In vivo studies in male mice on the mutagenic effects of inorganic arsenic

G. H. Deknudt; A. Léonard; J. Arany; G. Jenar Du Buisson; E. Delavignette

doi:10.1093/mutage/1.1.33

In vivo studies in male mice on the mutagenic effects of inorganic arsenic

G. H. Deknudt, A. Léonard, J. Arany, G. Jenar Du Buisson, E. Delavignette

Research output › peer-review

Abstract

The ability of sodium meta-arsenite (NaAsO₂) to produce genetic damage in vivo has been evaluated in mice by the micronucleus test on bone marrow cells and the dominant lethality and sperm abnormality assays on male germ cells. The doserelated linear increase of micronuclei observed in somatic cells together with the negative results obtained in reproductive cells suggest that NaAsO₂, under the conditions of the present experiments, displays clastogenic properties in vivo in laboratory animals, but is unable to produce heritable damage.

Original language	English
Pages (from-to)	33-39
Number of pages	7
Journal	Mutagenesis
Volume	1
Issue number	1
DOIs	https://doi.org/10.1093/mutage/1.1.33
State	Published - Jan 1986

Funding

We are grateful to Mr G.Decat for the statistical analysis. This work was supported by research contract Euratom-SCK No. B1O-D-378-81-B.

Funders	Funder number
Not added	N01-CO-65341

ASJC Scopus subject areas

General Medicine

Access to Document

10.1093/mutage/1.1.33

Cite this

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