Induction of neuronal apoptosis after prenatal irradiation in mice: an in vivo study

Lander Thyssen; Mieke Verslegers; Rafi Benotmane; Sarah Baatout

Induction of neuronal apoptosis after prenatal irradiation in mice: an in vivo study

Lander Thyssen, Mieke Verslegers, Rafi Benotmane, Sarah Baatout

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Abstract

This study aimed to provide insight into early radiation-induced brain anomalies that might be related to previously observed cognitive and behavioural malfunctions in mice prenatally irradiated with moderate to high doses of X-radiation. More specifically, a disturbance of developental processes was investigated by means of immunohistochemical techniques in prenatally irradiated mouse embryos at the onset of neurogenesis (embryonic days 11 and 15).

Original language	English
Awarding Institution	KU Leuven
Supervisors/Advisors	Arckens, Lutgarde, Supervisor, External person
Place of Publication	Mol, Belgium
Publisher	KUL - Katholieke Universiteit Leuven
State	Published - 30 Jan 2015

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Induction of neuronal apoptosis after prenatal irradiation in mice - an in vivo studyFinal published version, 2.81 MBLicense: Unspecified

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AU - Baatout, Sarah

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AB - This study aimed to provide insight into early radiation-induced brain anomalies that might be related to previously observed cognitive and behavioural malfunctions in mice prenatally irradiated with moderate to high doses of X-radiation. More specifically, a disturbance of developental processes was investigated by means of immunohistochemical techniques in prenatally irradiated mouse embryos at the onset of neurogenesis (embryonic days 11 and 15).

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KW - prenatal X-radiation

KW - apoptosis

KW - proliferation

KW - mouse

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M3 - Master's thesis

PB - KUL - Katholieke Universiteit Leuven

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