Investigation of chemical impurities in formulations, phytotherapics and polyvitaminic medicines by k0-instrumental neutron activation analysis

A. Leal; M.A. Menezes; Peter Vermaercke; Liesel Sneyers; CEM Jensen; Michel Bruggeman

doi:10.1016/j.nima.2006.04.010

Investigation of chemical impurities in formulations, phytotherapics and polyvitaminic medicines by k0-instrumental neutron activation analysis

A. Leal, M.A. Menezes, Peter Vermaercke, Liesel Sneyers, CEM Jensen, Michel Bruggeman

Research output › peer-review

Abstract

In this work, comparative k0-Instrumental Neutron-Activation Analysis was performed by CDTN/CNEN/Brazil and SCK.CEN/ Belgium in order to investigate the elemental concentration in samples of the same industrialised and manipulated medicine, a phytotherapic and a polyvitaminic, commonly commercialised in Brazil. The preliminary results from both Institutes are in very good agreement. Any serious contamination with possible risks to human health were found in the medicines compared with the expected values. In the case of polyvitaminic, some impurities, unexpected elements, such as La, Ti and Sm, were found in very low concentration. This first assessment confirmed the effectiveness of the k0-method in analysing such matrices. r 2006 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	729-732
Journal	Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume	564
Issue number	2
DOIs	https://doi.org/10.1016/j.nima.2006.04.010
State	Published - Jun 2006

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Leal, A., Menezes, M. A., Vermaercke, P., Sneyers, L., Jensen, CEM., & Bruggeman, M. (2006). Investigation of chemical impurities in formulations, phytotherapics and polyvitaminic medicines by k0-instrumental neutron activation analysis. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 564(2), 729-732. https://doi.org/10.1016/j.nima.2006.04.010

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abstract = "In this work, comparative k0-Instrumental Neutron-Activation Analysis was performed by CDTN/CNEN/Brazil and SCK.CEN/ Belgium in order to investigate the elemental concentration in samples of the same industrialised and manipulated medicine, a phytotherapic and a polyvitaminic, commonly commercialised in Brazil. The preliminary results from both Institutes are in very good agreement. Any serious contamination with possible risks to human health were found in the medicines compared with the expected values. In the case of polyvitaminic, some impurities, unexpected elements, such as La, Ti and Sm, were found in very low concentration. This first assessment confirmed the effectiveness of the k0-method in analysing such matrices. r 2006 Elsevier B.V. All rights reserved.",

keywords = "Neutron activation analysis, k0-standardisation, Phytotherapic, Manipulated medicines, Natural medicines",

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Leal, A, Menezes, MA, Vermaercke, P , Sneyers, L, Jensen, CEM & Bruggeman, M 2006, 'Investigation of chemical impurities in formulations, phytotherapics and polyvitaminic medicines by k0-instrumental neutron activation analysis', Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 564, no. 2, pp. 729-732. https://doi.org/10.1016/j.nima.2006.04.010

Investigation of chemical impurities in formulations, phytotherapics and polyvitaminic medicines by k0-instrumental neutron activation analysis. / Leal, A.; Menezes, M.A.; Vermaercke, Peter et al.
In: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 564, No. 2, 06.2006, p. 729-732.

Research output › peer-review

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AU - Leal, A.

AU - Menezes, M.A.

AU - Vermaercke, Peter

AU - Sneyers, Liesel

AU - Jensen, CEM

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AB - In this work, comparative k0-Instrumental Neutron-Activation Analysis was performed by CDTN/CNEN/Brazil and SCK.CEN/ Belgium in order to investigate the elemental concentration in samples of the same industrialised and manipulated medicine, a phytotherapic and a polyvitaminic, commonly commercialised in Brazil. The preliminary results from both Institutes are in very good agreement. Any serious contamination with possible risks to human health were found in the medicines compared with the expected values. In the case of polyvitaminic, some impurities, unexpected elements, such as La, Ti and Sm, were found in very low concentration. This first assessment confirmed the effectiveness of the k0-method in analysing such matrices. r 2006 Elsevier B.V. All rights reserved.

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KW - k0-standardisation

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KW - Manipulated medicines

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Leal A, Menezes MA, Vermaercke P , Sneyers L, Jensen CEM, Bruggeman M. Investigation of chemical impurities in formulations, phytotherapics and polyvitaminic medicines by k0-instrumental neutron activation analysis. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2006 Jun;564(2):729-732. doi: 10.1016/j.nima.2006.04.010