TY - JOUR
T1 - Cardiovascular diseases related to ionizing radiation The risk of low-dose exposure
AU - Baselet, Bjorn
AU - Rombouts, Charlotte
AU - Benotmane, Rafi
AU - Baatout, Sarah
AU - Aerts, An
N1 - Score=10
PY - 2016/10/17
Y1 - 2016/10/17
N2 - Traditionally, non-cancer diseases are not considered as health risks following exposure to low doses of ionizing radiation. Indeed, non-cancer diseases are classified as deterministic tissue reactions, which are characterized by a threshold dose. It is judged that below an absorbed dose of 100 mGy, no clinically relevant tissue damage occurs, forming the basis for the current radiation protection system concerning non-cancer effects. Recent epidemiological findings point, however, to an excess risk of non-cancer diseases following exposure to lower doses of ionizing radiation than was previously thought. The evidence is the most sound for cardiovascular disease (CVD) and cataract. Due to limited statistical power, the dose-risk relationship is undetermined below 0.5 Gy; however, if this relationship proves to be without a threshold, it may have considerable impact on current low‑dose health risk estimates. In this review, we describe the CVD risk related to low doses of ionizing radiation, the clinical manifestation and the pathology of radiation-induced CVD, as well as the importance of the endothelium models in CVD research as a way forward to complement the epidemiological data with the underlying biological and molecular mechanisms
AB - Traditionally, non-cancer diseases are not considered as health risks following exposure to low doses of ionizing radiation. Indeed, non-cancer diseases are classified as deterministic tissue reactions, which are characterized by a threshold dose. It is judged that below an absorbed dose of 100 mGy, no clinically relevant tissue damage occurs, forming the basis for the current radiation protection system concerning non-cancer effects. Recent epidemiological findings point, however, to an excess risk of non-cancer diseases following exposure to lower doses of ionizing radiation than was previously thought. The evidence is the most sound for cardiovascular disease (CVD) and cataract. Due to limited statistical power, the dose-risk relationship is undetermined below 0.5 Gy; however, if this relationship proves to be without a threshold, it may have considerable impact on current low‑dose health risk estimates. In this review, we describe the CVD risk related to low doses of ionizing radiation, the clinical manifestation and the pathology of radiation-induced CVD, as well as the importance of the endothelium models in CVD research as a way forward to complement the epidemiological data with the underlying biological and molecular mechanisms
KW - Cardiovascular Disease
KW - Ionizing radiation
KW - Low dose research
KW - Endothelial cells
KW - Radiobiology
UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/20528916
U2 - 10.3892/ijmm.2016.2777
DO - 10.3892/ijmm.2016.2777
M3 - Article
SN - 1107-3756
VL - 38
SP - 1623
EP - 1641
JO - International Journal of Molecular Medicine
JF - International Journal of Molecular Medicine
IS - 6
ER -