Gold nanoparticles coated with antibodies lead to ROSdependent apoptotic cell death in non-cancerous human cell lines

Ornella Fichera, Karen Van Hoecke, Sarah Baatout, Thomas Cardinaels, Carine Michiels, Stéphane Lucas, An Aerts

    Research outputpeer-review

    Abstract

    In cancer radiotherapy, gold nanoparticles (AuNPs) have emerged as promising radiosensitizers increasing the effectiveness of external beam radiotherapy by local production of reactive oxygen species (ROS) and secondary electrons upon irradiation. At UNamur, 5 nm gold nanoparticles coated with an organic shell of polyallylamine are produced by plasma vapor deposition (AuNPs@PPAA). Optionally, the AuNPs@PPAA can be conjugated to anti-EGFR antibodies (Cetuximab) (AuNPs@PPAACtxb) which actively target EGFR-overexpressing cancer cells in vitro and in vivo.
    Original languageEnglish
    Title of host publicationAnnual Congress of the European Association of Nuclear Medicine October 13 – 17, 2018 Düsseldorf, Germany
    PagesS653
    Number of pages1
    Volume45
    DOIs
    StatePublished - 31 Dec 2018
    Event2018 - Annual congress of the European association of Nuclear medicine - Dusseldorf
    Duration: 13 Oct 201817 Oct 2018

    Publication series

    NameEuropean Journal of Nuclear Medicine and Molecular Imaging
    PublisherSpringer
    ISSN (Print)1619-7070

    Conference

    Conference2018 - Annual congress of the European association of Nuclear medicine
    Country/TerritoryGermany
    CityDusseldorf
    Period2018-10-132018-10-17

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