Chromosomal damage induced in human lymphocytes by low doses of D-T neutrons

Johanna Pohl-Rüling; Patricia E. Fischer; David C. Lloyd; Alan A. Edwards; Adayapalam Tyagarajan Natarajan; Guenter Obe; Karin E. Buckton; Néstor Oscar Bianchi; Paul P.W. van Buul; B. C. Das; Franz Daschil; Luc Fabry; Maria Kučerová; Alain Y. Léonard; R. N. Mukherjee; U. Mukherjee; Robert Nowotny; P. Palitti; Zdeňka Polívková; Tikaram R. Sharma; W. Schmidt

doi:10.1016/0165-7992(86)90022-9

Chromosomal damage induced in human lymphocytes by low doses of D-T neutrons

Johanna Pohl-Rüling, Patricia E. Fischer, David C. Lloyd, Alan A. Edwards, Adayapalam Tyagarajan Natarajan, Guenter Obe, Karin E. Buckton, Néstor Oscar Bianchi, Paul P.W. van Buul, B. C. Das, Franz Daschil, Luc Fabry, Maria Kučerová, Alain Y. Léonard, R. N. Mukherjee, U. Mukherjee, Robert Nowotny, P. Palitti, Zdeňka Polívková, Tikaram R. SharmaW. Schmidt

Research output › peer-review

Abstract

Unstable chromosome aberrations induced by in vitro irradiation with zero plus seven low doses of 14.8 MeV D-T neutrons in the range 3.55-244 mGy have been analysed in human peripheral blood lymphocytes. In order to obtain the required large numbers of scored cells for such low doses, fourteen laboratories participated in the experiment. The dose responses for dicentrics, excess acentrics and total aberrations, fitted well to the Y = αD model. The α coefficient of yield for dicentrics, 1.60 ± 0.07 × 10^-2 Gy^-1, compares well with the values obtained in previous studies with D-T neutrons at somewhat higher doses. Results from a previous collaborative study using 250 kVp X-rays over a comparable dose range indicated the possible existence of a threshold below 50 mGy. In the present study there is no clear evidence for neutrons for such a threshold. However, the data were insufficient to permit the rejection of a possible threshold below ∼ 10 mGy.

Original language	English
Pages (from-to)	267-272
Number of pages	6
Journal	Mutation Research Letters
Volume	173
Issue number	4
DOIs	https://doi.org/10.1016/0165-7992(86)90022-9
State	Published - Apr 1986

Funding

In a co-ordinated research programme sponsored by the International Atomic Energy Agency (IAEA) the effect of low doses of acute X-

Funders	Funder number
International Atomic Energy Agency (IAEA)

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/0165-7992(86)90022-9

Cite this

Pohl-Rüling, J., Fischer, P. E., Lloyd, D. C., Edwards, A. A., Natarajan, A. T., Obe, G., Buckton, K. E., Bianchi, N. O., van Buul, P. P. W., Das, B. C., Daschil, F., Fabry, L., Kučerová, M., Léonard, A. Y., Mukherjee, R. N., Mukherjee, U., Nowotny, R., Palitti, P., Polívková, Z., ... Schmidt, W. (1986). Chromosomal damage induced in human lymphocytes by low doses of D-T neutrons. Mutation Research Letters, 173(4), 267-272. https://doi.org/10.1016/0165-7992(86)90022-9

@article{702f87d0f07a41d79254616f843ae426,

title = "Chromosomal damage induced in human lymphocytes by low doses of D-T neutrons",

abstract = "Unstable chromosome aberrations induced by in vitro irradiation with zero plus seven low doses of 14.8 MeV D-T neutrons in the range 3.55-244 mGy have been analysed in human peripheral blood lymphocytes. In order to obtain the required large numbers of scored cells for such low doses, fourteen laboratories participated in the experiment. The dose responses for dicentrics, excess acentrics and total aberrations, fitted well to the Y = αD model. The α coefficient of yield for dicentrics, 1.60 ± 0.07 × 10-2 Gy-1, compares well with the values obtained in previous studies with D-T neutrons at somewhat higher doses. Results from a previous collaborative study using 250 kVp X-rays over a comparable dose range indicated the possible existence of a threshold below 50 mGy. In the present study there is no clear evidence for neutrons for such a threshold. However, the data were insufficient to permit the rejection of a possible threshold below ∼ 10 mGy.",

author = "Johanna Pohl-R{\"u}ling and Fischer, {Patricia E.} and Lloyd, {David C.} and Edwards, {Alan A.} and Natarajan, {Adayapalam Tyagarajan} and Guenter Obe and Buckton, {Karin E.} and Bianchi, {N{\'e}stor Oscar} and {van Buul}, {Paul P.W.} and Das, {B. C.} and Franz Daschil and Luc Fabry and Maria Ku{\v c}erov{\'a} and L{\'e}onard, {Alain Y.} and Mukherjee, {R. N.} and U. Mukherjee and Robert Nowotny and P. Palitti and Zde{\v n}ka Pol{\'i}vkov{\'a} and Sharma, {Tikaram R.} and W. Schmidt",

year = "1986",

month = apr,

doi = "10.1016/0165-7992(86)90022-9",

language = "English",

volume = "173",

pages = "267--272",

journal = "Mutation Research Letters",

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Pohl-Rüling, J, Fischer, PE, Lloyd, DC, Edwards, AA, Natarajan, AT, Obe, G, Buckton, KE, Bianchi, NO, van Buul, PPW, Das, BC, Daschil, F, Fabry, L, Kučerová, M, Léonard, AY, Mukherjee, RN, Mukherjee, U, Nowotny, R, Palitti, P, Polívková, Z, Sharma, TR & Schmidt, W 1986, 'Chromosomal damage induced in human lymphocytes by low doses of D-T neutrons', Mutation Research Letters, vol. 173, no. 4, pp. 267-272. https://doi.org/10.1016/0165-7992(86)90022-9

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T1 - Chromosomal damage induced in human lymphocytes by low doses of D-T neutrons

AU - Pohl-Rüling, Johanna

AU - Fischer, Patricia E.

AU - Lloyd, David C.

AU - Edwards, Alan A.

AU - Natarajan, Adayapalam Tyagarajan

AU - Obe, Guenter

AU - Buckton, Karin E.

AU - Bianchi, Néstor Oscar

AU - van Buul, Paul P.W.

AU - Das, B. C.

AU - Daschil, Franz

AU - Fabry, Luc

AU - Kučerová, Maria

AU - Léonard, Alain Y.

AU - Mukherjee, R. N.

AU - Mukherjee, U.

AU - Nowotny, Robert

AU - Palitti, P.

AU - Polívková, Zdeňka

AU - Sharma, Tikaram R.

AU - Schmidt, W.

PY - 1986/4

Y1 - 1986/4

N2 - Unstable chromosome aberrations induced by in vitro irradiation with zero plus seven low doses of 14.8 MeV D-T neutrons in the range 3.55-244 mGy have been analysed in human peripheral blood lymphocytes. In order to obtain the required large numbers of scored cells for such low doses, fourteen laboratories participated in the experiment. The dose responses for dicentrics, excess acentrics and total aberrations, fitted well to the Y = αD model. The α coefficient of yield for dicentrics, 1.60 ± 0.07 × 10-2 Gy-1, compares well with the values obtained in previous studies with D-T neutrons at somewhat higher doses. Results from a previous collaborative study using 250 kVp X-rays over a comparable dose range indicated the possible existence of a threshold below 50 mGy. In the present study there is no clear evidence for neutrons for such a threshold. However, the data were insufficient to permit the rejection of a possible threshold below ∼ 10 mGy.

AB - Unstable chromosome aberrations induced by in vitro irradiation with zero plus seven low doses of 14.8 MeV D-T neutrons in the range 3.55-244 mGy have been analysed in human peripheral blood lymphocytes. In order to obtain the required large numbers of scored cells for such low doses, fourteen laboratories participated in the experiment. The dose responses for dicentrics, excess acentrics and total aberrations, fitted well to the Y = αD model. The α coefficient of yield for dicentrics, 1.60 ± 0.07 × 10-2 Gy-1, compares well with the values obtained in previous studies with D-T neutrons at somewhat higher doses. Results from a previous collaborative study using 250 kVp X-rays over a comparable dose range indicated the possible existence of a threshold below 50 mGy. In the present study there is no clear evidence for neutrons for such a threshold. However, the data were insufficient to permit the rejection of a possible threshold below ∼ 10 mGy.

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