Investigating in situ natural genetic transformation of Acinetobacter sp. BD413 in biofilms with confocal laser scanning microscopy

Larissa Hendrickx, Stefan Wuertz

    Research outputpeer-review

    Abstract

    In situ monitoring tools are the method of choice to investigate natural genetic transformation of Acinetobacter sp. BD413 in biofilms. The combination of genes encoding for the green fluorescent protein (gfp) or its derivatives as transforming DNA and confocal laser scanning microscopy (CLSM) as an analysis tool can provide for a convenient experimental set-up. The tasks that are necessary to perform an in situ natural genetic transformation study are: construction of the tools for in vivo labeling of transconjugants; control experiments to reduce false positive/negative signals; and design of the mathematical formulae to describe the natural transformation events inside the biofilm.
    Original languageEnglish
    Title of host publicationGenetic Engineering
    Subtitle of host publicationPrinciples and Methods
    PublisherKluwer Academic Publishers
    Pages159-173
    Number of pages15
    Volume26
    DOIs
    StatePublished - 2004

    Publication series

    NameGenetic engineering
    ISSN (Print)0196-3716

    ASJC Scopus subject areas

    • General Medicine

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