Gold nanoparticles coated with antibodies lead to ROSdependent apoptotic cell death in non-cancerous human cell lines

Ornella Fichera; Karen Van Hoecke; Sarah Baatout; Thomas Cardinaels; Carine Michiels; Stéphane Lucas; An Aerts

doi:10.1007/s00259-018-4148-3

Gold nanoparticles coated with antibodies lead to ROSdependent apoptotic cell death in non-cancerous human cell lines

Ornella Fichera, Karen Van Hoecke, Sarah Baatout, Thomas Cardinaels, Carine Michiels, Stéphane Lucas, An Aerts

Research output › peer-review

Abstract

In cancer radiotherapy, gold nanoparticles (AuNPs) have emerged as promising radiosensitizers increasing the effectiveness of external beam radiotherapy by local production of reactive oxygen species (ROS) and secondary electrons upon irradiation. At UNamur, 5 nm gold nanoparticles coated with an organic shell of polyallylamine are produced by plasma vapor deposition (AuNPs@PPAA). Optionally, the AuNPs@PPAA can be conjugated to anti-EGFR antibodies (Cetuximab) (AuNPs@PPAACtxb) which actively target EGFR-overexpressing cancer cells in vitro and in vivo.

Original language	English
Title of host publication	Annual Congress of the European Association of Nuclear Medicine October 13 – 17, 2018 Düsseldorf, Germany
Pages	S653
Number of pages	1
Volume	45
DOIs	https://doi.org/10.1007/s00259-018-4148-3
State	Published - 31 Dec 2018
Event	2018 - Annual congress of the European association of Nuclear medicine - Dusseldorf Duration: 13 Oct 2018 → 17 Oct 2018

Publication series

Name	European Journal of Nuclear Medicine and Molecular Imaging
Publisher	Springer
ISSN (Print)	1619-7070

Conference

Conference	2018 - Annual congress of the European association of Nuclear medicine
Country/Territory	Germany
City	Dusseldorf
Period	2018-10-13 → 2018-10-17

Access to Document

10.1007/s00259-018-4148-3License: Unspecified

Cite this

Fichera, O., Van Hoecke, K., Baatout, S., Cardinaels, T., Michiels, C., Lucas, S., & Aerts, A. (2018). Gold nanoparticles coated with antibodies lead to ROSdependent apoptotic cell death in non-cancerous human cell lines. In Annual Congress of the European Association of Nuclear Medicine October 13 – 17, 2018 Düsseldorf, Germany (Vol. 45, pp. S653). (European Journal of Nuclear Medicine and Molecular Imaging). https://doi.org/10.1007/s00259-018-4148-3

Fichera, Ornella ; Van Hoecke, Karen ; Baatout, Sarah et al. / Gold nanoparticles coated with antibodies lead to ROSdependent apoptotic cell death in non-cancerous human cell lines. Annual Congress of the European Association of Nuclear Medicine October 13 – 17, 2018 Düsseldorf, Germany. Vol. 45 2018. pp. S653 (European Journal of Nuclear Medicine and Molecular Imaging).

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title = "Gold nanoparticles coated with antibodies lead to ROSdependent apoptotic cell death in non-cancerous human cell lines",

abstract = "In cancer radiotherapy, gold nanoparticles (AuNPs) have emerged as promising radiosensitizers increasing the effectiveness of external beam radiotherapy by local production of reactive oxygen species (ROS) and secondary electrons upon irradiation. At UNamur, 5 nm gold nanoparticles coated with an organic shell of polyallylamine are produced by plasma vapor deposition (AuNPs@PPAA). Optionally, the AuNPs@PPAA can be conjugated to anti-EGFR antibodies (Cetuximab) (AuNPs@PPAACtxb) which actively target EGFR-overexpressing cancer cells in vitro and in vivo.",

keywords = "Nanoparticles, Cancer Radiotherapy, Anti-bodies, In-vivo",

author = "Ornella Fichera and {Van Hoecke}, Karen and Sarah Baatout and Thomas Cardinaels and Carine Michiels and St{\'e}phane Lucas and An Aerts",

note = "Score=3; 2018 - Annual congress of the European association of Nuclear medicine ; Conference date: 13-10-2018 Through 17-10-2018",

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Fichera, O, Van Hoecke, K , Baatout, S , Cardinaels, T, Michiels, C, Lucas, S & Aerts, A 2018, Gold nanoparticles coated with antibodies lead to ROSdependent apoptotic cell death in non-cancerous human cell lines. in Annual Congress of the European Association of Nuclear Medicine October 13 – 17, 2018 Düsseldorf, Germany. vol. 45, European Journal of Nuclear Medicine and Molecular Imaging, pp. S653, 2018 - Annual congress of the European association of Nuclear medicine, Dusseldorf, Germany, 2018-10-13. https://doi.org/10.1007/s00259-018-4148-3

Gold nanoparticles coated with antibodies lead to ROSdependent apoptotic cell death in non-cancerous human cell lines. / Fichera, Ornella; Van Hoecke, Karen ; Baatout, Sarah et al.
Annual Congress of the European Association of Nuclear Medicine October 13 – 17, 2018 Düsseldorf, Germany. Vol. 45 2018. p. S653 (European Journal of Nuclear Medicine and Molecular Imaging).

Research output › peer-review

TY - GEN

T1 - Gold nanoparticles coated with antibodies lead to ROSdependent apoptotic cell death in non-cancerous human cell lines

AU - Fichera, Ornella

AU - Van Hoecke, Karen

AU - Baatout, Sarah

AU - Cardinaels, Thomas

AU - Michiels, Carine

AU - Lucas, Stéphane

AU - Aerts, An

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Y1 - 2018/12/31

N2 - In cancer radiotherapy, gold nanoparticles (AuNPs) have emerged as promising radiosensitizers increasing the effectiveness of external beam radiotherapy by local production of reactive oxygen species (ROS) and secondary electrons upon irradiation. At UNamur, 5 nm gold nanoparticles coated with an organic shell of polyallylamine are produced by plasma vapor deposition (AuNPs@PPAA). Optionally, the AuNPs@PPAA can be conjugated to anti-EGFR antibodies (Cetuximab) (AuNPs@PPAACtxb) which actively target EGFR-overexpressing cancer cells in vitro and in vivo.

AB - In cancer radiotherapy, gold nanoparticles (AuNPs) have emerged as promising radiosensitizers increasing the effectiveness of external beam radiotherapy by local production of reactive oxygen species (ROS) and secondary electrons upon irradiation. At UNamur, 5 nm gold nanoparticles coated with an organic shell of polyallylamine are produced by plasma vapor deposition (AuNPs@PPAA). Optionally, the AuNPs@PPAA can be conjugated to anti-EGFR antibodies (Cetuximab) (AuNPs@PPAACtxb) which actively target EGFR-overexpressing cancer cells in vitro and in vivo.

KW - Nanoparticles

KW - Cancer Radiotherapy

KW - Anti-bodies

KW - In-vivo

UR - https://ecm.sckcen.be/OTCS/llisapi.dll/open/38089737

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DO - 10.1007/s00259-018-4148-3

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VL - 45

T3 - European Journal of Nuclear Medicine and Molecular Imaging

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BT - Annual Congress of the European Association of Nuclear Medicine October 13 – 17, 2018 Düsseldorf, Germany

T2 - 2018 - Annual congress of the European association of Nuclear medicine

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ER -

Fichera O, Van Hoecke K , Baatout S , Cardinaels T, Michiels C, Lucas S et al. Gold nanoparticles coated with antibodies lead to ROSdependent apoptotic cell death in non-cancerous human cell lines. In Annual Congress of the European Association of Nuclear Medicine October 13 – 17, 2018 Düsseldorf, Germany. Vol. 45. 2018. p. S653. (European Journal of Nuclear Medicine and Molecular Imaging). doi: 10.1007/s00259-018-4148-3