Cellular dose-response models for [177Lu]Lu-DOTATyr3, octreotate radionuclide therapy compared to external beam radiotherapy

Giulia Tamborino; Marijke De Saint-Hubert; Lara Struelens; Mark W. Konijnenberg; Marion de Jong; Julie Nonnekens

doi:10.1007/s00259-019-04486-2

Cellular dose-response models for [177Lu]Lu-DOTATyr3, octreotate radionuclide therapy compared to external beam radiotherapy

Giulia Tamborino, Marijke De Saint-Hubert, Lara Struelens, Mark W. Konijnenberg, Marion de Jong, Julie Nonnekens

Research in Dosimetric Applications

Research output › peer-review

Abstract

To investigate the applicability of different dose-response models for in vitro radiobiological experiments with Peptide Receptor Radionuclide Therapy (PRRT) in
comparison to the well-established linear-quadratic (LQ) model.

Original language	English
Title of host publication	Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain
Subtitle of host publication	European Journal of Nuclear Medicine and Molecular Imaging
Place of Publication	Barcelona, Spain
Pages	S86-S87
Number of pages	2
Volume	46
Edition	2019
DOIs	https://doi.org/10.1007/s00259-019-04486-2
State	Published - 14 Sep 2019

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Cite this

Tamborino, G., De Saint-Hubert, M., Struelens, L., Konijnenberg, M. W., de Jong, M., & Nonnekens, J. (2019). Cellular dose-response models for [177Lu]Lu-DOTATyr3, octreotate radionuclide therapy compared to external beam radiotherapy. In Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain: European Journal of Nuclear Medicine and Molecular Imaging (2019 ed., Vol. 46, pp. S86-S87). https://doi.org/10.1007/s00259-019-04486-2

Tamborino, Giulia ; De Saint-Hubert, Marijke ; Struelens, Lara et al. / Cellular dose-response models for [177Lu]Lu-DOTATyr3, octreotate radionuclide therapy compared to external beam radiotherapy. Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain: European Journal of Nuclear Medicine and Molecular Imaging . Vol. 46 2019. ed. Barcelona, Spain, 2019. pp. S86-S87

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title = "Cellular dose-response models for [177Lu]Lu-DOTATyr3, octreotate radionuclide therapy compared to external beam radiotherapy",

abstract = "To investigate the applicability of different dose-response models for in vitro radiobiological experiments with Peptide Receptor Radionuclide Therapy (PRRT) incomparison to the well-established linear-quadratic (LQ) model.",

keywords = "Double strand breaks, Targeted Radionuclide Therapy, Dose-response",

author = "Giulia Tamborino and {De Saint-Hubert}, Marijke and Lara Struelens and Konijnenberg, {Mark W.} and {de Jong}, Marion and Julie Nonnekens",

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Tamborino, G , De Saint-Hubert, M , Struelens, L, Konijnenberg, MW, de Jong, M & Nonnekens, J 2019, Cellular dose-response models for [177Lu]Lu-DOTATyr3, octreotate radionuclide therapy compared to external beam radiotherapy. in Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain: European Journal of Nuclear Medicine and Molecular Imaging . 2019 edn, vol. 46, Barcelona, Spain, pp. S86-S87. https://doi.org/10.1007/s00259-019-04486-2

Cellular dose-response models for [177Lu]Lu-DOTATyr3, octreotate radionuclide therapy compared to external beam radiotherapy. / Tamborino, Giulia ; De Saint-Hubert, Marijke ; Struelens, Lara et al.
Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain: European Journal of Nuclear Medicine and Molecular Imaging . Vol. 46 2019. ed. Barcelona, Spain, 2019. p. S86-S87.

Research output › peer-review

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AU - Konijnenberg, Mark W.

AU - de Jong, Marion

AU - Nonnekens, Julie

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KW - Dose-response

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Tamborino G , De Saint-Hubert M , Struelens L, Konijnenberg MW, de Jong M, Nonnekens J. Cellular dose-response models for [177Lu]Lu-DOTATyr3, octreotate radionuclide therapy compared to external beam radiotherapy. In Annual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain: European Journal of Nuclear Medicine and Molecular Imaging . 2019 ed. Vol. 46. Barcelona, Spain. 2019. p. S86-S87 doi: 10.1007/s00259-019-04486-2