A survey on uncertainty in bioassay measurements carried out within the OMINEX project

Christian Hurtgen; Catherine Cossonnet

doi:10.1093/oxfordjournals.rpd.a006261

A survey on uncertainty in bioassay measurements carried out within the OMINEX project

Christian Hurtgen, Catherine Cossonnet

Research output › peer-review

Abstract

One of the topics covered by the project OMINEX (Optimisation of Monitoring for Internal Exposure) was to look at the bioassay measurements performed in the European laboratories. Questionnaires on bioassay measurements by alpha spectrometry or ICP-MS were sent to European Laboratories. The main objective was to collect information from laboratories on analytical procedures and on the uncertainties associated with bioassay results. Alpha spectrometry is the technique most used for the determination of alpha emitters such as actinides in biological samples (urine and faeces). ICP-MS is not yet used for routine measurements of actinides in biological samples, but is very sensitive for measurements of long lived radionuclides. The different parameters influencing the uncertainties on the results and the MDA have been investigated. Optimal conditions to achieve low results’ uncertainties and low MDA, for the measurements of actinides in biological samples are given for alpha spectrometry and ICP-MS.

Original language	English
Pages (from-to)	375-378
Number of pages	4
Journal	Radiation protection dosimetry
Volume	105
Issue number	1-4
DOIs	https://doi.org/10.1093/oxfordjournals.rpd.a006261
State	Published - 2003

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Cite this

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title = "A survey on uncertainty in bioassay measurements carried out within the OMINEX project",

abstract = "One of the topics covered by the project OMINEX (Optimisation of Monitoring for Internal Exposure) was to look at the bioassay measurements performed in the European laboratories. Questionnaires on bioassay measurements by alpha spectrometry or ICP-MS were sent to European Laboratories. The main objective was to collect information from laboratories on analytical procedures and on the uncertainties associated with bioassay results. Alpha spectrometry is the technique most used for the determination of alpha emitters such as actinides in biological samples (urine and faeces). ICP-MS is not yet used for routine measurements of actinides in biological samples, but is very sensitive for measurements of long lived radionuclides. The different parameters influencing the uncertainties on the results and the MDA have been investigated. Optimal conditions to achieve low results{\textquoteright} uncertainties and low MDA, for the measurements of actinides in biological samples are given for alpha spectrometry and ICP-MS.",

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AU - Cossonnet, Catherine

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AB - One of the topics covered by the project OMINEX (Optimisation of Monitoring for Internal Exposure) was to look at the bioassay measurements performed in the European laboratories. Questionnaires on bioassay measurements by alpha spectrometry or ICP-MS were sent to European Laboratories. The main objective was to collect information from laboratories on analytical procedures and on the uncertainties associated with bioassay results. Alpha spectrometry is the technique most used for the determination of alpha emitters such as actinides in biological samples (urine and faeces). ICP-MS is not yet used for routine measurements of actinides in biological samples, but is very sensitive for measurements of long lived radionuclides. The different parameters influencing the uncertainties on the results and the MDA have been investigated. Optimal conditions to achieve low results’ uncertainties and low MDA, for the measurements of actinides in biological samples are given for alpha spectrometry and ICP-MS.

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KW - Bioassay Measurements

KW - OMINEX project

KW - Alpha spectrometry

KW - ICP-MS

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