Enhancing European capabilities for application of multi-omics studies in biology and biomedicine space research

Aránzazu Manzano; Silvio Weging; Daniela Bezdan; Joseph Borg; Thomas Cahill; Eugénie Carnero-Diaz; Henry Cope; Colleen S. Deane; Timothy Etheridge; Stefania Giacomello; Gary Hardiman; Natalie Leys; Pedro Madrigal; Felice Mastroleo; F. Javier Medina; Jakub Mieczkowski; Manuel A. Fernandez-Rojo; Keith Siew; Nathaniel J. Szewczyk; Stephen B. Walsh; Willian A. da Silveira; Raúl Herranz

doi:10.1016/j.isci.2023.107289

Enhancing European capabilities for application of multi-omics studies in biology and biomedicine space research

Aránzazu Manzano, Silvio Weging, Daniela Bezdan, Joseph Borg, Thomas Cahill, Eugénie Carnero-Diaz, Henry Cope, Colleen S. Deane, Timothy Etheridge, Stefania Giacomello, Gary Hardiman, Natalie Leys, Pedro Madrigal, Felice Mastroleo, F. Javier Medina, Jakub Mieczkowski, Manuel A. Fernandez-Rojo, Keith Siew, Nathaniel J. Szewczyk, Stephen B. WalshWillian A. da Silveira, Raúl Herranz

Research output › peer-review

Abstract

Following on from the NASA twins’ study, there has been a tremendous interest in the use of omics techniques in spaceflight. Individual space agencies, NASA's GeneLab, JAXA's ibSLS, and the ESA-funded Space Omics Topical Team and the International Standards for Space Omics Processing (ISSOP) groups have established several initiatives to support this growth. Here, we present recommendations from the Space Omics Topical Team to promote standard application of space omics in Europe. We focus on four main themes: i) continued participation in and coordination with international omics endeavors, ii) strengthening of the European space omics infrastructure including workforce and facilities, iii) capitalizing on the emerging opportunities in the commercial space sector, and iv) capitalizing on the emerging opportunities in human subjects research.

Original language	English
Article number	107289
Journal	iScience
Volume	26
Issue number	9
DOIs	https://doi.org/10.1016/j.isci.2023.107289
State	Published - 15 Sep 2023

ASJC Scopus subject areas

General

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https://www.sciencedirect.com/science/article/pii/S2589004223013664

Cite this

Manzano, A., Weging, S., Bezdan, D., Borg, J., Cahill, T., Carnero-Diaz, E., Cope, H., Deane, C. S., Etheridge, T., Giacomello, S., Hardiman, G., Leys, N., Madrigal, P., Mastroleo, F., Medina, F. J., Mieczkowski, J., Fernandez-Rojo, M. A., Siew, K., Szewczyk, N. J., ... Herranz, R. (2023). Enhancing European capabilities for application of multi-omics studies in biology and biomedicine space research. iScience, 26(9), [107289]. https://doi.org/10.1016/j.isci.2023.107289

@article{efb67be989044a56a65f3f97aa7e2bcf,

title = "Enhancing European capabilities for application of multi-omics studies in biology and biomedicine space research",

abstract = "Following on from the NASA twins{\textquoteright} study, there has been a tremendous interest in the use of omics techniques in spaceflight. Individual space agencies, NASA's GeneLab, JAXA's ibSLS, and the ESA-funded Space Omics Topical Team and the International Standards for Space Omics Processing (ISSOP) groups have established several initiatives to support this growth. Here, we present recommendations from the Space Omics Topical Team to promote standard application of space omics in Europe. We focus on four main themes: i) continued participation in and coordination with international omics endeavors, ii) strengthening of the European space omics infrastructure including workforce and facilities, iii) capitalizing on the emerging opportunities in the commercial space sector, and iv) capitalizing on the emerging opportunities in human subjects research.",

keywords = "NASA, Space omics, Emerging commercial space sector, Human subjects, ESA, ISSOP, Genomics, Proteomics, Space medicine, Space sciences",

author = "Ar{\'a}nzazu Manzano and Silvio Weging and Daniela Bezdan and Joseph Borg and Thomas Cahill and Eug{\'e}nie Carnero-Diaz and Henry Cope and Deane, {Colleen S.} and Timothy Etheridge and Stefania Giacomello and Gary Hardiman and Natalie Leys and Pedro Madrigal and Felice Mastroleo and Medina, {F. Javier} and Jakub Mieczkowski and Fernandez-Rojo, {Manuel A.} and Keith Siew and Szewczyk, {Nathaniel J.} and Walsh, {Stephen B.} and Silveira, {Willian A. da} and Ra{\'u}l Herranz",

note = "Score=10 Funding Information: All listed authors are members of the ESA Space Omics Topical Team, funded by the ESA grant/contract 4000131202/20/NL/PG/pt “Space Omics: Toward an integrated ESA/NASA –omics database for spaceflight and ground facilities experiments” awarded to RH, which was the main funding source for this work. Individual authors also acknowledge support from: the Horizon Center for Doctoral Training at the University of Nottingham [UKRI grant no. EP/S023305/1] to H.C. the Medical Research Council part of a Skills Development Fellowship [grant number MR/T026014/1] awarded to C.S.D.; the Spanish Comunidad Autonoma de Madrid TALENTO Modalidad-1 program project 2020-5A_BIO-19724 to M.A.F.R.; the Spanish National Research Council Grant 2021AEP135 to F.J.M. & R.H. the Swedish Research Council VR grant 2020-04864 to S.G. and the French Centre National d'Etudes Spatiales grant DAR 2020-4800001004, 2021-4800001117 to E.C.D. This research was also funded in part by the Wellcome Trust [110182/Z/15/Z] to K.S. N.J.S. acknowledges the support of the Osteopathic Heritage Foundation through funding for the Osteopathic Heritage Foundation Ralph S. Licklider, D.O. Research Endowment in the Heritage College of Osteopathic Medicine. For the purpose of open access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. Conceptualization and methodology, A.M. S.W. and R.H.; original draft preparation, A.M. S.W. and R.H.; subsection contributions, review, and editing, all authors; academic English review, C.S.D. K.S. and S.B.W.; project administration and editing, S.G. D.B. N.J.S. W.d.S. and R.H.; funding acquisition, R.H. All authors have read and agreed to the published version of the manuscript. F.M. is CEO/Co-Founder at Genegoggle, D.B. is a cofounder of Poppy Health, Inc. and CSO of Yuri Gravity GmbH and declares affiliations at the NGS Competence Center T{\"u}bingen (NCCT), University of T{\"u}bingen, T{\"u}bingen and Yuri Gravity, Meckenbeuren, Germany. M.F.R. declares additional affiliation at Diamantina Institute, The University of Queensland, St Lucia, Queensland 4072, Australia. S.G. is a scientific consultant of 10x Genomics. One or more of the authors of this paper self-identifies as an underrepresented ethnic minority in their field of research or within their geographical location. One or more of the authors of this paper self-identifies as a gender minority in their field of research. One or more of the authors of this paper self-identifies as a member of the LGBTQIA+ community. We avoided “helicopter science” practices by including the participating local contributors from the region where we conducted the research as authors on the paper. Funding Information: All listed authors are members of the ESA Space Omics Topical Team, funded by the ESA grant/contract 4000131202/20/NL/PG/pt “Space Omics: Toward an integrated ESA/NASA –omics database for spaceflight and ground facilities experiments” awarded to RH, which was the main funding source for this work. Individual authors also acknowledge support from: the Horizon Center for Doctoral Training at the University of Nottingham [ UKRI grant no. EP/S023305/1 ] to H.C., the Medical Research Council part of a Skills Development Fellowship [grant number MR/T026014/1 ] awarded to C.S.D.; the Spanish Comunidad Autonoma de Madrid TALENTO Modalidad-1 program project 2020-5A_BIO-19724 to M.A.F.R.; the Spanish National Research Council Grant 2021AEP135 to F.J.M. & R.H., the Swedish Research Council VR grant 2020-04864 to S.G. and the French Centre National d'Etudes Spatiales grant DAR 2020-4800001004 , 2021-4800001117 to E.C.D. This research was also funded in part by the Wellcome Trust [ 110182/Z/15/Z ] to K.S. N.J.S. acknowledges the support of the Osteopathic Heritage Foundation through funding for the Osteopathic Heritage Foundation Ralph S. Licklider, D.O., Research Endowment in the Heritage College of Osteopathic Medicine . For the purpose of open access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = sep,

day = "15",

doi = "10.1016/j.isci.2023.107289",

language = "English",

volume = "26",

journal = "iScience",

issn = "2589-0042",

publisher = "Elsevier",

number = "9",

}

Manzano, A, Weging, S, Bezdan, D, Borg, J, Cahill, T, Carnero-Diaz, E, Cope, H, Deane, CS, Etheridge, T, Giacomello, S, Hardiman, G, Leys, N, Madrigal, P, Mastroleo, F, Medina, FJ, Mieczkowski, J, Fernandez-Rojo, MA, Siew, K, Szewczyk, NJ, Walsh, SB, Silveira, WAD & Herranz, R 2023, 'Enhancing European capabilities for application of multi-omics studies in biology and biomedicine space research', iScience, vol. 26, no. 9, 107289. https://doi.org/10.1016/j.isci.2023.107289

TY - JOUR

T1 - Enhancing European capabilities for application of multi-omics studies in biology and biomedicine space research

AU - Manzano, Aránzazu

AU - Weging, Silvio

AU - Bezdan, Daniela

AU - Borg, Joseph

AU - Cahill, Thomas

AU - Carnero-Diaz, Eugénie

AU - Cope, Henry

AU - Deane, Colleen S.

AU - Etheridge, Timothy

AU - Giacomello, Stefania

AU - Hardiman, Gary

AU - Leys, Natalie

AU - Madrigal, Pedro

AU - Mastroleo, Felice

AU - Medina, F. Javier

AU - Mieczkowski, Jakub

AU - Fernandez-Rojo, Manuel A.

AU - Siew, Keith

AU - Szewczyk, Nathaniel J.

AU - Walsh, Stephen B.

AU - Silveira, Willian A. da

AU - Herranz, Raúl

N1 - Score=10 Funding Information: All listed authors are members of the ESA Space Omics Topical Team, funded by the ESA grant/contract 4000131202/20/NL/PG/pt “Space Omics: Toward an integrated ESA/NASA –omics database for spaceflight and ground facilities experiments” awarded to RH, which was the main funding source for this work. Individual authors also acknowledge support from: the Horizon Center for Doctoral Training at the University of Nottingham [UKRI grant no. EP/S023305/1] to H.C. the Medical Research Council part of a Skills Development Fellowship [grant number MR/T026014/1] awarded to C.S.D.; the Spanish Comunidad Autonoma de Madrid TALENTO Modalidad-1 program project 2020-5A_BIO-19724 to M.A.F.R.; the Spanish National Research Council Grant 2021AEP135 to F.J.M. & R.H. the Swedish Research Council VR grant 2020-04864 to S.G. and the French Centre National d'Etudes Spatiales grant DAR 2020-4800001004, 2021-4800001117 to E.C.D. This research was also funded in part by the Wellcome Trust [110182/Z/15/Z] to K.S. N.J.S. acknowledges the support of the Osteopathic Heritage Foundation through funding for the Osteopathic Heritage Foundation Ralph S. Licklider, D.O. Research Endowment in the Heritage College of Osteopathic Medicine. For the purpose of open access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. Conceptualization and methodology, A.M. S.W. and R.H.; original draft preparation, A.M. S.W. and R.H.; subsection contributions, review, and editing, all authors; academic English review, C.S.D. K.S. and S.B.W.; project administration and editing, S.G. D.B. N.J.S. W.d.S. and R.H.; funding acquisition, R.H. All authors have read and agreed to the published version of the manuscript. F.M. is CEO/Co-Founder at Genegoggle, D.B. is a cofounder of Poppy Health, Inc. and CSO of Yuri Gravity GmbH and declares affiliations at the NGS Competence Center Tübingen (NCCT), University of Tübingen, Tübingen and Yuri Gravity, Meckenbeuren, Germany. M.F.R. declares additional affiliation at Diamantina Institute, The University of Queensland, St Lucia, Queensland 4072, Australia. S.G. is a scientific consultant of 10x Genomics. One or more of the authors of this paper self-identifies as an underrepresented ethnic minority in their field of research or within their geographical location. One or more of the authors of this paper self-identifies as a gender minority in their field of research. One or more of the authors of this paper self-identifies as a member of the LGBTQIA+ community. We avoided “helicopter science” practices by including the participating local contributors from the region where we conducted the research as authors on the paper. Funding Information: All listed authors are members of the ESA Space Omics Topical Team, funded by the ESA grant/contract 4000131202/20/NL/PG/pt “Space Omics: Toward an integrated ESA/NASA –omics database for spaceflight and ground facilities experiments” awarded to RH, which was the main funding source for this work. Individual authors also acknowledge support from: the Horizon Center for Doctoral Training at the University of Nottingham [ UKRI grant no. EP/S023305/1 ] to H.C., the Medical Research Council part of a Skills Development Fellowship [grant number MR/T026014/1 ] awarded to C.S.D.; the Spanish Comunidad Autonoma de Madrid TALENTO Modalidad-1 program project 2020-5A_BIO-19724 to M.A.F.R.; the Spanish National Research Council Grant 2021AEP135 to F.J.M. & R.H., the Swedish Research Council VR grant 2020-04864 to S.G. and the French Centre National d'Etudes Spatiales grant DAR 2020-4800001004 , 2021-4800001117 to E.C.D. This research was also funded in part by the Wellcome Trust [ 110182/Z/15/Z ] to K.S. N.J.S. acknowledges the support of the Osteopathic Heritage Foundation through funding for the Osteopathic Heritage Foundation Ralph S. Licklider, D.O., Research Endowment in the Heritage College of Osteopathic Medicine . For the purpose of open access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. Publisher Copyright: © 2023 The Authors

PY - 2023/9/15

Y1 - 2023/9/15

N2 - Following on from the NASA twins’ study, there has been a tremendous interest in the use of omics techniques in spaceflight. Individual space agencies, NASA's GeneLab, JAXA's ibSLS, and the ESA-funded Space Omics Topical Team and the International Standards for Space Omics Processing (ISSOP) groups have established several initiatives to support this growth. Here, we present recommendations from the Space Omics Topical Team to promote standard application of space omics in Europe. We focus on four main themes: i) continued participation in and coordination with international omics endeavors, ii) strengthening of the European space omics infrastructure including workforce and facilities, iii) capitalizing on the emerging opportunities in the commercial space sector, and iv) capitalizing on the emerging opportunities in human subjects research.

AB - Following on from the NASA twins’ study, there has been a tremendous interest in the use of omics techniques in spaceflight. Individual space agencies, NASA's GeneLab, JAXA's ibSLS, and the ESA-funded Space Omics Topical Team and the International Standards for Space Omics Processing (ISSOP) groups have established several initiatives to support this growth. Here, we present recommendations from the Space Omics Topical Team to promote standard application of space omics in Europe. We focus on four main themes: i) continued participation in and coordination with international omics endeavors, ii) strengthening of the European space omics infrastructure including workforce and facilities, iii) capitalizing on the emerging opportunities in the commercial space sector, and iv) capitalizing on the emerging opportunities in human subjects research.

KW - NASA

KW - Space omics

KW - Emerging commercial space sector

KW - Human subjects

KW - ESA

KW - ISSOP

KW - Genomics

KW - Proteomics

KW - Space medicine

KW - Space sciences

UR - http://www.scopus.com/inward/record.url?scp=85167839278&partnerID=8YFLogxK

U2 - 10.1016/j.isci.2023.107289

DO - 10.1016/j.isci.2023.107289

M3 - Article

SN - 2589-0042

VL - 26

JO - iScience

JF - iScience

IS - 9

M1 - 107289

ER -