Gene expression induced by X-ray irradiation in human blood cell lines

M. Mori; M. A. Benotmane; J. Verheyde; P. Van Hummelen; E. L. Hooghe-Peters; C. Desaintes

doi:10.1196/annals.1299.061

Gene expression induced by X-ray irradiation in human blood cell lines

M. Mori, M. A. Benotmane, J. Verheyde, P. Van Hummelen, E. L. Hooghe-Peters, C. Desaintes

Research output › peer-review

Abstract

The response to X-ray irradiation of three different human hematopoietic cell lines originating from T (Jurkat), B (Raji), and promyelocytic (HL60) leukemia was analyzed. The survival after irradiation differed among the three cell lines, with Jurkat cells being the most vulnerable and HL60 being the least sensitive. The profile of gene expression was studied with the microarray technique in both Jurkat and HL60 cell lines. Out of the 13,800 different genes spotted on microarrays, very few genes (<0.5%) appeared to be induced more than 2-fold or repressed more than 2.5-fold in both cell lines.

Original language	English
Pages (from-to)	339-341
Number of pages	3
Journal	Annals of the New York Academy of Science
Volume	1010
Issue number	1
DOIs	https://doi.org/10.1196/annals.1299.061
State	Published - Dec 2003

ASJC Scopus subject areas

General Neuroscience
General Biochemistry,Genetics and Molecular Biology
History and Philosophy of Science

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Cite this

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title = "Gene expression induced by X-ray irradiation in human blood cell lines",

abstract = "The response to X-ray irradiation of three different human hematopoietic cell lines originating from T (Jurkat), B (Raji), and promyelocytic (HL60) leukemia was analyzed. The survival after irradiation differed among the three cell lines, with Jurkat cells being the most vulnerable and HL60 being the least sensitive. The profile of gene expression was studied with the microarray technique in both Jurkat and HL60 cell lines. Out of the 13,800 different genes spotted on microarrays, very few genes (<0.5%) appeared to be induced more than 2-fold or repressed more than 2.5-fold in both cell lines.",

keywords = "HL60, Irradiation, Jurkat, Raji, X rays",

author = "M. Mori and Benotmane, {M. A.} and J. Verheyde and {Van Hummelen}, P. and Hooghe-Peters, {E. L.} and C. Desaintes",

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AU - Mori, M.

AU - Benotmane, M. A.

AU - Verheyde, J.

AU - Van Hummelen, P.

AU - Hooghe-Peters, E. L.

AU - Desaintes, C.

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AB - The response to X-ray irradiation of three different human hematopoietic cell lines originating from T (Jurkat), B (Raji), and promyelocytic (HL60) leukemia was analyzed. The survival after irradiation differed among the three cell lines, with Jurkat cells being the most vulnerable and HL60 being the least sensitive. The profile of gene expression was studied with the microarray technique in both Jurkat and HL60 cell lines. Out of the 13,800 different genes spotted on microarrays, very few genes (<0.5%) appeared to be induced more than 2-fold or repressed more than 2.5-fold in both cell lines.

KW - HL60

KW - Irradiation

KW - Jurkat

KW - Raji

KW - X rays

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/axs_1147052

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