Chapter 35: Molecular Imaging Using Nanobodies: A Case Study

Nick Devoogdt; Catarina Xavier; Sophie Hernot; Ilse Vaneycken; Matthias D'huyvetter; Jens De Vos; Sam Massa; Patrick De Baetselier; Vicky Caveliers; Tony Lahoutte; Nathalie Impens; An Aerts; Sarah Baatout

Chapter 35: Molecular Imaging Using Nanobodies: A Case Study

Nick Devoogdt, Catarina Xavier, Sophie Hernot, Ilse Vaneycken, Matthias D'huyvetter, Jens De Vos, Sam Massa, Patrick De Baetselier, Vicky Caveliers, Tony Lahoutte, Nathalie Impens, An Aerts, Sarah Baatout

Research output › peer-review

Abstract

Molecular imaging is a noninvasive method to measure specific biological processes in animal models and patients using imaging. In recent years there has been a tremendous evolution in hardware and software for imaging purposes. This progress has created an urgent need for new labeled targeted molecular probes. The unique physicochemical and pharmacokinetic properties of Nanobodies match the requirements of the ideal molecular imaging tracer. Preclinical studies show strong and specific targeting in vivo with rapid clearance of unbound probe resulting in high contrasted images at early time points after intravenous administration. These data suggest that the Nanobody platform might become a generic method for the development of next generation molecular imaging probes.

Original language	English
Title of host publication	Singe Domain Antibodies, Methods and Protocols
Place of Publication	Springer New York Heidelberg Dordrecht London, United States
Publisher	Springer
Pages	559-567
Edition	1
ISBN (Print)	978-1-61779-968-6
State	Published - Jan 2012

Publication series

Name	Methods in Molecular Biology
Number	911

Cite this

Devoogdt, N., Xavier, C., Hernot, S., Vaneycken, I., D'huyvetter, M., De Vos, J., Massa, S., De Baetselier, P., Caveliers, V., Lahoutte, T., Impens, N., Aerts, A., & Baatout, S. (2012). Chapter 35: Molecular Imaging Using Nanobodies: A Case Study. In Singe Domain Antibodies, Methods and Protocols (1 ed., pp. 559-567). (Methods in Molecular Biology; No. 911). Springer.

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abstract = "Molecular imaging is a noninvasive method to measure specific biological processes in animal models and patients using imaging. In recent years there has been a tremendous evolution in hardware and software for imaging purposes. This progress has created an urgent need for new labeled targeted molecular probes. The unique physicochemical and pharmacokinetic properties of Nanobodies match the requirements of the ideal molecular imaging tracer. Preclinical studies show strong and specific targeting in vivo with rapid clearance of unbound probe resulting in high contrasted images at early time points after intravenous administration. These data suggest that the Nanobody platform might become a generic method for the development of next generation molecular imaging probes.",

keywords = "Molecular imaging, Biodistribution, SPECT, PET, Radiochemistry, Radionuclide",

author = "Nick Devoogdt and Catarina Xavier and Sophie Hernot and Ilse Vaneycken and Matthias D'huyvetter and {De Vos}, Jens and Sam Massa and {De Baetselier}, Patrick and Vicky Caveliers and Tony Lahoutte and Nathalie Impens and An Aerts and Sarah Baatout",

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Devoogdt, N, Xavier, C, Hernot, S, Vaneycken, I, D'huyvetter, M, De Vos, J, Massa, S, De Baetselier, P, Caveliers, V, Lahoutte, T, Impens, N, Aerts, A & Baatout, S 2012, Chapter 35: Molecular Imaging Using Nanobodies: A Case Study. in Singe Domain Antibodies, Methods and Protocols. 1 edn, Methods in Molecular Biology, no. 911, Springer, Springer New York Heidelberg Dordrecht London, United States, pp. 559-567.

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AU - D'huyvetter, Matthias

AU - De Vos, Jens

AU - Massa, Sam

AU - De Baetselier, Patrick

AU - Caveliers, Vicky

AU - Lahoutte, Tony

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KW - Biodistribution

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KW - PET

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