Under normal culture conditions endothelial cells (ECs) grow as single layers on the bottom surface of cell culture flasks. In numerous experiments using simulated microgravity we noticed that the ECs formed three-dimensional, tube-like cell aggregates resembling the intima of small, rudimentary blood vessels. The SPHEROIDS project has now shown that similar processes occur in space. For the first time, we could observe scaffold-free growth of human ECs into multicellular spheroids and tubular structures during an experiment in real microgravity. With further investigation of the space samples we hope to understand endothelial 3D growth and to improve the in vitro engineering of biocompatible vessels which could be used in surgery.
|Title of host publication
|69th International astronautical congres - IAC 2018
|Curran Associates, Inc.
|Number of pages
|Published - Apr 2019
|AIC 2018 - 69th International astronautical congres - Bremen
Duration: 1 Oct 2018 → 5 Oct 2018
|AIC 2018 - 69th International astronautical congres
|2018-10-01 → 2018-10-05