Dominant lethal test in female mice treated with methyl mercury chloride

L. Verschaeve; A. Léonard

doi:10.1016/0165-1218(84)90155-1

Dominant lethal test in female mice treated with methyl mercury chloride

L. Verschaeve, A. Léonard

Research output › peer-review

Abstract

Female BALB/c mice were treated with a single intraperitoneal injection of 0, 2.5, 5.0 or 7.5 mg methyl mercury chloride per kg body weight and subjected to the dominant lethal assay at 6 different time intervals between exposure and mating. Cyclophosphamide (210 mg/kg body weight) was used as a positive control. The main observation appeared to be a statistically highly significant increase in especially pre- and early post-implantation foetal losses. This was most evident when all data (the 6 consecutive weeks of mating) were pooled.

Original language	English
Pages (from-to)	131-136
Number of pages	6
Journal	Mutation Research/Genetic Toxicology
Volume	136
Issue number	2
DOIs	https://doi.org/10.1016/0165-1218(84)90155-1
State	Published - May 1984

ASJC Scopus subject areas

Toxicology
Genetics

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10.1016/0165-1218(84)90155-1

Cite this

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title = "Dominant lethal test in female mice treated with methyl mercury chloride",

abstract = "Female BALB/c mice were treated with a single intraperitoneal injection of 0, 2.5, 5.0 or 7.5 mg methyl mercury chloride per kg body weight and subjected to the dominant lethal assay at 6 different time intervals between exposure and mating. Cyclophosphamide (210 mg/kg body weight) was used as a positive control. The main observation appeared to be a statistically highly significant increase in especially pre- and early post-implantation foetal losses. This was most evident when all data (the 6 consecutive weeks of mating) were pooled.",

author = "L. Verschaeve and A. L{\'e}onard",

year = "1984",

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AU - Léonard, A.

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AB - Female BALB/c mice were treated with a single intraperitoneal injection of 0, 2.5, 5.0 or 7.5 mg methyl mercury chloride per kg body weight and subjected to the dominant lethal assay at 6 different time intervals between exposure and mating. Cyclophosphamide (210 mg/kg body weight) was used as a positive control. The main observation appeared to be a statistically highly significant increase in especially pre- and early post-implantation foetal losses. This was most evident when all data (the 6 consecutive weeks of mating) were pooled.

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