Artificial intelligence for the development of Adverse Outcome Pathway (AOP) to assess neurodegenerative disorders following ionizing radiation exposure

Recent research on non-cancer effects of low to moderate doses of ionizing radiation (IR) has shown interest in and growing concern about cognitive and neurodegenerative effects. Adults exposed to doses from 1 to 2 Gy demonstrated cognitive decline, but research is limited and the effects of lower doses remain poorly studied. Associations between IR dose, dementia, Alzheimer's disease and Parkinson's disease were positively and significantly correlated in cohorts of nuclear workers [1, 2, 3, 4]. Development of adverse outcome pathways (AOPs) has recently gained wide interest as a framework with a strong potential to improve the understanding of putative biological modes of action of IR leading to diseases, including neurological disorders.