Effects of long-term lead exposure on monkey leukocyte chromosomes

P. Jacquet; P. Tachon

doi:10.1016/0378-4274(81)90045-X

Effects of long-term lead exposure on monkey leukocyte chromosomes

P. Jacquet, P. Tachon

Research output › peer-review

Abstract

Cynomolgus monkeys (Macaca irus) received daily doses of 1 or 5 mg of lead for a period of 12 months. Samples of venous blood were taken at 0, 7, 9 and 12 months, and cultured lymphocytes were analysed for the presence of chromosome aberrations. A few severe chromosome aberrations, such as dicentrics or translocations, appeared in the control animals as well as in the lead-treated ones, during the course of the experiment. However, lead treatment increased significantly the frequency of chromosome and chromatid gaps, and this result is in agreement with other previous results.

Original language	English
Pages (from-to)	165-169
Number of pages	5
Journal	Toxicology Letters
Volume	8
Issue number	3
DOIs	https://doi.org/10.1016/0378-4274(81)90045-X
State	Published - May 1981

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(81)90045-X

Cite this

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title = "Effects of long-term lead exposure on monkey leukocyte chromosomes",

abstract = "Cynomolgus monkeys (Macaca irus) received daily doses of 1 or 5 mg of lead for a period of 12 months. Samples of venous blood were taken at 0, 7, 9 and 12 months, and cultured lymphocytes were analysed for the presence of chromosome aberrations. A few severe chromosome aberrations, such as dicentrics or translocations, appeared in the control animals as well as in the lead-treated ones, during the course of the experiment. However, lead treatment increased significantly the frequency of chromosome and chromatid gaps, and this result is in agreement with other previous results.",

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AU - Tachon, P.

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N2 - Cynomolgus monkeys (Macaca irus) received daily doses of 1 or 5 mg of lead for a period of 12 months. Samples of venous blood were taken at 0, 7, 9 and 12 months, and cultured lymphocytes were analysed for the presence of chromosome aberrations. A few severe chromosome aberrations, such as dicentrics or translocations, appeared in the control animals as well as in the lead-treated ones, during the course of the experiment. However, lead treatment increased significantly the frequency of chromosome and chromatid gaps, and this result is in agreement with other previous results.

AB - Cynomolgus monkeys (Macaca irus) received daily doses of 1 or 5 mg of lead for a period of 12 months. Samples of venous blood were taken at 0, 7, 9 and 12 months, and cultured lymphocytes were analysed for the presence of chromosome aberrations. A few severe chromosome aberrations, such as dicentrics or translocations, appeared in the control animals as well as in the lead-treated ones, during the course of the experiment. However, lead treatment increased significantly the frequency of chromosome and chromatid gaps, and this result is in agreement with other previous results.

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