Conformal flash pt nozzle prototype: a secondary neutron dose assessment

Andrea Matamoros Ortega; Dries Colson; Jana Hohmann; Valentin Hamaide; Marijke De Saint-Hubert; Olivier Van Hoey; Tom Depuydt

doi:10.1016/j.ijpt.2024.100523

Conformal flash pt nozzle prototype: a secondary neutron dose assessment

Andrea Matamoros Ortega, Dries Colson, Jana Hohmann, Valentin Hamaide, Marijke De Saint-Hubert, Olivier Van Hoey, Tom Depuydt

Research output › peer-review

Abstract

FLASH proton therapy (PT) delivers high radiation doses to the tumor at an extremely fast dose rate. Due to the beam energy switching time, only one fixed energy can be used. To achieve a dose distribution conformal to the target volume, three patient-specific accessories need to be inserted into the PT system’s snout: a 3D range modulator (3DRM), a range shifter and an aperture block. It is expected that the presence of these devices in the beamline will result in increased out-of-field neutron doses in the patient. This work quantifies this effect for the first time with Monte Carlo simulations for the compact IBA Proteus ONE system and compares it to conventional intensity- modulated PT delivery (IMPT).

Original language	English
Title of host publication	International Journal of Particle Therapy
Subtitle of host publication	Proceedings to the 62nd Annual Conference of the Particle Therapy Cooperative Group (PTCOG)
Publisher	Elsevier
Chapter	Supplement
Pages	138
Number of pages	1
Volume	12
DOIs	https://doi.org/10.1016/j.ijpt.2024.100523
State	Published - Jun 2024
Event	2024 - PTCOG: 62nd annual PTCOG conference & 4th PTCOG-AO meeting - Duration: 10 Jun 2024 → 15 Jun 2024 Conference number: PTCOG62

Publication series

Name	International Journal of Particle Therapy
Publisher	Elsevier
Volume	12
ISSN (Electronic)	2331-5180

Conference

Conference	2024 - PTCOG
Country/Territory	Singapore
Period	2024-06-10 → 2024-06-15

Access to Document

10.1016/j.ijpt.2024.100523License:

Cite this

Matamoros Ortega, A., Colson, D., Hohmann, J., Hamaide, V., De Saint-Hubert, M., Van Hoey, O., & Depuydt, T. (2024). Conformal flash pt nozzle prototype: a secondary neutron dose assessment. In International Journal of Particle Therapy: Proceedings to the 62nd Annual Conference of the Particle Therapy Cooperative Group (PTCOG) (Vol. 12, pp. 138). Article 100523 (International Journal of Particle Therapy; Vol. 12). Elsevier. https://doi.org/10.1016/j.ijpt.2024.100523

@inproceedings{b53262ebb3334bc3bb6bbf3876531b9a,

title = "Conformal flash pt nozzle prototype: a secondary neutron dose assessment",

abstract = "FLASH proton therapy (PT) delivers high radiation doses to the tumor at an extremely fast dose rate. Due to the beam energy switching time, only one fixed energy can be used. To achieve a dose distribution conformal to the target volume, three patient-specific accessories need to be inserted into the PT system{\textquoteright}s snout: a 3D range modulator (3DRM), a range shifter and an aperture block. It is expected that the presence of these devices in the beamline will result in increased out-of-field neutron doses in the patient. This work quantifies this effect for the first time with Monte Carlo simulations for the compact IBA Proteus ONE system and compares it to conventional intensity- modulated PT delivery (IMPT).",

keywords = "Conformal FLASH proton therapy, Out-of-field dose, Monte Carlo, TOPAS, OpenTPS",

author = "{Matamoros Ortega}, Andrea and Dries Colson and Jana Hohmann and Valentin Hamaide and {De Saint-Hubert}, Marijke and {Van Hoey}, Olivier and Tom Depuydt",

note = "Score=3; 2024 - PTCOG : 62nd annual PTCOG conference & 4th PTCOG-AO meeting ; Conference date: 10-06-2024 Through 15-06-2024",

year = "2024",

month = jun,

doi = "10.1016/j.ijpt.2024.100523",

language = "English",

volume = "12",

series = "International Journal of Particle Therapy",

publisher = "Elsevier",

pages = "138",

booktitle = "International Journal of Particle Therapy",

address = "Netherlands",

}

Matamoros Ortega, A, Colson, D, Hohmann, J, Hamaide, V, De Saint-Hubert, M , Van Hoey, O & Depuydt, T 2024, Conformal flash pt nozzle prototype: a secondary neutron dose assessment. in International Journal of Particle Therapy: Proceedings to the 62nd Annual Conference of the Particle Therapy Cooperative Group (PTCOG). vol. 12, 100523, International Journal of Particle Therapy, vol. 12, Elsevier, pp. 138, 2024 - PTCOG, Singapore, 2024-06-10. https://doi.org/10.1016/j.ijpt.2024.100523

Conformal flash pt nozzle prototype: a secondary neutron dose assessment. / Matamoros Ortega, Andrea; Colson, Dries; Hohmann, Jana et al.
International Journal of Particle Therapy: Proceedings to the 62nd Annual Conference of the Particle Therapy Cooperative Group (PTCOG). Vol. 12 Elsevier, 2024. p. 138 100523 (International Journal of Particle Therapy; Vol. 12).

Research output › peer-review

TY - GEN

T1 - Conformal flash pt nozzle prototype

T2 - 2024 - PTCOG

AU - Matamoros Ortega, Andrea

AU - Colson, Dries

AU - Hohmann, Jana

AU - Hamaide, Valentin

AU - De Saint-Hubert, Marijke

AU - Van Hoey, Olivier

AU - Depuydt, Tom

N1 - Conference code: PTCOG62

PY - 2024/6

Y1 - 2024/6

N2 - FLASH proton therapy (PT) delivers high radiation doses to the tumor at an extremely fast dose rate. Due to the beam energy switching time, only one fixed energy can be used. To achieve a dose distribution conformal to the target volume, three patient-specific accessories need to be inserted into the PT system’s snout: a 3D range modulator (3DRM), a range shifter and an aperture block. It is expected that the presence of these devices in the beamline will result in increased out-of-field neutron doses in the patient. This work quantifies this effect for the first time with Monte Carlo simulations for the compact IBA Proteus ONE system and compares it to conventional intensity- modulated PT delivery (IMPT).

AB - FLASH proton therapy (PT) delivers high radiation doses to the tumor at an extremely fast dose rate. Due to the beam energy switching time, only one fixed energy can be used. To achieve a dose distribution conformal to the target volume, three patient-specific accessories need to be inserted into the PT system’s snout: a 3D range modulator (3DRM), a range shifter and an aperture block. It is expected that the presence of these devices in the beamline will result in increased out-of-field neutron doses in the patient. This work quantifies this effect for the first time with Monte Carlo simulations for the compact IBA Proteus ONE system and compares it to conventional intensity- modulated PT delivery (IMPT).

KW - Conformal FLASH proton therapy

KW - Out-of-field dose

KW - Monte Carlo

KW - TOPAS

KW - OpenTPS

U2 - 10.1016/j.ijpt.2024.100523

DO - 10.1016/j.ijpt.2024.100523

M3 - In-proceedings paper

VL - 12

T3 - International Journal of Particle Therapy

SP - 138

BT - International Journal of Particle Therapy

PB - Elsevier

Y2 - 10 June 2024 through 15 June 2024

ER -

Matamoros Ortega A, Colson D, Hohmann J, Hamaide V, De Saint-Hubert M , Van Hoey O et al. Conformal flash pt nozzle prototype: a secondary neutron dose assessment. In International Journal of Particle Therapy: Proceedings to the 62nd Annual Conference of the Particle Therapy Cooperative Group (PTCOG). Vol. 12. Elsevier. 2024. p. 138. 100523. (International Journal of Particle Therapy). doi: 10.1016/j.ijpt.2024.100523