subject areas

    • Hematology

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