Brain calcification in a case of acute lymphoblastic leukaemia

Y. Michotte; J. Smeyers-Verbeke; G. Ebinger; R. Maurus; J. Pelsmaekers; A. Lowenthal; D. L. Massart

doi:10.1016/0022-510X(75)90136-7

Brain calcification in a case of acute lymphoblastic leukaemia

Y. Michotte, J. Smeyers-Verbeke, G. Ebinger, R. Maurus, J. Pelsmaekers, A. Lowenthal, D. L. Massart

Research output › peer-review

Abstract

Cortical calcifications, seen on X-ray in the brain of a child suffering from leukaemia, were submitted to morphological and chemical analysis. The morphology was studied by a combination of low temperature ashing and microscanning. The calcification principally affected axons and capillary walls and consisted of spherules amalgamated into hollow cylinders. The results of chemical analysis of the calcified material were compared to those obtained in a case of Fahr's disease. The mineral composition and structure of both types of calcification were similar, but the Mn concentration was higher in the case of Fahr's disease. X-ray diffraction showed that the calcification consisted of amorphous calcium phosphate and acid calcium orthophosphate, most probably precursors of hydroxyapatite.

Original language	English
Pages (from-to)	145-152
Number of pages	8
Journal	Journal of the Neurological Sciences
Volume	25
Issue number	2
DOIs	https://doi.org/10.1016/0022-510X(75)90136-7
State	Published - Jun 1975

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/0022-510X(75)90136-7

Cite this

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title = "Brain calcification in a case of acute lymphoblastic leukaemia",

abstract = "Cortical calcifications, seen on X-ray in the brain of a child suffering from leukaemia, were submitted to morphological and chemical analysis. The morphology was studied by a combination of low temperature ashing and microscanning. The calcification principally affected axons and capillary walls and consisted of spherules amalgamated into hollow cylinders. The results of chemical analysis of the calcified material were compared to those obtained in a case of Fahr's disease. The mineral composition and structure of both types of calcification were similar, but the Mn concentration was higher in the case of Fahr's disease. X-ray diffraction showed that the calcification consisted of amorphous calcium phosphate and acid calcium orthophosphate, most probably precursors of hydroxyapatite.",

author = "Y. Michotte and J. Smeyers-Verbeke and G. Ebinger and R. Maurus and J. Pelsmaekers and A. Lowenthal and Massart, {D. L.}",

year = "1975",

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T1 - Brain calcification in a case of acute lymphoblastic leukaemia

AU - Michotte, Y.

AU - Smeyers-Verbeke, J.

AU - Ebinger, G.

AU - Maurus, R.

AU - Pelsmaekers, J.

AU - Lowenthal, A.

AU - Massart, D. L.

PY - 1975/6

Y1 - 1975/6

N2 - Cortical calcifications, seen on X-ray in the brain of a child suffering from leukaemia, were submitted to morphological and chemical analysis. The morphology was studied by a combination of low temperature ashing and microscanning. The calcification principally affected axons and capillary walls and consisted of spherules amalgamated into hollow cylinders. The results of chemical analysis of the calcified material were compared to those obtained in a case of Fahr's disease. The mineral composition and structure of both types of calcification were similar, but the Mn concentration was higher in the case of Fahr's disease. X-ray diffraction showed that the calcification consisted of amorphous calcium phosphate and acid calcium orthophosphate, most probably precursors of hydroxyapatite.

AB - Cortical calcifications, seen on X-ray in the brain of a child suffering from leukaemia, were submitted to morphological and chemical analysis. The morphology was studied by a combination of low temperature ashing and microscanning. The calcification principally affected axons and capillary walls and consisted of spherules amalgamated into hollow cylinders. The results of chemical analysis of the calcified material were compared to those obtained in a case of Fahr's disease. The mineral composition and structure of both types of calcification were similar, but the Mn concentration was higher in the case of Fahr's disease. X-ray diffraction showed that the calcification consisted of amorphous calcium phosphate and acid calcium orthophosphate, most probably precursors of hydroxyapatite.

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