TY - JOUR
T1 - Gold nanoparticles meet medical radionuclides
AU - Daems, Noami
AU - Michiels, Carine
AU - Lucas, Stéphane
AU - Baatout, Sarah
AU - Aerts, An
N1 - Score=10
PY - 2021/9/1
Y1 - 2021/9/1
N2 - Thanks to their unique optical and physicochemical properties, gold nanoparticles have gained increased interest as radiosensitizing, photothermal therapy and optical imaging agents to enhance the effectiveness of cancer detection and therapy. Furthermore, their ability to carry multiple medically relevant radionuclides broadens their use to nuclear medicine SPECT and PET imaging as well as targeted radionuclide therapy. In this review, we discuss the radiolabeling process of gold nanoparticles and their use in (multimodal) nuclear medicine imaging to better understand their specific distribution, uptake and retention in different in vivo cancer models. In addition, radiolabeled gold nanoparticles enable image-guided therapy is reviewed aswell as the enhancement of targeted radionuclide therapy and nanobrachytherapy through an increased dose deposition and radiosensitization, as demonstrated by multiple Monte Carlo studies and experimental in vitro and in vivo studies.
AB - Thanks to their unique optical and physicochemical properties, gold nanoparticles have gained increased interest as radiosensitizing, photothermal therapy and optical imaging agents to enhance the effectiveness of cancer detection and therapy. Furthermore, their ability to carry multiple medically relevant radionuclides broadens their use to nuclear medicine SPECT and PET imaging as well as targeted radionuclide therapy. In this review, we discuss the radiolabeling process of gold nanoparticles and their use in (multimodal) nuclear medicine imaging to better understand their specific distribution, uptake and retention in different in vivo cancer models. In addition, radiolabeled gold nanoparticles enable image-guided therapy is reviewed aswell as the enhancement of targeted radionuclide therapy and nanobrachytherapy through an increased dose deposition and radiosensitization, as demonstrated by multiple Monte Carlo studies and experimental in vitro and in vivo studies.
KW - Radiosensitization
KW - Dose enhancement
KW - Targeted radionuclide therapy
KW - Cancer theranostics
KW - Nuclear medicine
KW - Nanobrachytherapy
UR - https://ecm.sckcen.be/OTCS/llisapi.dll?func=ll&objId=44881622&objAction=download&viewType=1
U2 - 10.1016/j.nucmedbio.2021.06.001
DO - 10.1016/j.nucmedbio.2021.06.001
M3 - Article
SN - 0969-8051
VL - 100-101
SP - 61
EP - 90
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
ER -