Calculation of decision threshold and detection limit in radiometric measurements using a Monte Carlo Method

Henrik Ramebäck; Leif A. Persson; Christian Ekberg; Petter Lindgren; Michel Bruggeman

doi:10.1016/j.apradiso.2019.108949

Calculation of decision threshold and detection limit in radiometric measurements using a Monte Carlo Method

Henrik Ramebäck, Leif A. Persson, Christian Ekberg, Petter Lindgren, Michel Bruggeman

Research output › peer-review

Abstract

Calculation of the decision threshold and detection limit of a measurement, or measurement method, are crucial in order to decide if an analyte is present or not and with what confidence it can be quantified. That decision is important in view of possible actions if something would be detected. In this work, a method for calculating these limits using a Monte Carlo method is presented. In the Monte Carlo method any a priori distribution (e.g. normal distribution, rectangular distribution, triangular distribution) of an input quantity can be selected. Differences between the Monte Carlo calculated characteristic limits and the ones calculated according to ISO 11929:2010 is presented. Moreover, suggestions how to calculate the detection limit when it can not be calculated according to the ISO 11929:2010 are given.

Original language	English
Article number	108949
Number of pages	5
Journal	Applied Radiation and Isotopes
Volume	156
DOIs	https://doi.org/10.1016/j.apradiso.2019.108949
State	Published - 1 Feb 2020

Access to Document

10.1016/j.apradiso.2019.108949

Cite this

@article{e5adac3361cd40cca4067461696bf74b,

title = "Calculation of decision threshold and detection limit in radiometric measurements using a Monte Carlo Method",

abstract = "Calculation of the decision threshold and detection limit of a measurement, or measurement method, are crucial in order to decide if an analyte is present or not and with what confidence it can be quantified. That decision is important in view of possible actions if something would be detected. In this work, a method for calculating these limits using a Monte Carlo method is presented. In the Monte Carlo method any a priori distribution (e.g. normal distribution, rectangular distribution, triangular distribution) of an input quantity can be selected. Differences between the Monte Carlo calculated characteristic limits and the ones calculated according to ISO 11929:2010 is presented. Moreover, suggestions how to calculate the detection limit when it can not be calculated according to the ISO 11929:2010 are given.",

keywords = "Decision threshold, Detection limit, Minimum detectable activity, MDA, Monte Carlo",

author = "Henrik Rameb{\"a}ck and Persson, {Leif A.} and Christian Ekberg and Petter Lindgren and Michel Bruggeman",

note = "Score=10",

year = "2020",

month = feb,

day = "1",

doi = "10.1016/j.apradiso.2019.108949",

language = "English",

volume = "156",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier",

}

TY - JOUR

T1 - Calculation of decision threshold and detection limit in radiometric measurements using a Monte Carlo Method

AU - Ramebäck, Henrik

AU - Persson, Leif A.

AU - Ekberg, Christian

AU - Lindgren, Petter

AU - Bruggeman, Michel

N1 - Score=10

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Calculation of the decision threshold and detection limit of a measurement, or measurement method, are crucial in order to decide if an analyte is present or not and with what confidence it can be quantified. That decision is important in view of possible actions if something would be detected. In this work, a method for calculating these limits using a Monte Carlo method is presented. In the Monte Carlo method any a priori distribution (e.g. normal distribution, rectangular distribution, triangular distribution) of an input quantity can be selected. Differences between the Monte Carlo calculated characteristic limits and the ones calculated according to ISO 11929:2010 is presented. Moreover, suggestions how to calculate the detection limit when it can not be calculated according to the ISO 11929:2010 are given.

AB - Calculation of the decision threshold and detection limit of a measurement, or measurement method, are crucial in order to decide if an analyte is present or not and with what confidence it can be quantified. That decision is important in view of possible actions if something would be detected. In this work, a method for calculating these limits using a Monte Carlo method is presented. In the Monte Carlo method any a priori distribution (e.g. normal distribution, rectangular distribution, triangular distribution) of an input quantity can be selected. Differences between the Monte Carlo calculated characteristic limits and the ones calculated according to ISO 11929:2010 is presented. Moreover, suggestions how to calculate the detection limit when it can not be calculated according to the ISO 11929:2010 are given.

KW - Decision threshold

KW - Detection limit

KW - Minimum detectable activity

KW - MDA

KW - Monte Carlo

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/36025479

U2 - 10.1016/j.apradiso.2019.108949

DO - 10.1016/j.apradiso.2019.108949

M3 - Article

SN - 0969-8043

VL - 156

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

M1 - 108949

ER -