Cytogenetic effects of myleran in vivo on bone-marrow cells from male mice

A. Léonard; E. D. Léonard

doi:10.1016/0027-5107(78)90201-4

Cytogenetic effects of myleran in vivo on bone-marrow cells from male mice

A. Léonard, E. D. Léonard

Research output › peer-review

Abstract

The cytogenetic effects of Myleran were examined in bone-marrow cells from male mice. To study the dose-response relationship the male mice were injected with 5, 10, 20 or 40 mg of Myleran/kg. Bone-marrow samples were prepared 24 h later. The time response was investigated by examining bone-marrow samples 1, 2, 4 or 10 days after i.p. injection of 40 mg of Myleran. Most of the structural aberrations were of the chromatid type and the dose-response relationship was linear. The chromatid and chromosomal aberrations were maximal at 2 days and decreased sharply after longer intervals of time.

Original language	English
Pages (from-to)	329-333
Number of pages	5
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	56
Issue number	3
DOIs	https://doi.org/10.1016/0027-5107(78)90201-4
State	Published - Jan 1978

ASJC Scopus subject areas

Molecular Biology
Genetics
Health, Toxicology and Mutagenesis

Access to Document

10.1016/0027-5107(78)90201-4

Cite this

@article{0b01ba8637ee4e519ae6a63dd3a042c2,

title = "Cytogenetic effects of myleran in vivo on bone-marrow cells from male mice",

abstract = "The cytogenetic effects of Myleran were examined in bone-marrow cells from male mice. To study the dose-response relationship the male mice were injected with 5, 10, 20 or 40 mg of Myleran/kg. Bone-marrow samples were prepared 24 h later. The time response was investigated by examining bone-marrow samples 1, 2, 4 or 10 days after i.p. injection of 40 mg of Myleran. Most of the structural aberrations were of the chromatid type and the dose-response relationship was linear. The chromatid and chromosomal aberrations were maximal at 2 days and decreased sharply after longer intervals of time.",

author = "A. L{\'e}onard and L{\'e}onard, {E. D.}",

year = "1978",

month = jan,

doi = "10.1016/0027-5107(78)90201-4",

language = "English",

volume = "56",

pages = "329--333",

journal = "Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis",

issn = "0027-5107",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Cytogenetic effects of myleran in vivo on bone-marrow cells from male mice

AU - Léonard, A.

AU - Léonard, E. D.

PY - 1978/1

Y1 - 1978/1

N2 - The cytogenetic effects of Myleran were examined in bone-marrow cells from male mice. To study the dose-response relationship the male mice were injected with 5, 10, 20 or 40 mg of Myleran/kg. Bone-marrow samples were prepared 24 h later. The time response was investigated by examining bone-marrow samples 1, 2, 4 or 10 days after i.p. injection of 40 mg of Myleran. Most of the structural aberrations were of the chromatid type and the dose-response relationship was linear. The chromatid and chromosomal aberrations were maximal at 2 days and decreased sharply after longer intervals of time.

AB - The cytogenetic effects of Myleran were examined in bone-marrow cells from male mice. To study the dose-response relationship the male mice were injected with 5, 10, 20 or 40 mg of Myleran/kg. Bone-marrow samples were prepared 24 h later. The time response was investigated by examining bone-marrow samples 1, 2, 4 or 10 days after i.p. injection of 40 mg of Myleran. Most of the structural aberrations were of the chromatid type and the dose-response relationship was linear. The chromatid and chromosomal aberrations were maximal at 2 days and decreased sharply after longer intervals of time.

UR - http://www.scopus.com/inward/record.url?scp=0017880643&partnerID=8YFLogxK

U2 - 10.1016/0027-5107(78)90201-4

DO - 10.1016/0027-5107(78)90201-4

M3 - Article

C2 - 625305

AN - SCOPUS:0017880643

SN - 0027-5107

VL - 56

SP - 329

EP - 333

JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

IS - 3

ER -