Critical evaluation of the chemical standardization procedure for measuring gastric emptying of solids

P. Goethals; A. Volkaert; Bruno A. van Vlem; Raymond Camille Vanholder

doi:10.1002/jlcr.609

Critical evaluation of the chemical standardization procedure for measuring gastric emptying of solids

P. Goethals, A. Volkaert, Bruno A. van Vlem, Raymond Camille Vanholder

Research output › peer-review

Abstract

The purpose of this study was to evaluate the baking process of yolk spiked with octanoate to measure gastric emptying rate of solids. [1-¹¹C]octanoate was produced by the reaction of [¹¹C]CO₂ with heptyl magnesium bromide in tetrahydrofuran (THF), followed by purification with HPLC. The decay corrected radiochemical yield ranged from 24 to 38% (5.9-9.8 GBq EOS, synthesis time: 25 min; specific radioactivity ∼90 GBq μmol^-1). To check the evaporation of [1-¹¹C]octanoate during the baking process of yolk, [1-¹¹C]octanoate or potassium [1-¹¹C]octanoate, respectively, was added. An important fraction of the acid evaporated while for the potassium [1-¹¹C]octanoate < 10% disappeared. Conclusion: potassium (1-¹³C)octanoate is a better tracer than (1-¹³C) octanoate to study gastroenterological phenomena.

Original language	English
Pages (from-to)	1091-1096
Number of pages	6
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	45
Issue number	13
DOIs	https://doi.org/10.1002/jlcr.609
State	Published - Nov 2002

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

Access to Document

10.1002/jlcr.609

Cite this

@article{9960292d074c48f7b026422dd39d6676,

title = "Critical evaluation of the chemical standardization procedure for measuring gastric emptying of solids",

abstract = "The purpose of this study was to evaluate the baking process of yolk spiked with octanoate to measure gastric emptying rate of solids. [1-11C]octanoate was produced by the reaction of [11C]CO2 with heptyl magnesium bromide in tetrahydrofuran (THF), followed by purification with HPLC. The decay corrected radiochemical yield ranged from 24 to 38% (5.9-9.8 GBq EOS, synthesis time: 25 min; specific radioactivity ∼90 GBq μmol-1). To check the evaporation of [1-11C]octanoate during the baking process of yolk, [1-11C]octanoate or potassium [1-11C]octanoate, respectively, was added. An important fraction of the acid evaporated while for the potassium [1-11C]octanoate < 10% disappeared. Conclusion: potassium (1-13C)octanoate is a better tracer than (1-13C) octanoate to study gastroenterological phenomena.",

keywords = "Gastric emptying, PET, [1-C]octanoate",

author = "P. Goethals and A. Volkaert and {van Vlem}, {Bruno A.} and Vanholder, {Raymond Camille}",

year = "2002",

month = nov,

doi = "10.1002/jlcr.609",

language = "English",

volume = "45",

pages = "1091--1096",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

publisher = "Wiley - John Wiley & Sons, Ltd",

number = "13",

}

TY - JOUR

T1 - Critical evaluation of the chemical standardization procedure for measuring gastric emptying of solids

AU - Goethals, P.

AU - Volkaert, A.

AU - van Vlem, Bruno A.

AU - Vanholder, Raymond Camille

PY - 2002/11

Y1 - 2002/11

N2 - The purpose of this study was to evaluate the baking process of yolk spiked with octanoate to measure gastric emptying rate of solids. [1-11C]octanoate was produced by the reaction of [11C]CO2 with heptyl magnesium bromide in tetrahydrofuran (THF), followed by purification with HPLC. The decay corrected radiochemical yield ranged from 24 to 38% (5.9-9.8 GBq EOS, synthesis time: 25 min; specific radioactivity ∼90 GBq μmol-1). To check the evaporation of [1-11C]octanoate during the baking process of yolk, [1-11C]octanoate or potassium [1-11C]octanoate, respectively, was added. An important fraction of the acid evaporated while for the potassium [1-11C]octanoate < 10% disappeared. Conclusion: potassium (1-13C)octanoate is a better tracer than (1-13C) octanoate to study gastroenterological phenomena.

AB - The purpose of this study was to evaluate the baking process of yolk spiked with octanoate to measure gastric emptying rate of solids. [1-11C]octanoate was produced by the reaction of [11C]CO2 with heptyl magnesium bromide in tetrahydrofuran (THF), followed by purification with HPLC. The decay corrected radiochemical yield ranged from 24 to 38% (5.9-9.8 GBq EOS, synthesis time: 25 min; specific radioactivity ∼90 GBq μmol-1). To check the evaporation of [1-11C]octanoate during the baking process of yolk, [1-11C]octanoate or potassium [1-11C]octanoate, respectively, was added. An important fraction of the acid evaporated while for the potassium [1-11C]octanoate < 10% disappeared. Conclusion: potassium (1-13C)octanoate is a better tracer than (1-13C) octanoate to study gastroenterological phenomena.

KW - Gastric emptying

KW - PET

KW - [1-C]octanoate

UR - http://www.scopus.com/inward/record.url?scp=0036856713&partnerID=8YFLogxK

U2 - 10.1002/jlcr.609

DO - 10.1002/jlcr.609

M3 - Article

AN - SCOPUS:0036856713

SN - 0362-4803

VL - 45

SP - 1091

EP - 1096

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 13

ER -