Effect of total-body x-irradiation and of chemical protector AET administration on the activity of nuclear RNA-polymerase in regenerating rat liver

R. Vandergoten; R. Goutier

doi:10.1080/09553006614551231

Effect of total-body x-irradiation and of chemical protector AET administration on the activity of nuclear RNA-polymerase in regenerating rat liver

R. Vandergoten, R. Goutier

Research output › peer-review

Abstract

Nuclear RNA-polymerase activity has been measured in regenerating liver of rats which received before hepatectomy either an injection of AET or a whole-body x-irradiation of 1000 R or a combination of both treatments. AET injection, 1 hour before hepatectomy, delays the increase in enzyme activity still more than does irradiation. No protective effect of AET is observed in rats treated 1 hour before partial hepatectomy, probably because of the higher toxicity of AET to hepatectomized rats. A protective action is, however, detected when AET and irradiation are given 12 hours before partial hepatectomy.

Original language	English
Pages (from-to)	449-454
Number of pages	6
Journal	International Journal of Radiation Biology
Volume	11
Issue number	5
DOIs	https://doi.org/10.1080/09553006614551231
State	Published - 1966
Externally published	Yes

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

Access to Document

10.1080/09553006614551231

Cite this

@article{2869ce65b00a4a07a07cce195e669ee8,

title = "Effect of total-body x-irradiation and of chemical protector AET administration on the activity of nuclear RNA-polymerase in regenerating rat liver",

abstract = "Nuclear RNA-polymerase activity has been measured in regenerating liver of rats which received before hepatectomy either an injection of AET or a whole-body x-irradiation of 1000 R or a combination of both treatments. AET injection, 1 hour before hepatectomy, delays the increase in enzyme activity still more than does irradiation. No protective effect of AET is observed in rats treated 1 hour before partial hepatectomy, probably because of the higher toxicity of AET to hepatectomized rats. A protective action is, however, detected when AET and irradiation are given 12 hours before partial hepatectomy.",

author = "R. Vandergoten and R. Goutier",

year = "1966",

doi = "10.1080/09553006614551231",

language = "English",

volume = "11",

pages = "449--454",

journal = "International Journal of Radiation Biology",

issn = "0955-3002",

publisher = "Taylor & Francis (CRC)",

number = "5",

}

TY - JOUR

T1 - Effect of total-body x-irradiation and of chemical protector AET administration on the activity of nuclear RNA-polymerase in regenerating rat liver

AU - Vandergoten, R.

AU - Goutier, R.

PY - 1966

Y1 - 1966

N2 - Nuclear RNA-polymerase activity has been measured in regenerating liver of rats which received before hepatectomy either an injection of AET or a whole-body x-irradiation of 1000 R or a combination of both treatments. AET injection, 1 hour before hepatectomy, delays the increase in enzyme activity still more than does irradiation. No protective effect of AET is observed in rats treated 1 hour before partial hepatectomy, probably because of the higher toxicity of AET to hepatectomized rats. A protective action is, however, detected when AET and irradiation are given 12 hours before partial hepatectomy.

AB - Nuclear RNA-polymerase activity has been measured in regenerating liver of rats which received before hepatectomy either an injection of AET or a whole-body x-irradiation of 1000 R or a combination of both treatments. AET injection, 1 hour before hepatectomy, delays the increase in enzyme activity still more than does irradiation. No protective effect of AET is observed in rats treated 1 hour before partial hepatectomy, probably because of the higher toxicity of AET to hepatectomized rats. A protective action is, however, detected when AET and irradiation are given 12 hours before partial hepatectomy.

UR - http://www.scopus.com/inward/record.url?scp=0013987627&partnerID=8YFLogxK

U2 - 10.1080/09553006614551231

DO - 10.1080/09553006614551231

M3 - Article

C2 - 5297667

AN - SCOPUS:0013987627

SN - 0955-3002

VL - 11

SP - 449

EP - 454

JO - International Journal of Radiation Biology

JF - International Journal of Radiation Biology

IS - 5

ER -