Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project)

Isabelle Thierry-Chef; Beate Timmermann; Neige Journy; Marie-Odile Bernier; Richard McNally; Jérémie Dabin; Lorenzo Brualla; Siamak Haghdoost; Adelaida Sarukhan; Karin Haustermans; Inge De Wit; Sofie Isebaert; Yasmin Lassen-Ramshad; Louise Tram Henriksen; Morten Hoyer; Laura Toussaint; Guillaume Boissonnat; Juliette Thariat; Charlotte Demoor-Goldschmidt; Nadia Haddy; Stéphanie Bolle; Brice Fresneau; Amel Belhout; Steffen Dreger; Hajo Zeeb; Maria Grazia Andreassi; Jonica Campolo; Andreas Jahnen; Cecile Ronckers; John H. Maduro; Kristina Kjaerheim; Gaute Dohlen; Trude Eid Robsahm; Hilde Olerud; Utheya Salini Thevathas; Susmita Afroz; Bjorn Helge Osteras; Uwe Schneider; Linda Walsh; Agnés Dumas; Angéla Jackson; Estelle Rage; Marijke De Saint-Hubert; Richard Hardy; Christian Bäumer; Theresa Steinmeier; Suzan Botzenhardt; Martina Wette; Rodney Ortiz; Vadim Chumak

doi:10.1051/epjn/2023009

Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project)

Isabelle Thierry-Chef, Beate Timmermann, Neige Journy, Marie-Odile Bernier, Richard McNally, Jérémie Dabin, Lorenzo Brualla, Siamak Haghdoost, Adelaida Sarukhan, Karin Haustermans, Inge De Wit, Sofie Isebaert, Yasmin Lassen-Ramshad, Louise Tram Henriksen, Morten Hoyer, Laura Toussaint, Guillaume Boissonnat, Juliette Thariat, Charlotte Demoor-Goldschmidt, Nadia HaddyStéphanie Bolle, Brice Fresneau, Amel Belhout, Steffen Dreger, Hajo Zeeb, Maria Grazia Andreassi, Jonica Campolo, Andreas Jahnen, Cecile Ronckers, John H. Maduro, Kristina Kjaerheim, Gaute Dohlen, Trude Eid Robsahm, Hilde Olerud, Utheya Salini Thevathas, Susmita Afroz, Bjorn Helge Osteras, Uwe Schneider, Linda Walsh, Agnés Dumas, Angéla Jackson, Estelle Rage, Marijke De Saint-Hubert, Richard Hardy, Christian Bäumer, Theresa Steinmeier, Suzan Botzenhardt, Martina Wette, Rodney Ortiz, Vadim Chumak

Research output › peer-review

Abstract

The use of ionising radiation (IR) for medical diagnosis and treatment procedures has had a major impact on the survival of paediatric patients. Although the benefits of these techniques lead to efficient health care, evaluation of potential associated long-term health effects is required. HARMONIC aims to better understand the increased risk of cancer and non-cancer effects after exposure to medical IR in children with cancer treated with modern external beam radiotherapy (EBRT) – radiation energy in MeV range – and in children with cardiac defects diagnosed and treated with cardiac fluoroscopy procedures (CFP) – radiation energy in keV range. The project investigates, among survivors of paediatric cancer, potential endocrine dysfunction, cardiovascular and neurovascular damage, health-related quality of life and second (and subsequent) primary cancer (SPC). The cardiac component builds a pooled cohort of approximately 90 000 paediatric patients who underwent CFP during childhood and adolescence to investigate cancer risk following exposure to IR and explore the potential effects of conditions predisposing to cancer. HARMONIC develops software tools to allow dose reconstruction in both EBRT and CFP to enable epidemiological investigations and future optimisation of treatments. With the creation of a biobank of blood and saliva samples, HARMONIC aims to provide a mechanistic understanding of radiation-induced adverse health effects and identify potential biomarkers that can predict these effects.

Original language	English
Article number	22
Number of pages	12
Journal	EPJ Nuclear Sciences and Technologies
Volume	9
DOIs	https://doi.org/10.1051/epjn/2023009
State	Published - 2023

ASJC Scopus subject areas

Nuclear and High Energy Physics
Energy Engineering and Power Technology
Electrical and Electronic Engineering
Nuclear Energy and Engineering

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Thierry-Chef, I., Timmermann, B., Journy, N., Bernier, M.-O., McNally, R., Dabin, J., Brualla, L., Haghdoost, S., Sarukhan, A., Haustermans, K., De Wit, I., Isebaert, S., Lassen-Ramshad, Y., Tram Henriksen, L., Hoyer, M., Toussaint, L., Boissonnat, G., Thariat, J., Demoor-Goldschmidt, C., ... Chumak, V. (2023). Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project). EPJ Nuclear Sciences and Technologies, 9, Article 22. https://doi.org/10.1051/epjn/2023009

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title = "Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project)",

abstract = "The use of ionising radiation (IR) for medical diagnosis and treatment procedures has had a major impact on the survival of paediatric patients. Although the benefits of these techniques lead to efficient health care, evaluation of potential associated long-term health effects is required. HARMONIC aims to better understand the increased risk of cancer and non-cancer effects after exposure to medical IR in children with cancer treated with modern external beam radiotherapy (EBRT) – radiation energy in MeV range – and in children with cardiac defects diagnosed and treated with cardiac fluoroscopy procedures (CFP) – radiation energy in keV range. The project investigates, among survivors of paediatric cancer, potential endocrine dysfunction, cardiovascular and neurovascular damage, health-related quality of life and second (and subsequent) primary cancer (SPC). The cardiac component builds a pooled cohort of approximately 90 000 paediatric patients who underwent CFP during childhood and adolescence to investigate cancer risk following exposure to IR and explore the potential effects of conditions predisposing to cancer. HARMONIC develops software tools to allow dose reconstruction in both EBRT and CFP to enable epidemiological investigations and future optimisation of treatments. With the creation of a biobank of blood and saliva samples, HARMONIC aims to provide a mechanistic understanding of radiation-induced adverse health effects and identify potential biomarkers that can predict these effects.",

keywords = "HARMONIC, Ionising radiation, Cancer, Health effects, Paediatrics, Radiotherapy",

author = "Isabelle Thierry-Chef and Beate Timmermann and Neige Journy and Marie-Odile Bernier and Richard McNally and J{\'e}r{\'e}mie Dabin and Lorenzo Brualla and Siamak Haghdoost and Adelaida Sarukhan and Karin Haustermans and {De Wit}, Inge and Sofie Isebaert and Yasmin Lassen-Ramshad and {Tram Henriksen}, Louise and Morten Hoyer and Laura Toussaint and Guillaume Boissonnat and Juliette Thariat and Charlotte Demoor-Goldschmidt and Nadia Haddy and St{\'e}phanie Bolle and Brice Fresneau and Amel Belhout and Steffen Dreger and Hajo Zeeb and Andreassi, {Maria Grazia} and Jonica Campolo and Andreas Jahnen and Cecile Ronckers and Maduro, {John H.} and Kristina Kjaerheim and Gaute Dohlen and Robsahm, {Trude Eid} and Hilde Olerud and Thevathas, {Utheya Salini} and Susmita Afroz and Osteras, {Bjorn Helge} and Uwe Schneider and Linda Walsh and Agn{\'e}s Dumas and Ang{\'e}la Jackson and Estelle Rage and {De Saint-Hubert}, Marijke and Richard Hardy and Christian B{\"a}umer and Theresa Steinmeier and Suzan Botzenhardt and Martina Wette and Rodney Ortiz and Vadim Chumak",

note = "Score=10 Funding Information: The HARMONIC project has received funding from the Euratom research and training programme 2014-2018 under grant agreement No. 847707. Funding Information: The HARMONIC project has received funding from the Euratom research and training programme 2014–2018 under grant agreement No. 847707. Publisher Copyright: {\textcopyright} 2023 EDP Sciences. All rights reserved.",

year = "2023",

doi = "10.1051/epjn/2023009",

language = "English",

volume = "9",

journal = "EPJ Nuclear Sciences and Technologies",

issn = "2491-9292",

publisher = "EDP Sciences",

}

Thierry-Chef, I, Timmermann, B, Journy, N, Bernier, M-O, McNally, R, Dabin, J, Brualla, L, Haghdoost, S, Sarukhan, A, Haustermans, K, De Wit, I, Isebaert, S, Lassen-Ramshad, Y, Tram Henriksen, L, Hoyer, M, Toussaint, L, Boissonnat, G, Thariat, J, Demoor-Goldschmidt, C, Haddy, N, Bolle, S, Fresneau, B, Belhout, A, Dreger, S, Zeeb, H, Andreassi, MG, Campolo, J, Jahnen, A, Ronckers, C, Maduro, JH, Kjaerheim, K, Dohlen, G, Robsahm, TE, Olerud, H, Thevathas, US, Afroz, S, Osteras, BH, Schneider, U, Walsh, L, Dumas, A, Jackson, A, Rage, E, De Saint-Hubert, M, Hardy, R, Bäumer, C, Steinmeier, T, Botzenhardt, S, Wette, M, Ortiz, R & Chumak, V 2023, 'Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project)', EPJ Nuclear Sciences and Technologies, vol. 9, 22. https://doi.org/10.1051/epjn/2023009

TY - JOUR

T1 - Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project)

AU - Thierry-Chef, Isabelle

AU - Timmermann, Beate

AU - Journy, Neige

AU - Bernier, Marie-Odile

AU - McNally, Richard

AU - Dabin, Jérémie

AU - Brualla, Lorenzo

AU - Haghdoost, Siamak

AU - Sarukhan, Adelaida

AU - Haustermans, Karin

AU - De Wit, Inge

AU - Isebaert, Sofie

AU - Lassen-Ramshad, Yasmin

AU - Tram Henriksen, Louise

AU - Hoyer, Morten

AU - Toussaint, Laura

AU - Boissonnat, Guillaume

AU - Thariat, Juliette

AU - Demoor-Goldschmidt, Charlotte

AU - Haddy, Nadia

AU - Bolle, Stéphanie

AU - Fresneau, Brice

AU - Belhout, Amel

AU - Dreger, Steffen

AU - Zeeb, Hajo

AU - Andreassi, Maria Grazia

AU - Campolo, Jonica

AU - Jahnen, Andreas

AU - Ronckers, Cecile

AU - Maduro, John H.

AU - Kjaerheim, Kristina

AU - Dohlen, Gaute

AU - Robsahm, Trude Eid

AU - Olerud, Hilde

AU - Thevathas, Utheya Salini

AU - Afroz, Susmita

AU - Osteras, Bjorn Helge

AU - Schneider, Uwe

AU - Walsh, Linda

AU - Dumas, Agnés

AU - Jackson, Angéla

AU - Rage, Estelle

AU - De Saint-Hubert, Marijke

AU - Hardy, Richard

AU - Bäumer, Christian

AU - Steinmeier, Theresa

AU - Botzenhardt, Suzan

AU - Wette, Martina

AU - Ortiz, Rodney

AU - Chumak, Vadim

N1 - Score=10 Funding Information: The HARMONIC project has received funding from the Euratom research and training programme 2014-2018 under grant agreement No. 847707. Funding Information: The HARMONIC project has received funding from the Euratom research and training programme 2014–2018 under grant agreement No. 847707. Publisher Copyright: © 2023 EDP Sciences. All rights reserved.

PY - 2023

Y1 - 2023

N2 - The use of ionising radiation (IR) for medical diagnosis and treatment procedures has had a major impact on the survival of paediatric patients. Although the benefits of these techniques lead to efficient health care, evaluation of potential associated long-term health effects is required. HARMONIC aims to better understand the increased risk of cancer and non-cancer effects after exposure to medical IR in children with cancer treated with modern external beam radiotherapy (EBRT) – radiation energy in MeV range – and in children with cardiac defects diagnosed and treated with cardiac fluoroscopy procedures (CFP) – radiation energy in keV range. The project investigates, among survivors of paediatric cancer, potential endocrine dysfunction, cardiovascular and neurovascular damage, health-related quality of life and second (and subsequent) primary cancer (SPC). The cardiac component builds a pooled cohort of approximately 90 000 paediatric patients who underwent CFP during childhood and adolescence to investigate cancer risk following exposure to IR and explore the potential effects of conditions predisposing to cancer. HARMONIC develops software tools to allow dose reconstruction in both EBRT and CFP to enable epidemiological investigations and future optimisation of treatments. With the creation of a biobank of blood and saliva samples, HARMONIC aims to provide a mechanistic understanding of radiation-induced adverse health effects and identify potential biomarkers that can predict these effects.

AB - The use of ionising radiation (IR) for medical diagnosis and treatment procedures has had a major impact on the survival of paediatric patients. Although the benefits of these techniques lead to efficient health care, evaluation of potential associated long-term health effects is required. HARMONIC aims to better understand the increased risk of cancer and non-cancer effects after exposure to medical IR in children with cancer treated with modern external beam radiotherapy (EBRT) – radiation energy in MeV range – and in children with cardiac defects diagnosed and treated with cardiac fluoroscopy procedures (CFP) – radiation energy in keV range. The project investigates, among survivors of paediatric cancer, potential endocrine dysfunction, cardiovascular and neurovascular damage, health-related quality of life and second (and subsequent) primary cancer (SPC). The cardiac component builds a pooled cohort of approximately 90 000 paediatric patients who underwent CFP during childhood and adolescence to investigate cancer risk following exposure to IR and explore the potential effects of conditions predisposing to cancer. HARMONIC develops software tools to allow dose reconstruction in both EBRT and CFP to enable epidemiological investigations and future optimisation of treatments. With the creation of a biobank of blood and saliva samples, HARMONIC aims to provide a mechanistic understanding of radiation-induced adverse health effects and identify potential biomarkers that can predict these effects.

KW - HARMONIC

KW - Ionising radiation

KW - Cancer

KW - Health effects

KW - Paediatrics

KW - Radiotherapy

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U2 - 10.1051/epjn/2023009

DO - 10.1051/epjn/2023009

M3 - Article

SN - 2491-9292

VL - 9

JO - EPJ Nuclear Sciences and Technologies

JF - EPJ Nuclear Sciences and Technologies

M1 - 22

ER -