@inproceedings{d4fcd9a23a174d90a6d38d976f1f6079,
title = "Development of mouse kidney models on a nephron scale and influence of non-uniform activity distribution on preclinical renal dosimetry",
abstract = "Nephrotoxicity is often the dose-limiting factor in Targeted Radionuclide Therapy (TRT) due to the clearance of radiopharmaceuticals through the kidneys. Small radiolabeled peptides are often reabsorbed in the proximal tubules (PT), leading to a heterogeneous dose distribution in nephrons and even within nephron sub-compartments (Glomerulus (GL) , PT, Distal Tubule and Loop of Henle) [1]. In order to investigate factors affecting nephrotoxicity in a controlled manner, preclinical investigations are of great importance. This study investigated the influence of nephron type and morphology on murine nephron dosimetry, as well as the effect of heterogeneous activity distribution in nephrons on kidney tissue dosimetry by developing a 3D multi-nephron anatomical model for dosimetric calculations.",
keywords = "Preclinical dosimetry, Nephrotoxicity, Targeted Radionuclide Therapy",
author = "Michelle Andersson and Nicolas Goudin and Marco Pontoglio and Hugo Levillain and Nick Reynaert and \{Saldarriaga Vargas\}, Clarita",
note = "Score=3; 2024 - SNMMI : Annual Meeting Exhibits and Sponsorship ; Conference date: 08-06-2024 Through 11-06-2024",
year = "2024",
month = jun,
language = "English",
series = "The journal of nuclear medicine",
publisher = "SNMMI - Society of Nuclear Medicine and Molecular Imaging",
number = "Supplement 2",
booktitle = "Meeting ReportMolecular Targeting Probes-Radioactive \& Nonradioactive - Dosimetry \& Image Analysis",
}