Abstract
Megakaryocytes are platelet forming cells and are characterized by polyploidization, a phenomenon by which nuclear division occurs without corresponding cytoplasmic separation. Among the markers allowing to identify megakaryocytes, glycoprotein (GP) IIIa with GPIb and GPIIb are the most important. Using GPIIIa as a marker to recognize megakaryocytes in the bone marrow we have estimated GPIIIa expression by flow cytometry in megakaryocyte populations from normal individuals and from patients with chronic myelogenous leukemia, immune thrombocytopenic purpura or polycythemia vera. We showed that the expression of GPIIIa is decreasing during megakaryocyte polyploidization in normal and pathological situations.
| Original language | English |
|---|---|
| Pages (from-to) | 5187-5189 |
| Number of pages | 3 |
| Journal | Anticancer research |
| Volume | 19 |
| Issue number | 6 B |
| State | Published - Nov 1999 |
ASJC Scopus subject areas
- Oncology
- Cancer Research