A multi-region model of mouse kidney tissues for preclinical small-scale dosimetry of beta- and alpha-particle emitting radiopharmaceuticals

Clarita Saldarriaga Vargas; Lara Struelens; Matthias D'huyvetter; Vicky Caveliers; Peter Covens

A multi-region model of mouse kidney tissues for preclinical small-scale dosimetry of beta- and alpha-particle emitting radiopharmaceuticals

Clarita Saldarriaga Vargas, Lara Struelens, Matthias D'huyvetter, Vicky Caveliers, Peter Covens

RDA-TRNT

Research output › peer-review

Abstract

Absorbed dose heterogeneity is a major modifier of tissue response which can confound the analysis and prediction of toxicity in radiopharmaceutical therapy. Preclinical nephrotoxicity studies with detailed dosimetry of kidney tissues are useful to investigate the dose-response relationship of alpha- and beta-particle emitting radioligands with a non-uniform distribution in kidney tissues and provide insight on the translatability of the dose-response relationships of different radiopharmaceuticals. Such analyses are however limited by the scarcity of reference S coefficients (absorbed dose in target tissue per radionuclide decay in source tissue) available in the literature for various tissues of the mouse kidney.

Original language	English
Title of host publication	Meeting ReportMolecular Targeting Probes-Radioactive & Nonradioactive - Dosimetry & Image Analysis
Publisher	SNMMI - Society of Nuclear Medicine and Molecular Imaging
Number of pages	1
State	Published - Jun 2024
Event	2024 - SNMMI: Annual Meeting Exhibits and Sponsorship - Toronto Duration: 8 Jun 2024 → 11 Jun 2024

Publication series

Name	The journal of nuclear medicine
Publisher	SNMMI
Number	Supplement 2
Volume	65

Conference

Conference	2024 - SNMMI
Country/Territory	Canada
City	Toronto
Period	2024-06-08 → 2024-06-11

Access to Document

https://jnm.snmjournals.org/content/65/supplement_2/241066License: Unspecified

Cite this

Saldarriaga Vargas, C., Struelens, L., D'huyvetter, M., Caveliers, V., & Covens, P. (2024). A multi-region model of mouse kidney tissues for preclinical small-scale dosimetry of beta- and alpha-particle emitting radiopharmaceuticals. In Meeting ReportMolecular Targeting Probes-Radioactive & Nonradioactive - Dosimetry & Image Analysis Article 241066 (The journal of nuclear medicine; Vol. 65, No. Supplement 2). SNMMI - Society of Nuclear Medicine and Molecular Imaging. https://jnm.snmjournals.org/content/65/supplement_2/241066

Saldarriaga Vargas, Clarita ; Struelens, Lara ; D'huyvetter, Matthias et al. / A multi-region model of mouse kidney tissues for preclinical small-scale dosimetry of beta- and alpha-particle emitting radiopharmaceuticals. Meeting ReportMolecular Targeting Probes-Radioactive & Nonradioactive - Dosimetry & Image Analysis. SNMMI - Society of Nuclear Medicine and Molecular Imaging, 2024. (The journal of nuclear medicine; Supplement 2).

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title = "A multi-region model of mouse kidney tissues for preclinical small-scale dosimetry of beta- and alpha-particle emitting radiopharmaceuticals",

abstract = "Absorbed dose heterogeneity is a major modifier of tissue response which can confound the analysis and prediction of toxicity in radiopharmaceutical therapy. Preclinical nephrotoxicity studies with detailed dosimetry of kidney tissues are useful to investigate the dose-response relationship of alpha- and beta-particle emitting radioligands with a non-uniform distribution in kidney tissues and provide insight on the translatability of the dose-response relationships of different radiopharmaceuticals. Such analyses are however limited by the scarcity of reference S coefficients (absorbed dose in target tissue per radionuclide decay in source tissue) available in the literature for various tissues of the mouse kidney.",

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author = "{Saldarriaga Vargas}, Clarita and Lara Struelens and Matthias D'huyvetter and Vicky Caveliers and Peter Covens",

note = "Score=3; 2024 - SNMMI : Annual Meeting Exhibits and Sponsorship ; Conference date: 08-06-2024 Through 11-06-2024",

year = "2024",

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language = "English",

series = "The journal of nuclear medicine",

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Saldarriaga Vargas, C , Struelens, L , D'huyvetter, M, Caveliers, V & Covens, P 2024, A multi-region model of mouse kidney tissues for preclinical small-scale dosimetry of beta- and alpha-particle emitting radiopharmaceuticals. in Meeting ReportMolecular Targeting Probes-Radioactive & Nonradioactive - Dosimetry & Image Analysis., 241066, The journal of nuclear medicine, no. Supplement 2, vol. 65, SNMMI - Society of Nuclear Medicine and Molecular Imaging, 2024 - SNMMI, Toronto, Canada, 2024-06-08. <https://jnm.snmjournals.org/content/65/supplement_2/241066>

A multi-region model of mouse kidney tissues for preclinical small-scale dosimetry of beta- and alpha-particle emitting radiopharmaceuticals. / Saldarriaga Vargas, Clarita ; Struelens, Lara ; D'huyvetter, Matthias et al.
Meeting ReportMolecular Targeting Probes-Radioactive & Nonradioactive - Dosimetry & Image Analysis. SNMMI - Society of Nuclear Medicine and Molecular Imaging, 2024. 241066 (The journal of nuclear medicine; Vol. 65, No. Supplement 2).

Research output › peer-review

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AU - Struelens, Lara

AU - D'huyvetter, Matthias

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AU - Covens, Peter

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M3 - In-proceedings paper

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BT - Meeting ReportMolecular Targeting Probes-Radioactive & Nonradioactive - Dosimetry & Image Analysis

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Saldarriaga Vargas C , Struelens L , D'huyvetter M, Caveliers V, Covens P. A multi-region model of mouse kidney tissues for preclinical small-scale dosimetry of beta- and alpha-particle emitting radiopharmaceuticals. In Meeting ReportMolecular Targeting Probes-Radioactive & Nonradioactive - Dosimetry & Image Analysis. SNMMI - Society of Nuclear Medicine and Molecular Imaging. 2024. 241066. (The journal of nuclear medicine; Supplement 2).