How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Trent Davis, Kevin Tabury, Shouan Zhu, Nathaniel J. Szewczyk, Monica Monici, Christiane Hahn, Jason Hatton, Angelique Van Ombergen, Christopher Puhl

Research outputpeer-review

Abstract

Progress in mechanobiology allowed us to better understand the important role of mechanical forces in the regulation of biological processes. Space research in the field of life sciences clearly showed that gravity plays a crucial role in biological processes. The space environment offers the unique opportunity to carry out experiments without gravity, helping us not only to understand the effects of gravitational alterations on biological systems but also the mechanisms underlying mechanoperception and cell/tissue response to mechanical and gravitational stresses. Despite the progress made so far, for future space exploration programs it is necessary to increase our knowledge on the mechanotransduction processes as well as on the molecular mechanisms underlying microgravity-induced cell and tissue alterations. This white paper reports the suggestions and recommendations of the SciSpacE Science Community for the elaboration of the section of the European Space Agency roadmap “Biology in Space and Analogue Environments” focusing on “How are cells and tissues influenced by gravity and what are the gravity perception mechanisms?” The knowledge gaps that prevent the Science Community from fully answering this question and the activities proposed to fill them are discussed.
Original languageEnglish
Article number16
Number of pages7
Journalnpj Microgravity
Volume10
Issue number1
DOIs
StatePublished - Dec 2024

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Agricultural and Biological Sciences (miscellaneous)
  • Medicine (miscellaneous)
  • Space and Planetary Science
  • Materials Science (miscellaneous)
  • Physics and Astronomy (miscellaneous)

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