Abstract
Free and specific activities of acid DNAase have been measured in the thymus and regenerating liver of rats after 700 r whole-body x-irradiation. Labilization of DNA has been evaluated in the same organs by the amount of DNA extracted in solution of increasing concentrations of sodium trichloracetate. The increase in DNAase specific activity observed in irradiated thymus is associated with increasing lability of the DNA-protein bonds. In normal regenerating liver, the specific activity of acid DNAase also increases, and this rise of enzyme activity is paralleled by an increased labilization of DNA. Irradiation of regenerating liver does not result in a further increase of acid DNAase specific activity, nor in a greater lability of DNA. Possible correlations between these changes and the cytological alterations after irradiation are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 51-58 |
| Number of pages | 8 |
| Journal | International Journal of Radiation Biology |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1964 |
| Externally published | Yes |
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Radiology Nuclear Medicine and imaging