Abstract
Dose-effect curves of chromosomal aberrations can be modified after irradiation by selection, presence of a non-uniform cell population and/or repair. In order to affect not only the scale but also the shape of dose curves, these factors must depend on radiation dose. Selection either by interphase death, early elimination of severe abnormalities or delayed elimination of small genetic detriments can result in modifying a square law curve into a pseudolinear one or into one showing saturation at high doses. If the irradiated population is not uniform, conditions are conceivable under which aberrations are retained for a long time and then disappear rapidly. Repair, if dose dependent, can only result in a dose-effect curve following a law with a higher dose exponent than that induced by the exposure.
| Original language | English |
|---|---|
| Pages (from-to) | 175-182 |
| Number of pages | 8 |
| Journal | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis |
| Volume | 12 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1971 |
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Health, Toxicology and Mutagenesis