Effects of 1 Gy and 0.4 Gy of X-Rays irradiation on induction of external malformations in CF1 mice

Vivien Labat-Gest; Paul Jacquet; Nada Samari; Jasmine Buset; Louis de Saint-Georges; Hanane Derradji

Effects of 1 Gy and 0.4 Gy of X-Rays irradiation on induction of external malformations in CF1 mice

Vivien Labat-Gest, Paul Jacquet, Nada Samari, Jasmine Buset, Louis de Saint-Georges, Hanane Derradji

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Abstract

Irradiation (IR) of pregnant mother is known for its potential inducing of foetal lethality and/or malformations. However involved mechanisms remain to be unravelled. It’s assumed that the major part of IR effects are due to DNA damages. Then a gene expression analysis could allow to determine what are genes modulated by IR and what are pathways involved. For this aim, it’s first necessary to set up a model of radiation-induced malformation. The more frequent external malformation is the exencephaly, which has been chosen as model. Different dose of irradiation have been tested at different stage of the embryogenesis for obtaining the maximum of exencephaly without inducing other malformations. By considering the first day as day 0, the day 8 presents the maximum of exencephaly for an irradiation of 1 Gy of CF1 pregnant mice. However this dose induces other malformations and the dose of 0.4 Gy is not sufficient to induce a significant increase of exencephaly. Then a dose of 0.7 Gy must be more appropriate for this model.

Original language	English
Awarding Institution	UCL - Université catholique de Louvain
Supervisors/Advisors	Benotmane, Rafi, Supervisor
Place of Publication	Louvain La Neuve, Belgium
Publisher	UCL - Université Catholique de Louvain
State	Published - 30 Sep 2008

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Effects of 1 Gy and 0.4 Gy of X-Rays irradiation on induction of external malformations in CF1 miceFinal published version, 3.92 MBLicense: Unspecified

Cite this

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title = "Effects of 1 Gy and 0.4 Gy of X-Rays irradiation on induction of external malformations in CF1 mice",

abstract = "Irradiation (IR) of pregnant mother is known for its potential inducing of foetal lethality and/or malformations. However involved mechanisms remain to be unravelled. It{\textquoteright}s assumed that the major part of IR effects are due to DNA damages. Then a gene expression analysis could allow to determine what are genes modulated by IR and what are pathways involved. For this aim, it{\textquoteright}s first necessary to set up a model of radiation-induced malformation. The more frequent external malformation is the exencephaly, which has been chosen as model. Different dose of irradiation have been tested at different stage of the embryogenesis for obtaining the maximum of exencephaly without inducing other malformations. By considering the first day as day 0, the day 8 presents the maximum of exencephaly for an irradiation of 1 Gy of CF1 pregnant mice. However this dose induces other malformations and the dose of 0.4 Gy is not sufficient to induce a significant increase of exencephaly. Then a dose of 0.7 Gy must be more appropriate for this model.",

keywords = "Brain, Irradiation, malformation",

author = "Vivien Labat-Gest and Paul Jacquet and Nada Samari and Jasmine Buset and {de Saint-Georges}, Louis and Hanane Derradji",

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year = "2008",

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T1 - Effects of 1 Gy and 0.4 Gy of X-Rays irradiation on induction of external malformations in CF1 mice

AU - Labat-Gest, Vivien

AU - Jacquet, Paul

AU - Samari, Nada

AU - Buset, Jasmine

A2 - de Saint-Georges, Louis

A2 - Derradji, Hanane

N1 - Score = 2

PY - 2008/9/30

Y1 - 2008/9/30

N2 - Irradiation (IR) of pregnant mother is known for its potential inducing of foetal lethality and/or malformations. However involved mechanisms remain to be unravelled. It’s assumed that the major part of IR effects are due to DNA damages. Then a gene expression analysis could allow to determine what are genes modulated by IR and what are pathways involved. For this aim, it’s first necessary to set up a model of radiation-induced malformation. The more frequent external malformation is the exencephaly, which has been chosen as model. Different dose of irradiation have been tested at different stage of the embryogenesis for obtaining the maximum of exencephaly without inducing other malformations. By considering the first day as day 0, the day 8 presents the maximum of exencephaly for an irradiation of 1 Gy of CF1 pregnant mice. However this dose induces other malformations and the dose of 0.4 Gy is not sufficient to induce a significant increase of exencephaly. Then a dose of 0.7 Gy must be more appropriate for this model.

AB - Irradiation (IR) of pregnant mother is known for its potential inducing of foetal lethality and/or malformations. However involved mechanisms remain to be unravelled. It’s assumed that the major part of IR effects are due to DNA damages. Then a gene expression analysis could allow to determine what are genes modulated by IR and what are pathways involved. For this aim, it’s first necessary to set up a model of radiation-induced malformation. The more frequent external malformation is the exencephaly, which has been chosen as model. Different dose of irradiation have been tested at different stage of the embryogenesis for obtaining the maximum of exencephaly without inducing other malformations. By considering the first day as day 0, the day 8 presents the maximum of exencephaly for an irradiation of 1 Gy of CF1 pregnant mice. However this dose induces other malformations and the dose of 0.4 Gy is not sufficient to induce a significant increase of exencephaly. Then a dose of 0.7 Gy must be more appropriate for this model.

KW - Brain

KW - Irradiation

KW - malformation

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_93999

M3 - Master's thesis

PB - UCL - Université Catholique de Louvain

CY - Louvain La Neuve, Belgium

ER -