Cytogenetic effects of myleran in vivo on bone-marrow cells from male mice

A. Léonard; E. D. Léonard

doi:10.1016/0027-5107(78)90201-4

Cytogenetic effects of myleran in vivo on bone-marrow cells from male mice

A. Léonard, E. D. Léonard

Research output › peer-review

Abstract

The cytogenetic effects of Myleran were examined in bone-marrow cells from male mice. To study the dose-response relationship the male mice were injected with 5, 10, 20 or 40 mg of Myleran/kg. Bone-marrow samples were prepared 24 h later. The time response was investigated by examining bone-marrow samples 1, 2, 4 or 10 days after i.p. injection of 40 mg of Myleran. Most of the structural aberrations were of the chromatid type and the dose-response relationship was linear. The chromatid and chromosomal aberrations were maximal at 2 days and decreased sharply after longer intervals of time.

Original language	English
Pages (from-to)	329-333
Number of pages	5
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	56
Issue number	3
DOIs	https://doi.org/10.1016/0027-5107(78)90201-4
State	Published - Jan 1978

ASJC Scopus subject areas

Molecular Biology
Genetics
Health, Toxicology and Mutagenesis

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10.1016/0027-5107(78)90201-4

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title = "Cytogenetic effects of myleran in vivo on bone-marrow cells from male mice",

abstract = "The cytogenetic effects of Myleran were examined in bone-marrow cells from male mice. To study the dose-response relationship the male mice were injected with 5, 10, 20 or 40 mg of Myleran/kg. Bone-marrow samples were prepared 24 h later. The time response was investigated by examining bone-marrow samples 1, 2, 4 or 10 days after i.p. injection of 40 mg of Myleran. Most of the structural aberrations were of the chromatid type and the dose-response relationship was linear. The chromatid and chromosomal aberrations were maximal at 2 days and decreased sharply after longer intervals of time.",

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year = "1978",

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AU - Léonard, A.

AU - Léonard, E. D.

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N2 - The cytogenetic effects of Myleran were examined in bone-marrow cells from male mice. To study the dose-response relationship the male mice were injected with 5, 10, 20 or 40 mg of Myleran/kg. Bone-marrow samples were prepared 24 h later. The time response was investigated by examining bone-marrow samples 1, 2, 4 or 10 days after i.p. injection of 40 mg of Myleran. Most of the structural aberrations were of the chromatid type and the dose-response relationship was linear. The chromatid and chromosomal aberrations were maximal at 2 days and decreased sharply after longer intervals of time.

AB - The cytogenetic effects of Myleran were examined in bone-marrow cells from male mice. To study the dose-response relationship the male mice were injected with 5, 10, 20 or 40 mg of Myleran/kg. Bone-marrow samples were prepared 24 h later. The time response was investigated by examining bone-marrow samples 1, 2, 4 or 10 days after i.p. injection of 40 mg of Myleran. Most of the structural aberrations were of the chromatid type and the dose-response relationship was linear. The chromatid and chromosomal aberrations were maximal at 2 days and decreased sharply after longer intervals of time.

UR - https://www.scopus.com/pages/publications/0017880643

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