To study the effects of space travel, with emphasis on ionizing radiation, a pluralistic setup was developed to measure DNA damage and inflammation response through a combination of global and local dosimetry, image cytomety and multiplex array technology. 3 different cell types, normal human dermal fibroblasts (NHDFc), Lamin Knock out fibroblasts (LaKo) and Progeria fibroblasts were prepared in 12 different modules for space travel. Intra- and intercellular stress response in human fibroblasts was assessed. To study the combined biological effects of cosmic radiation and microgravity on human cells, live biological samples of human fibroblasts were sent to space within the Foton-M3 mission on September,14, 2007 from the Baikonur Cosmodrome in Kazakhstan with a Soyuz-U rocket launcher. Following the launch phase, Foton completed a 190 circular orbits around the earth, at 63° inclination, within an altitude range of 260- 305 km, in 12 days.
|Number of pages
|Published - 25 Jun 2008
|Studiecentrum voor Kernenergie