Abstract
The labilization in the bond between histones and DNA (Hagen 1962) is thought to result in a leakage of histones into the cytoplasm, where they could affect cellular metabolism and thus contribute to interphase death of lymphoid cells (Whitfield, Brohee and Youdale 1964, Whitfield and Youdale 1966). In support of this hypothesis, changes in the histone-DNA ratio observed by Ernst
(1961, 1962) (Ernst and Hagen 1960) in irradiated lymphoid organs are often adduced. Even in rat liver, these authors observed a loss of more than 80 per cent of the histones 14 hours after 1000 R whole-body irradiation. Techniques of isolation and characterization of histones have advanced considerably since these experiments were carried out, and it seemed of interest to verify the earlier results.
(1961, 1962) (Ernst and Hagen 1960) in irradiated lymphoid organs are often adduced. Even in rat liver, these authors observed a loss of more than 80 per cent of the histones 14 hours after 1000 R whole-body irradiation. Techniques of isolation and characterization of histones have advanced considerably since these experiments were carried out, and it seemed of interest to verify the earlier results.
| Original language | English |
|---|---|
| Pages (from-to) | 389-392 |
| Number of pages | 4 |
| Journal | International Journal of Radiation Biology |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1969 |
| Externally published | Yes |
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Radiology Nuclear Medicine and imaging