Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans: joint RENEB and EURADOS inter-laboratory comparisons

Ellina Macaeva, Roel Quintens, Olivier Van Hoey, Elizabeth Ainsbury, Christophe Badie, Stephen Barnard, Grainne Manning, Jayne Moquet, Michael Abend, Celine Bassinet, Emanuela Bortolin, Lily Bossin, Clare Bricknell, Kamil Brzoska, Zina Cemusova, Maria Christiansson, Guillaume Cosler, Sara Della Monaca, François Desangles, Michael DischerSven Doucha-Senf, Jon Eakins, Paola Fattibene, Eric Gregoire, Kamile Guogyte, Ralf Kriehuber, Jungil Lee, David Lloyd, Fiona Lyng, Matthaeus Majewski, Stephen W.S. McKeever, Aidan Meade, Radhia M'kacher, Dinesh Medipally, Ursula Oestreicher, Dominik Oskamp, Jerome Pateux, Matthias Port, Maria Cristina Quattrini, Michelle Ricoul, Laurence Roy, Laure Sabatier, Sergey Sholom, Sonja Strunz, François Trompier, Marco Valente, Ivan Veronese, Andrzej Wojcik, Clemens Woda

Research outputpeer-review


Purpose: RENEB, ‘Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,’ is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There is a requirement to test and/or validate these candidate techniques and inter-comparison exercises are a well-established method for such validation. Materials and methods: The authors present details of inter-comparisons of four such new methods: dicentric chromosome analysis including telomere and centromere staining; the gene expression assay carried out in whole blood; Raman spectroscopy on blood lymphocytes, and detection of radiationinduced thermoluminescent signals in glass screens taken from mobile phones. Results: In general the results show good agreement between the laboratories and methods within the expected levels of uncertainty, and thus demonstrate that there is a lot of potential for each of the candidate techniques. Conclusions: Further work is required before the new methods can be included within the suite of reliable dosimetry methods for use by RENEB partners and others in routine and emergency response scenarios.
Original languageEnglish
Pages (from-to)99-109
Number of pages12
JournalInternational Journal of Radiation Biology
Issue number1
StatePublished - Jan 2017

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