Chromosomal abnormalities in lymphocytes from monkeys poisoned with lead

Gh Deknudt; A. Colle; G. B. Gerber

doi:10.1016/0027-5107(77)90045-8

Chromosomal abnormalities in lymphocytes from monkeys poisoned with lead

Gh Deknudt, A. Colle, G. B. Gerber

Research output › peer-review

Abstract

Cynomolgus monkeys (Macaca irus) were given 0, 1.5, 6 or 15 mg of lead acetate 6 days a week for 16 months. Another group, also receiving 6 mg, was kept on a low-calcium diet. Each experimental group consisted of 2 monkeys. Chromosome analysis on cultured lymphocytes was carried out after 3, 10 and 16 months of lead treatment. The frequency of severe abnormalities (dicentrics, rings, translocations and exchanges) was significantly increased only in the group on a low calcium diet, whereas "light" abnormalities (gaps and fragments) increased with time in all groups receiving lead irrespective of the diet. The blood lead data indicate the severity of the lead poisoning.

Original language	English
Pages (from-to)	77-83
Number of pages	7
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	45
Issue number	1
DOIs	https://doi.org/10.1016/0027-5107(77)90045-8
State	Published - Oct 1977
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Health, Toxicology and Mutagenesis

Access to Document

10.1016/0027-5107(77)90045-8

Cite this

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title = "Chromosomal abnormalities in lymphocytes from monkeys poisoned with lead",

abstract = "Cynomolgus monkeys (Macaca irus) were given 0, 1.5, 6 or 15 mg of lead acetate 6 days a week for 16 months. Another group, also receiving 6 mg, was kept on a low-calcium diet. Each experimental group consisted of 2 monkeys. Chromosome analysis on cultured lymphocytes was carried out after 3, 10 and 16 months of lead treatment. The frequency of severe abnormalities (dicentrics, rings, translocations and exchanges) was significantly increased only in the group on a low calcium diet, whereas {"}light{"} abnormalities (gaps and fragments) increased with time in all groups receiving lead irrespective of the diet. The blood lead data indicate the severity of the lead poisoning.",

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AU - Deknudt, Gh

AU - Colle, A.

AU - Gerber, G. B.

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N2 - Cynomolgus monkeys (Macaca irus) were given 0, 1.5, 6 or 15 mg of lead acetate 6 days a week for 16 months. Another group, also receiving 6 mg, was kept on a low-calcium diet. Each experimental group consisted of 2 monkeys. Chromosome analysis on cultured lymphocytes was carried out after 3, 10 and 16 months of lead treatment. The frequency of severe abnormalities (dicentrics, rings, translocations and exchanges) was significantly increased only in the group on a low calcium diet, whereas "light" abnormalities (gaps and fragments) increased with time in all groups receiving lead irrespective of the diet. The blood lead data indicate the severity of the lead poisoning.

AB - Cynomolgus monkeys (Macaca irus) were given 0, 1.5, 6 or 15 mg of lead acetate 6 days a week for 16 months. Another group, also receiving 6 mg, was kept on a low-calcium diet. Each experimental group consisted of 2 monkeys. Chromosome analysis on cultured lymphocytes was carried out after 3, 10 and 16 months of lead treatment. The frequency of severe abnormalities (dicentrics, rings, translocations and exchanges) was significantly increased only in the group on a low calcium diet, whereas "light" abnormalities (gaps and fragments) increased with time in all groups receiving lead irrespective of the diet. The blood lead data indicate the severity of the lead poisoning.

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