Development of dendritic spines in the cerebral cortex of the micrencephalic rat following prenatal X-irradiation

I. Ferrer; E. Soriano; E. Martí; E. Digón; H. Reyners; E. Gianfelici de Reyners

doi:10.1016/0304-3940(91)90023-M

Development of dendritic spines in the cerebral cortex of the micrencephalic rat following prenatal X-irradiation

I. Ferrer, E. Soriano, E. Martí, E. Digón, H. Reyners, E. Gianfelici de Reyners

Research output › peer-review

Abstract

Postnatal development of dendritic spines (DS) on the 500-μm-proximal region of the apical dendrite of large layer V pyramidal neurons of the somatosensory cortex (Par 1) was studied with the rapid Golgi method in micrencephalic rats produced after exposure to 100 cGy X-irradiation at embryonic day 18. Treated rats examined at the age of 15 days had more DS than age-matched controls, whereas the reverse occurred in rats aged 30 days. After this time the number of DS decreased in normal rats. As a result, irradiated and control rats aged 90 days had about the same number of DS in the proximal region of the apical dendrite. These results suggest that development of DS appears early, and that natural overproduction and elimination of DS is impaired in the cerebral cortex of micrencephalic rats.

Original language	English
Pages (from-to)	183-186
Number of pages	4
Journal	Neuroscience Letters
Volume	125
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(91)90023-M
State	Published - 29 Apr 1991

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/0304-3940(91)90023-M

Cite this

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title = "Development of dendritic spines in the cerebral cortex of the micrencephalic rat following prenatal X-irradiation",

abstract = "Postnatal development of dendritic spines (DS) on the 500-μm-proximal region of the apical dendrite of large layer V pyramidal neurons of the somatosensory cortex (Par 1) was studied with the rapid Golgi method in micrencephalic rats produced after exposure to 100 cGy X-irradiation at embryonic day 18. Treated rats examined at the age of 15 days had more DS than age-matched controls, whereas the reverse occurred in rats aged 30 days. After this time the number of DS decreased in normal rats. As a result, irradiated and control rats aged 90 days had about the same number of DS in the proximal region of the apical dendrite. These results suggest that development of DS appears early, and that natural overproduction and elimination of DS is impaired in the cerebral cortex of micrencephalic rats.",

keywords = "Dendritic spine development, Spine overproduction and elimination, X-irradiation",

author = "I. Ferrer and E. Soriano and E. Mart{\'i} and E. Dig{\'o}n and H. Reyners and {de Reyners}, {E. Gianfelici}",

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T1 - Development of dendritic spines in the cerebral cortex of the micrencephalic rat following prenatal X-irradiation

AU - Ferrer, I.

AU - Soriano, E.

AU - Martí, E.

AU - Digón, E.

AU - Reyners, H.

AU - de Reyners, E. Gianfelici

PY - 1991/4/29

Y1 - 1991/4/29

N2 - Postnatal development of dendritic spines (DS) on the 500-μm-proximal region of the apical dendrite of large layer V pyramidal neurons of the somatosensory cortex (Par 1) was studied with the rapid Golgi method in micrencephalic rats produced after exposure to 100 cGy X-irradiation at embryonic day 18. Treated rats examined at the age of 15 days had more DS than age-matched controls, whereas the reverse occurred in rats aged 30 days. After this time the number of DS decreased in normal rats. As a result, irradiated and control rats aged 90 days had about the same number of DS in the proximal region of the apical dendrite. These results suggest that development of DS appears early, and that natural overproduction and elimination of DS is impaired in the cerebral cortex of micrencephalic rats.

AB - Postnatal development of dendritic spines (DS) on the 500-μm-proximal region of the apical dendrite of large layer V pyramidal neurons of the somatosensory cortex (Par 1) was studied with the rapid Golgi method in micrencephalic rats produced after exposure to 100 cGy X-irradiation at embryonic day 18. Treated rats examined at the age of 15 days had more DS than age-matched controls, whereas the reverse occurred in rats aged 30 days. After this time the number of DS decreased in normal rats. As a result, irradiated and control rats aged 90 days had about the same number of DS in the proximal region of the apical dendrite. These results suggest that development of DS appears early, and that natural overproduction and elimination of DS is impaired in the cerebral cortex of micrencephalic rats.

KW - Dendritic spine development

KW - Spine overproduction and elimination

KW - X-irradiation

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