Homologous and heterologous regulation of the helodermin/vasoactive‐intestinal‐peptide response in the murine radiation leukemia‐virus‐induced lymphoma cell line BL/VL3

J. Abello; C. Damien; P. Robberecht; Robert Hooghe; André Vandermeers; Marie-Claire  Vandermeers-Piret; J. Christophe

doi:10.1111/j.1432-1033.1989.tb14923.x

Homologous and heterologous regulation of the helodermin/vasoactive‐intestinal‐peptide response in the murine radiation leukemia‐virus‐induced lymphoma cell line BL/VL3

J. Abello, C. Damien, P. Robberecht, Robert Hooghe, André Vandermeers, Marie-Claire Vandermeers-Piret, J. Christophe

Research output › peer-review

Abstract

1 Functional vasoactive intestinal peptide (VIP)/helodermin receptors and β2‐adrenoceptors coexist in membranes from a cultured cloned BL/VL3 cell line of murine T‐cell lymphoma induced by a radiation leukemia virus (see preceding paper in this journal).

2 Short‐term (5–30 min) exposures of BL/VL3 cells to VIP or isoproterenol induced both homologous and heterologous desensitization. The potency of VIP and isoproterenol to desensitize was similar to their potency to occupy receptors and activate adenylate cyclase.

3 Long‐term (16‐h) exposure of BL/VL3 cells to VIP induced homologous down regulation only, whereas isoproterenol induced both homologous and heterologous down regulation. The potency of VIP, peptide histidine isoleucinamide, helodermin, helospectin, and [D‐Phe2]VIP on the one hand, and of isoproterenol on the other hand, to decrease homologous responses was comparable to their potency for receptor occupancy and adenylate cyclase activation.

Original language	English
Pages (from-to)	269-274
Number of pages	6
Journal	European Journal of Biochemistry
Volume	183
Issue number	2
DOIs	https://doi.org/10.1111/j.1432-1033.1989.tb14923.x
State	Published - 1 Aug 1989

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Abello, J., Damien, C., Robberecht, P., Hooghe, R., Vandermeers, A., Vandermeers-Piret, M.-C., & Christophe, J. (1989). Homologous and heterologous regulation of the helodermin/vasoactive‐intestinal‐peptide response in the murine radiation leukemia‐virus‐induced lymphoma cell line BL/VL3. European Journal of Biochemistry, 183(2), 269-274. https://doi.org/10.1111/j.1432-1033.1989.tb14923.x

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title = "Homologous and heterologous regulation of the helodermin/vasoactive‐intestinal‐peptide response in the murine radiation leukemia‐virus‐induced lymphoma cell line BL/VL3",

abstract = "1 Functional vasoactive intestinal peptide (VIP)/helodermin receptors and β2‐adrenoceptors coexist in membranes from a cultured cloned BL/VL3 cell line of murine T‐cell lymphoma induced by a radiation leukemia virus (see preceding paper in this journal). 2 Short‐term (5–30 min) exposures of BL/VL3 cells to VIP or isoproterenol induced both homologous and heterologous desensitization. The potency of VIP and isoproterenol to desensitize was similar to their potency to occupy receptors and activate adenylate cyclase. 3 Long‐term (16‐h) exposure of BL/VL3 cells to VIP induced homologous down regulation only, whereas isoproterenol induced both homologous and heterologous down regulation. The potency of VIP, peptide histidine isoleucinamide, helodermin, helospectin, and [D‐Phe2]VIP on the one hand, and of isoproterenol on the other hand, to decrease homologous responses was comparable to their potency for receptor occupancy and adenylate cyclase activation. ",

keywords = "vasoactive‐intestinal‐peptide, Homologous and heterologous regulation, BL/VL3, leukemia‐virus‐induced ",

author = "J. Abello and C. Damien and P. Robberecht and Robert Hooghe and Andr{\'e} Vandermeers and Marie-Claire Vandermeers-Piret and J. Christophe",

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Abello, J, Damien, C, Robberecht, P, Hooghe, R, Vandermeers, A, Vandermeers-Piret, M-C & Christophe, J 1989, 'Homologous and heterologous regulation of the helodermin/vasoactive‐intestinal‐peptide response in the murine radiation leukemia‐virus‐induced lymphoma cell line BL/VL3', European Journal of Biochemistry, vol. 183, no. 2, pp. 269-274. https://doi.org/10.1111/j.1432-1033.1989.tb14923.x

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AU - Hooghe, Robert

AU - Vandermeers, André

AU - Vandermeers-Piret, Marie-Claire

AU - Christophe, J.

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N2 - 1 Functional vasoactive intestinal peptide (VIP)/helodermin receptors and β2‐adrenoceptors coexist in membranes from a cultured cloned BL/VL3 cell line of murine T‐cell lymphoma induced by a radiation leukemia virus (see preceding paper in this journal). 2 Short‐term (5–30 min) exposures of BL/VL3 cells to VIP or isoproterenol induced both homologous and heterologous desensitization. The potency of VIP and isoproterenol to desensitize was similar to their potency to occupy receptors and activate adenylate cyclase. 3 Long‐term (16‐h) exposure of BL/VL3 cells to VIP induced homologous down regulation only, whereas isoproterenol induced both homologous and heterologous down regulation. The potency of VIP, peptide histidine isoleucinamide, helodermin, helospectin, and [D‐Phe2]VIP on the one hand, and of isoproterenol on the other hand, to decrease homologous responses was comparable to their potency for receptor occupancy and adenylate cyclase activation.

AB - 1 Functional vasoactive intestinal peptide (VIP)/helodermin receptors and β2‐adrenoceptors coexist in membranes from a cultured cloned BL/VL3 cell line of murine T‐cell lymphoma induced by a radiation leukemia virus (see preceding paper in this journal). 2 Short‐term (5–30 min) exposures of BL/VL3 cells to VIP or isoproterenol induced both homologous and heterologous desensitization. The potency of VIP and isoproterenol to desensitize was similar to their potency to occupy receptors and activate adenylate cyclase. 3 Long‐term (16‐h) exposure of BL/VL3 cells to VIP induced homologous down regulation only, whereas isoproterenol induced both homologous and heterologous down regulation. The potency of VIP, peptide histidine isoleucinamide, helodermin, helospectin, and [D‐Phe2]VIP on the one hand, and of isoproterenol on the other hand, to decrease homologous responses was comparable to their potency for receptor occupancy and adenylate cyclase activation.

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