Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit

Damian M. Bailey; Dieter Blottner; Hanns-Christian Gunga; Stefan Schneider; Virginia E. Wotring; Sarah Baatout; Marco Durante; Rik H. Olde Engberink; Nandu Goswami; Martina Heer; Anna-Maria Liphardt; Monica Monici; Francesco Pagnini; Claudia Stern; Jan-Bernd Stukenborg; Tobias Weber; Laurence Vico; Olivier White; Angelique Van Ombergen; Alexander Choukèr

doi:10.1038/s41526-025-00537-1

Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit

Damian M. Bailey
, Dieter Blottner
, Hanns-Christian Gunga
, Stefan Schneider
, Virginia E. Wotring
, Sarah Baatout
, Marco Durante
, Rik H. Olde Engberink
, Nandu Goswami
, Martina Heer
, Anna-Maria Liphardt
, Monica Monici
, Francesco Pagnini
, Claudia Stern
, Jan-Bernd Stukenborg
, Tobias Weber
, Laurence Vico
, Olivier White
, Angelique Van Ombergen
, Alexander Choukèr

Research output › peer-review

Abstract

Human spaceflight is advancing toward sustainable exploration through initiatives like NASA’s Artemis program, aiming for a lunar outpost and eventual Mars mission. Astronauts face hazards including altered gravity, isolation, and cosmic radiation, linked to over thirty health risks. This review, reflecting ESA community expertise, outlines how understanding the space exposome–integrome interaction can improve risk stratification, guide personalized countermeasures, and address knowledge gaps essential for safe deep-space exploration.

Original language	English
Article number	82
Number of pages	11
Journal	npj Microgravity
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41526-025-00537-1
State	Published - Dec 2025

ASJC Scopus subject areas

Medicine (miscellaneous)
Materials Science (miscellaneous)
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Agricultural and Biological Sciences (miscellaneous)
Physics and Astronomy (miscellaneous)
Space and Planetary Science

Access to Document

10.1038/s41526-025-00537-1License:

Cite this

Bailey, D. M., Blottner, D., Gunga, H.-C., Schneider, S., Wotring, V. E., Baatout, S., Durante, M., Olde Engberink, R. H., Goswami, N., Heer, M., Liphardt, A.-M., Monici, M., Pagnini, F., Stern, C., Stukenborg, J.-B., Weber, T., Vico, L., White, O., Van Ombergen, A., & Choukèr, A. (2025). Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit. npj Microgravity, 11(1), Article 82. https://doi.org/10.1038/s41526-025-00537-1

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abstract = "Human spaceflight is advancing toward sustainable exploration through initiatives like NASA{\textquoteright}s Artemis program, aiming for a lunar outpost and eventual Mars mission. Astronauts face hazards including altered gravity, isolation, and cosmic radiation, linked to over thirty health risks. This review, reflecting ESA community expertise, outlines how understanding the space exposome–integrome interaction can improve risk stratification, guide personalized countermeasures, and address knowledge gaps essential for safe deep-space exploration.",

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author = "Bailey, \{Damian M.\} and Dieter Blottner and Hanns-Christian Gunga and Stefan Schneider and Wotring, \{Virginia E.\} and Sarah Baatout and Marco Durante and \{Olde Engberink\}, \{Rik H.\} and Nandu Goswami and Martina Heer and Anna-Maria Liphardt and Monica Monici and Francesco Pagnini and Claudia Stern and Jan-Bernd Stukenborg and Tobias Weber and Laurence Vico and Olivier White and \{Van Ombergen\}, Angelique and Alexander Chouk{\`e}r",

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year = "2025",

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doi = "10.1038/s41526-025-00537-1",

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Bailey, DM, Blottner, D, Gunga, H-C, Schneider, S, Wotring, VE, Baatout, S, Durante, M, Olde Engberink, RH, Goswami, N, Heer, M, Liphardt, A-M, Monici, M, Pagnini, F, Stern, C, Stukenborg, J-B, Weber, T, Vico, L, White, O, Van Ombergen, A & Choukèr, A 2025, 'Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit', npj Microgravity, vol. 11, no. 1, 82. https://doi.org/10.1038/s41526-025-00537-1

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AU - Schneider, Stefan

AU - Wotring, Virginia E.

AU - Baatout, Sarah

AU - Durante, Marco

AU - Olde Engberink, Rik H.

AU - Goswami, Nandu

AU - Heer, Martina

AU - Liphardt, Anna-Maria

AU - Monici, Monica

AU - Pagnini, Francesco

AU - Stern, Claudia

AU - Stukenborg, Jan-Bernd

AU - Weber, Tobias

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KW - Deep-space exploration

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KW - Health risks in space

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