@inproceedings{0147315d43274938bddcf5ad5c636463,
title = "Development of an in-house 188W/188Re generator for rhenium-188 production and radiolabelling studies",
abstract = "Rhenium is a fascinating metal with a rich coordination chemistry and its isotopes have shown great potential for use in radiotherapy. The isotope 188Re is particularly interesting as it emits high-energy beta particles (Emax = 2.12 MeV), making it perfect for radiotherapy of large tumours. The short half-life (t1/2 = 16.9 h) of rhenium-188 also allows it to be used in targeted radionuclide therapy when linked to peptides or antibodies. Additionally, rhenium-188 also decays with a 155 keV (15%) gamma emission suitable for imaging and dosimetry, making it rhenium-188 an ideal theranostic agent in clinical nuclear medicine. Rhenium-188 is readily available from a 188W/188Re generator, which enables the use of non-carrier added (nca) rhenium- 188 in hospitals and remote locations. In light of the recent shortage of 188W/188Re generators on the market, we undertook efforts to prepare our own generator to provide a constant rhenium-188 supply for our research into 188Re-based radiopharmaceuticals. Here we present the in-house development of the 188W/188Re generator and the first applications of this rhenium-188 in the development of novel 188Re-chelators.",
keywords = "Rhenium-188, Radiopharmaceutical, Radiolabelling",
author = "Diana Melis and Tomas Opsomer and Bernard Ponsard and Andrew Burgoyne and Gilles Gasser and {Van de Voorde}, Michiel and Maarten Ooms",
note = "Score=3; 2022 - TERACHEM : The Fourth International Symposium on Technetium and Other Radiometals in Chemistry and Medicine ; Conference date: 14-09-2022 Through 17-09-2022",
year = "2022",
month = dec,
doi = "10.1016/S0969-8051(22)02165-5",
language = "English",
volume = "114-115/S",
series = "Nuclear Medicine and Biology",
publisher = "Elsevier",
pages = "S38",
booktitle = "Nuclear Medicine and Biology",
address = "Netherlands",
}