Irradiation (IR) of pregnant mother is known for its potential inducing of foetal lethality and/or malformations. However involved mechanisms remain to be unravelled. It’s assumed that the major part of IR effects are due to DNA damages. Then a gene expression analysis could allow to determine what are genes modulated by IR and what are pathways involved. For this aim, it’s first necessary to set up a model of radiation-induced malformation. The more frequent external malformation is the exencephaly, which has been chosen as model. Different dose of irradiation have been tested at different stage of the embryogenesis for obtaining the maximum of exencephaly without inducing other malformations. By considering the first day as day 0, the day 8 presents the maximum of exencephaly for an irradiation of 1 Gy of CF1 pregnant mice. However this dose induces other malformations and the dose of 0.4 Gy is not sufficient to induce a significant increase of exencephaly. Then a dose of 0.7 Gy must be more appropriate for this model.
|Place of Publication||Louvain La Neuve, Belgium|
|State||Published - 30 Sep 2008|