Cellular dosimetry of [177Lu]Lu-DOTA-[Tyr3]octreotate radionuclide therapy: the impact of modeling assumptions on the correlation with in vitro cytotoxicity

Giulia Tamborino, Marijke De Saint-Hubert, Lara Struelens, Dayana C. Seoane, Eline A.M. Ruigrok, An Aerts, Wiggert A. van Cappellen, Marion de Jong, Mark W. Konijnenberg, Julie Nonnekens

Research outputpeer-review

40 Downloads (Pure)

Abstract

Survival and linear-quadratic model fitting parameters implemented in treatment planning for targeted radionuclide therapy depend on accurate cellular dosimetry. Therefore, we have built a refined cellular dosimetry model for [177Lu]Lu-DOTA-[Tyr3]octreotate (177Lu-DOTATATE) in vitro experiments, accounting for specific cell morphologies and sub-cellular radioactivity distributions.
Original languageEnglish
Pages (from-to)1-19
Number of pages19
JournalEJNMMI Physics
Volume7
Issue number8
DOIs
StatePublished - 10 Feb 2020

Cite this