Convergence and divergence between the transcriptional responses to Zika virus infection and prenatal irradiation

Roel Quintens

doi:10.1038/cddis.2017.109

Convergence and divergence between the transcriptional responses to Zika virus infection and prenatal irradiation

Research output › peer-review

Abstract

In a recent paper in Cell Death and Disease, Di Cunto and co-workers found that infection of human neural progenitors (hNPCs) with Zika virus (ZIKV) induced transcriptional responses that were partly comparable to three different genetic mutations (CitK− /−, Magoh+/ −, and conditional Elp3−/− mice), which result in microcephaly in mice. The highest overlap between these different conditions was found in the activation of P53 target genes.

Original language	English
Article number	E2672
Pages (from-to)	1-3
Number of pages	3
Journal	Cell Death and Disease
Volume	8
DOIs	https://doi.org/10.1038/cddis.2017.109
State	Published - 16 Mar 2017

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abstract = "In a recent paper in Cell Death and Disease, Di Cunto and co-workers found that infection of human neural progenitors (hNPCs) with Zika virus (ZIKV) induced transcriptional responses that were partly comparable to three different genetic mutations (CitK− /−, Magoh+/ −, and conditional Elp3−/− mice), which result in microcephaly in mice. The highest overlap between these different conditions was found in the activation of P53 target genes.",

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