TY - JOUR
T1 - Biomarkers for biosensors to monitor space-induced cardiovascular ageing
AU - Rehnberg, Emil
AU - Quaghebeur, Katrijn
AU - Baselet, Bjorn
AU - Rajan, Nicholas
AU - Shazly, Tarek
AU - Moroni, Lorenzo
AU - Baatout, Sarah
AU - Tabury, Kevin
N1 - Score=10
PY - 2023/2/3
Y1 - 2023/2/3
N2 - Human presence in space has uncovered several health concerns related to the space environment that need to be addressed for future space missions. The hostile space
environment includes radiation and microgravity that cause various pathophysiological effects. Among them are conditions related to the cardiovascular system. The
cardiovascular system shows a dysfunctional and deconditioning state, similar to ageing on Earth, once exposed to the space environment. As we aim for longer space
missions to the Moon, Mars, and thus into deep space, better understanding, monitoring, and development of countermeasures for these accelerated ageing processes are necessary. Biomarkers and their integration into biosensors therefore become important tools to understand the underlying mechanisms, develop countermeasures
and monitor accelerated cardiovascular ageing. In this review, we will provide a brief overview of the space environment and its effects on the human cardiovascular system. We list the known potential cardiovascular ageing biomarkers relevant to space alongwith our current knowledge of the underlying mechanisms of cardiovascular ageing. We also explore in more details about the various biosensors used, their specifications, and how lab-on-a-chip systems are crucial to the development of these biosensors for tracking cardiovascular ageing during upcoming space missions.
AB - Human presence in space has uncovered several health concerns related to the space environment that need to be addressed for future space missions. The hostile space
environment includes radiation and microgravity that cause various pathophysiological effects. Among them are conditions related to the cardiovascular system. The
cardiovascular system shows a dysfunctional and deconditioning state, similar to ageing on Earth, once exposed to the space environment. As we aim for longer space
missions to the Moon, Mars, and thus into deep space, better understanding, monitoring, and development of countermeasures for these accelerated ageing processes are necessary. Biomarkers and their integration into biosensors therefore become important tools to understand the underlying mechanisms, develop countermeasures
and monitor accelerated cardiovascular ageing. In this review, we will provide a brief overview of the space environment and its effects on the human cardiovascular system. We list the known potential cardiovascular ageing biomarkers relevant to space alongwith our current knowledge of the underlying mechanisms of cardiovascular ageing. We also explore in more details about the various biosensors used, their specifications, and how lab-on-a-chip systems are crucial to the development of these biosensors for tracking cardiovascular ageing during upcoming space missions.
KW - Biosensors
KW - Space exploration
KW - Biomarkers
KW - Lab-on-chip
KW - Cardiovascular ageing
UR - https://ecm.sckcen.be/OTCS/llisapi.dll/open/53831130
U2 - 10.3389/fsens.2023.1015403
DO - 10.3389/fsens.2023.1015403
M3 - Article
SN - 2673-5067
JO - Frontiers in sensors
JF - Frontiers in sensors
M1 - 1015403
ER -