An isotope dilution mass spectrometry overview: tips and applications for the measurement of radionuclides

Alexandre Quemet, Amélie Hubert, Alkiviadis Gourgiotis, Ana María Sánchez Hernández, Marielle Crozet, Guillaume Bailly, Andrew Dobney, Georges Duhamel, Joe Hiess, Urska Repinc, Sébastien Mialle, Béatrice Boulet, Raphaëlle Escoube, Céline Bouvier-Capely, Fabien Pointurier, Sébastien Picart

Research outputpeer-review


This article proposes a practical guide including good laboratory practices followed by a critical review about the application of isotope dilution mass spectrometry (ID-MS) measurement to radionuclide analyses. Several national and international scientific institutions (French Alternative Energies and Atomic Energy Commission, French Radioprotection and Nuclear Safety Institute, European Commission, International Atomic Energy Agency, and Belgian Nuclear Research Centre) participated in this review by sharing their good laboratory practices. ID-MS is one of the primary ratio methods of measurement in the International System of Units. It can produce highly accurate results, as potential sources of bias can be controlled. Many hints are given to obtain the best performance. In addition, a script written with the open source software Octave is provided to calculate the optimal parameters of the {sample-spike} mixture easily. Radionuclide analysis by ID-MS applies to many different fields (environmental, biological, reference materials, irradiated samples, process control, nuclear safeguards and nuclear forensics).

Original languageEnglish
Number of pages35
JournalJournal of Analytical Atomic Spectrometry
StatePublished - 6 May 2024

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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