Development of mouse kidney models on a nephron scale and influence of non-uniform activity distribution on preclinical renal dosimetry

Michelle Andersson; Nicolas Goudin; Marco Pontoglio; Hugo Levillain; Nick Reynaert; Clarita Saldarriaga Vargas

Development of mouse kidney models on a nephron scale and influence of non-uniform activity distribution on preclinical renal dosimetry

Michelle Andersson, Nicolas Goudin, Marco Pontoglio, Hugo Levillain, Nick Reynaert, Clarita Saldarriaga Vargas

Research output › peer-review

Abstract

Nephrotoxicity is often the dose-limiting factor in Targeted Radionuclide Therapy (TRT) due to the clearance of radiopharmaceuticals through the kidneys. Small radiolabeled peptides are often reabsorbed in the proximal tubules (PT), leading to a heterogeneous dose distribution in nephrons and even within nephron sub-compartments (Glomerulus (GL) , PT, Distal Tubule and Loop of Henle) [1]. In order to investigate factors affecting nephrotoxicity in a controlled manner, preclinical investigations are of great importance. This study investigated the influence of nephron type and morphology on murine nephron dosimetry, as well as the effect of heterogeneous activity distribution in nephrons on kidney tissue dosimetry by developing a 3D multi-nephron anatomical model for dosimetric calculations.

Original language	English
Title of host publication	Meeting ReportMolecular Targeting Probes-Radioactive & Nonradioactive - Dosimetry & Image Analysis
Publisher	SNMMI - Society of Nuclear Medicine and Molecular Imaging
Number of pages	1
State	Published - Jun 2024

Publication series

Name	The journal of nuclear medicine
Publisher	SNMMI
Number	Supplement 2
Volume	65

Access to Document

https://jnm.snmjournals.org/content/65/supplement_2/242090License: Unspecified

Cite this

Andersson, M., Goudin, N., Pontoglio, M., Levillain, H., Reynaert, N., & Saldarriaga Vargas, C. (2024). Development of mouse kidney models on a nephron scale and influence of non-uniform activity distribution on preclinical renal dosimetry. In Meeting ReportMolecular Targeting Probes-Radioactive & Nonradioactive - Dosimetry & Image Analysis Article 242090 (The journal of nuclear medicine; Vol. 65, No. Supplement 2). SNMMI - Society of Nuclear Medicine and Molecular Imaging. https://jnm.snmjournals.org/content/65/supplement_2/242090

Andersson, Michelle ; Goudin, Nicolas ; Pontoglio, Marco et al. / Development of mouse kidney models on a nephron scale and influence of non-uniform activity distribution on preclinical renal dosimetry. Meeting ReportMolecular Targeting Probes-Radioactive & Nonradioactive - Dosimetry & Image Analysis. SNMMI - Society of Nuclear Medicine and Molecular Imaging, 2024. (The journal of nuclear medicine; Supplement 2).

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abstract = "Nephrotoxicity is often the dose-limiting factor in Targeted Radionuclide Therapy (TRT) due to the clearance of radiopharmaceuticals through the kidneys. Small radiolabeled peptides are often reabsorbed in the proximal tubules (PT), leading to a heterogeneous dose distribution in nephrons and even within nephron sub-compartments (Glomerulus (GL) , PT, Distal Tubule and Loop of Henle) [1]. In order to investigate factors affecting nephrotoxicity in a controlled manner, preclinical investigations are of great importance. This study investigated the influence of nephron type and morphology on murine nephron dosimetry, as well as the effect of heterogeneous activity distribution in nephrons on kidney tissue dosimetry by developing a 3D multi-nephron anatomical model for dosimetric calculations.",

keywords = "Preclinical dosimetry, Nephrotoxicity, Targeted Radionuclide Therapy",

author = "Michelle Andersson and Nicolas Goudin and Marco Pontoglio and Hugo Levillain and Nick Reynaert and {Saldarriaga Vargas}, Clarita",

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Andersson, M, Goudin, N, Pontoglio, M, Levillain, H, Reynaert, N & Saldarriaga Vargas, C 2024, Development of mouse kidney models on a nephron scale and influence of non-uniform activity distribution on preclinical renal dosimetry. in Meeting ReportMolecular Targeting Probes-Radioactive & Nonradioactive - Dosimetry & Image Analysis., 242090, The journal of nuclear medicine, no. Supplement 2, vol. 65, SNMMI - Society of Nuclear Medicine and Molecular Imaging. <https://jnm.snmjournals.org/content/65/supplement_2/242090>

Development of mouse kidney models on a nephron scale and influence of non-uniform activity distribution on preclinical renal dosimetry. / Andersson, Michelle; Goudin, Nicolas; Pontoglio, Marco et al.
Meeting ReportMolecular Targeting Probes-Radioactive & Nonradioactive - Dosimetry & Image Analysis. SNMMI - Society of Nuclear Medicine and Molecular Imaging, 2024. 242090 (The journal of nuclear medicine; Vol. 65, No. Supplement 2).

Research output › peer-review

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T1 - Development of mouse kidney models on a nephron scale and influence of non-uniform activity distribution on preclinical renal dosimetry

AU - Andersson, Michelle

AU - Goudin, Nicolas

AU - Pontoglio, Marco

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AU - Reynaert, Nick

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AB - Nephrotoxicity is often the dose-limiting factor in Targeted Radionuclide Therapy (TRT) due to the clearance of radiopharmaceuticals through the kidneys. Small radiolabeled peptides are often reabsorbed in the proximal tubules (PT), leading to a heterogeneous dose distribution in nephrons and even within nephron sub-compartments (Glomerulus (GL) , PT, Distal Tubule and Loop of Henle) [1]. In order to investigate factors affecting nephrotoxicity in a controlled manner, preclinical investigations are of great importance. This study investigated the influence of nephron type and morphology on murine nephron dosimetry, as well as the effect of heterogeneous activity distribution in nephrons on kidney tissue dosimetry by developing a 3D multi-nephron anatomical model for dosimetric calculations.

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KW - Nephrotoxicity

KW - Targeted Radionuclide Therapy

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Andersson M, Goudin N, Pontoglio M, Levillain H, Reynaert N, Saldarriaga Vargas C. Development of mouse kidney models on a nephron scale and influence of non-uniform activity distribution on preclinical renal dosimetry. In Meeting ReportMolecular Targeting Probes-Radioactive & Nonradioactive - Dosimetry & Image Analysis. SNMMI - Society of Nuclear Medicine and Molecular Imaging. 2024. 242090. (The journal of nuclear medicine; Supplement 2).