About histone H1 phosphorylation during mitosis

How a cell controls its proliferation is a question of fundamental importance to both biological and medical sciences. The role of protein phosphorylation as a primary control mechanism for cell cycle progression has been demonstrated by genetic studies that have identified the family of cyclin-dependent kinases (CDKs) that are necessary for cell cycle progression. CDKs are composed of catalytic and regulatory subunits and their activity is controlled through post-translational modification of these subunits and by association with inhibitor proteins (1, 2). Activation of CDKs requires their association with proteins, called cyclins, dephosphorylation of the neighboring T14 and Y15 (for CDK1) and phosphorylation of a T161.