Chapter 35: Molecular Imaging Using Nanobodies: A Case Study

Nick Devoogdt, Catarina Xavier, Sophie Hernot, Ilse Vaneycken, Matthias D'huyvetter, Jens De Vos, Sam Massa, Patrick De Baetselier, Vicky Caveliers, Tony Lahoutte, Nathalie Impens, An Aerts, Sarah Baatout

    Research outputpeer-review


    Molecular imaging is a noninvasive method to measure specific biological processes in animal models and patients using imaging. In recent years there has been a tremendous evolution in hardware and software for imaging purposes. This progress has created an urgent need for new labeled targeted molecular probes. The unique physicochemical and pharmacokinetic properties of Nanobodies match the requirements of the ideal molecular imaging tracer. Preclinical studies show strong and specific targeting in vivo with rapid clearance of unbound probe resulting in high contrasted images at early time points after intravenous administration. These data suggest that the Nanobody platform might become a generic method for the development of next generation molecular imaging probes.
    Original languageEnglish
    Title of host publicationSinge Domain Antibodies, Methods and Protocols
    Place of PublicationSpringer New York Heidelberg Dordrecht London, United States
    ISBN (Print)978-1-61779-968-6
    StatePublished - Jan 2012

    Publication series

    NameMethods in Molecular Biology

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